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Fellowship Program Director: Dr. Paru Patrawalla, an accomplished teacher and widely invited lecturer with an extensive background in using Medical Simulation Training techniques as well as a national expert in the growing field of Critical Care Ultrasonography.

Associate Program Director/MSM Site Director: Dr. Mirna Mohanraj, a passionate educator committed to novel education techniques, innovative curriculum design and trainee well-being.

Assistant Program Director: Dr. Lauren Blackwell, a dedicated clinician-educator interested in curricular development, interdisciplinary communication and education.

Core Faculty: The combined core faculty in the Divisions of Pulmonary, Critical Care and Sleep Medicine at MSM, MSW and MSBI include more than two dozen full-time, internationally recognized faculty members who possess a broad array of clinical and research interests covering the major aspects of pulmonary, critical care and sleep medicine. Fellows interact with core faculty on a daily basis through bedside rounds, daily clinical conferences, journal clubs, didactic sessions and research projects.

The development of new targets that inhibit bacterial survival is critical to the discovery of new antimicrobial drugs. Numerous pathways have been targeted including cell wall synthesis, protein synthesis, nucleic acid synthesis, and general metabolism. However, the development of new antibiotic classes has been slow, and despite the identification of new antimicrobial targets, no new classes of compounds have been identified since 1987 [1]. Antimicrobial resistance (AMR) is an on-going complication in the use of antimicrobials, reducing the effectiveness of current treatments, and further exacerbating the need for the development of new drugs and targets. AMR represents a heavy burden on both, life, and the economy with an estimation of 10 million deaths per year by 2050 [2]. Additionally, with pharmaceutical companies changing their focus from antimicrobial drug discovery, there is an urgent need to find novel compounds to treat infections [3,4]. Some of these compounds could be effective as combination therapies, or adjuvants.

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Despite the positive aspects of ATBC, its poor solubility in water makes it difficult to estimate real concentrations and impairs experimental reproducibility. Especially problematic are longer incubations or treatments at high compound concentrations. Furthermore, poor solubility can impair the bioavailability, the administration route and even cause toxicity. This is a major problem encountered in drug discovery that can be tackled by medicinal chemists in multiple ways [36,37]. An example is the addition of polar groups to Tioconazole, a poorly soluble antifungal agent used for skin infection, to create Fluconazole, an antifungal with improved solubility that facilitates systemic use [38]. Finally, we also determined that ATBC is a TolC substrate, therefore, clinical strains will most likely have a diminished sensitivity to the compound [39].

A 79 year-old asymptomatic female was referred to our center after being discovered a 3 cm left axillary lymph node detected during a routine screening mammogram. Except from the enlarged left axillary lymphadenopathy, the remaining physical exam was within normal limits. An ultrasound-guided fine needle biopsy revealed histologic features consistent with Hodgkin's lymphoma, nodular sclerosing type. Immunostains confirmed the presence of Reed Sternberg cells that were positive for CD 30, focally positive for CD 15, and negative for CD 20 and EMA. Bilateral bone marrow showed no evidence of HL involvement. A positron-emission tomography detected abnormal uptake in multiple enlarged lymph nodes above and below the diaphragm, and in the thoracic spine, at T9, T11 and T12 vertebral body levels. The patient was successfully treated with doxorubicin-based combination chemotherapy regimen.

Early in her career, Kelly Turner, PhD, a researcher, lecturer, and counselor in Integrative Oncology, was shocked to discover that no one was studying episodes of radical remission, when people recover against all odds without the help of conventional medicine, or after conventional medicine has failed. She was so fascinated by this kind of remission that she spent eight years travelling through 10 countries to learn what factors that people experiencing this phenomenon encountered.

Forget everything you think you know about your body and food and discover the new science of how the body heals itself. Learn how to identify the strategies and the dosages for using food to transform your resilience and health in Eat to Beat Disease. Eat to Beat Disease isn't about what foods to avoid, but rather is a life-changing guide to the hundreds of healing foods to add to your meals that support the body's defense systems

In Cured, Dr. Rediger digs down to the root causes of illness, showing how to create an environment that sets the stage for healing. He reveals the patterns behind healing and lays out the physical and mental principles associated with recovery: first, we need to physically heal our diet and our immune systems. Next, we need to mentally heal our stress response and our identities. Through rigorous research, Dr. Rediger shows that much of our physical reality is created in our minds. Our perception changes our experience, even to the point of changing our physical bodies.

Mr. Madon has held a number of senior roles across the organization including head of Brookfield's Corporate Lending business. Prior to joining Brookfield in 1998, Mr. Madon worked at PricewaterhouseCoopers in corporate finance and recovery.

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