Publications

(*, corresponding author; # contribute equally; underlined authors are from the Guo lab)

2024

1.      Song Y, Zhao Z, Xu L, Huang P, Gao J, Li J, Wang X, Zhou Y, Wang J, Zhao W, Wang L, Zheng C, Gao B, Jiang L, Liu K, Guo Y, Yao X, Duan L. Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum. Dev Cell. 2024 Apr 1:S1534-5807(24)00180-1.

2.      Bu Y, Wang J, Ni S, Lu Z, Guo Y, Yobas L. High-Performance Gel-Free and Label-Free Size Fractionation of Extracellular Vesicles with Two-Dimensional Electrophoresis in a Microfluidic Artificial Sieve.  Anal Chem. 2024 Feb 27;96(8):3508-3516.

2023

3.  Li T#, Yang F#, Heng Y, Zhou S, Wang G, Wang J, Wang J, Chen X, Yao ZP*, Wu Z* and Guo Y*. TMED10 mediates the trafficking of insulin like growth factor 2 along the secretory pathway for myoblast differentiation. Proc Natl Acad Sci U S A. 2023. 120(46): e2215285120.

4.  Chen R, Tang X, Zhao Y, Shen Z, Zhang M, Shen Y, Li T, Zhang L, Wang J, Cui B, Fei P, Guo Y*, Du S*, Yao S*. Deep-Learning Super-1 Resolution Microscopy Reveals Nanometer-Scale Intracellular Dynamics at the Millisecond Temporal Resolution. Nature Communications. 2023 May 18;14(1):2854.

5.  Bu Y, Wang J, Ni S, Guo Y and Yobas L. Continuous-flow label-free size fractionation of extracellular vesicles through electrothermal fluid rolls and dielectrophoresis synergistically integrated in a microfluidic device. Lab on a Chip. 2023 Mar 23.

6.  Wang J, Lau PK, Li CW, Yusong Guo*. The clathrin adaptor complex-1 and Rab12 regulate post-Golgi trafficking of wild-type EGFR. Journal of Biological Chemistry. 2023 Feb 4;299(3):102979.

7.  Li B, Zeng Y, Lo WS, Guo Y, Jiang L. In vitro reconstitution of COPII vesicles from Arabidopsis thaliana suspension cultured cells. Nature Protocol. 2023 Jan 4.

8.  Wang M.#, Wang J.#, Guo Y*. Reconstituting vesicle budding from the trans Golgi network and immunoisolation of vesicles enriched with a specific cargo client. Methods in Molecular Biology. 2023; 2557:289-302.

2022

9.  Mesias VSD, Zhu H, Tang X, Dai X, Liu W, Guo Y, Huang J. Moderate Binding between Two SARS-CoV-2 Protein Segments and α-Synuclein Alters Its Toxic Oligomerization Propensity Differently. J Phys Chem Lett. 2022 Nov 17;13(45):10642-10648.

10.  Tang X, Wang T, Guo Y*. Export of polybasic motif-containing secretory proteins BMP8A and SFRP1 from the endoplasmic reticulum is regulated by surfeit locus protein 4 (SURF4). Journal of Biological Chemistry. 2022 Dec;298(12):102687.

11.  Tang X., Chen R.,  Mesias V.S.D., Wang T., Wang Y., Poljak K., Fan X., Miao H., Hu J., Zhang L., Huang J., Yao S., Miller E.A., Guo Y*. 2022. A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged-variant of sonic hedgehog. Proc Natl Acad Sci U S A. 119(11):e2113991119.

12.  Li T and Guo Y*. ADP-ribosylation factor family of small GTP-binding proteins: their membrane recruitment, activation, crosstalk and functions. 2022. Front Cell Dev Biol. Feb 3;10:813353.

2021

13.  Huang Y., Yin H., Li B., Wu Q., Liu Y., Poljak K., Maldutyte J., Tang X., Wang M., Wu Z., Miller E.A., Jiang L., Yao Z. *,  and Guo Y*. 2021. An in vitro vesicle formation assay reveals novel cargo clients and factors that mediate vesicular trafficking. Proc Natl Acad Sci U S A. 118(35):e2101287118.

14.  Li B, Zeng Y, Cao W, Zhang W, Cheng L, Yin H, Wu Q, Wang X, Huang Y, Lau WC, Yao Z, Guo Y*, Jiang L*. (2021) A Distinct Giant COPII Vesicle Population in Arabidopsis thaliana. Nature Plant. 7(10):1335-1346.

15.  Mesias VSD, Zhu H, Tang X, Dai X, Guo Y, Liu W, Huang J. Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering. Chem Commun (Camb). 2021 Jul 15;57(57):6979-6982.

16.  Feng D, Wang J, Yang W, Li J, Lin X, Zha F, Wang X, Ma L, Choi NT, Mii Y, Takada S, Huen MSY, Guo Y, Zhang L, Gao B. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation. Sci Adv. 2021 May 14;7(20):eabg2099.

17.  Sun S, Tang X, Guo Y.*, Hu, J*. ER composition and form: proteins in and out. Current Opinion in Cell Biology. 2021. Feb 18;71:1-6.

2020

18.  Yang F, Li T, Peng Z, Liu Y, and Guo Y*. The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations. Journal of Biological Chemistry 2020. 295(49):16643-16654.

19.  Tang X, Zhang L, Ma T, Wang M, Li B, Jiang L, Yan Y, Guo Y*. Molecular mechanisms that regulate export of the planar cell-polarity protein Frizzled-6 out of the endoplasmic reticulum. Journal of Biological Chemistry. Journal of Biological Chemistry. 2020. 295, 8972-8987.

20.  Tang X#, Yang F#, Guo Y*. Cell-free Reconstitution of the Packaging of Cargo Proteins into Vesicles at the trans Golgi Network. Bio-protocol. 2020. 10(5): e3537.

21.  Yang Z, Yang Y, Wang M, Wang T, Fok HKF, Jiang B, Xiao W, Kou S, Guo Y, Yan Y, Deng X, Zhang WB, Sun F*. (2020). Dynamically tunable, macroscopic molecular networks enabled by cellular synthesis of 4-arm star-like proteins. Matter 2, 233-249.

2019

22.  Huang Y#, Ma T#, Lau PK#, Wang J, Zhao T, Du S, Loy MMT, Guo Y*. Visualization of protein sorting at the trans-Golgi network and endosomes through super-resolution imaging. Front Cell Dev Biol. 2019. Sep 3;7:181.

23.  Niu L#, Ma T#, Yang F, Yan B, Tang X, Yin H, Wu Q, Huang Y, Yao ZP, Wang J, Guo Y*, Hu J*. Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2019. 116:14029-14038. 

24.  Mao Y#, Tu R#, Huang Y#, Mao D, Yang Z, Lau PK, Wang J, Ni J*, Guo Y*, Xie T*. The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking. Development. 2019. 146. 

2018

25.  Huang Y#, Ma T#, Guo Y*. Intracellular trafficking of planar cell polarity proteins. Frontier in Biology. 2018. 13(6): 395-405.

26.  Ma T, Li B, Wang R, Lau PK, Huang Y, Jiang L, Schekman R, Guo Y*. A mechanism for differential sorting of planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi Network. Journal of Biological Chemistry. 2018. Jun 1; 293(22): 8410-8427.  

2017

27.  Guo Y*, Yang F, Tang X. An Overview of Protein Secretion in Yeast and Animal Cells. Methods Mol Biol. 2017.1662:1-17.

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Prior to joining HKUST

1.        Guo Y, Sirkis DW, Schekman R. Protein Sorting at the trans-Golgi Network. Annu Rev Cell Dev Biol. 2014 Aug 18.

2.        Guo Y, Zanetti G, Schekman R. A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network. eLife. 2013; 2:e00160. (highlighted in Nature Cell Biology and in the Annual Review of Cell and Developmental Biology)

3.        Guo Y and Linstedt AD. Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat. Cellular Logistics 2013 Dec; 3:1, e27609.

4.        Gong H, Guo Y, Linstedt AD and Schwartz R. Discrete, continuous and stochastic models of protein sorting in the Golgi. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jan; 81(1 Pt 1):011914.

5.        Srinivasa G, Fickus MC, Guo Y, Linstedt AD and Kovačević J. Active mask segmentation of fluorescence images. IEEE Transactions on Image Processing. 2009 Aug; 18(8):1817-1829.

6.        Guo Y, Punj V, Sengupta D and Linstedt AD. Coat-tether interaction in Golgi organization. Molecular Biology of the Cell. 2008 July; 19(7):2830-43. (highlighted in Incytes from MBC)

7.        Srinivasa G, Fickus M, Gonzales-Rivero MN, Hsieh SY, Guo Y, Linstedt AD and Kovačević J. Active mask segmentation for the cell-volume computation and Golgi-body segmentation of HeLa cell images. Proc. IEEE Intl. Symp. Biomed. Imaging, Paris, France, 2008 May; pp. 348-351.

8.        Guo Y and Linstedt AD. COPII-Golgi protein interactions regulate COPII coat assembly and Golgi size. Journal of Cell Biology. 2006 July; 174(1): 53-63. (highlighted in Faculty of 1000 and in the Annual Review of Cell and Developmental Biology)

9.        Guo Y, Kong L, Wang Y, Huang Z. Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-houpu decoction. Phytotherapy Research. 2004 March;18(3): 204-207.

10.    Kong L, Yang C, Ge F, Wang H, Guo Y. A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice. Journal of Ethnopharmacology. 2004 Aug; 93(2-3): 325-330.

11.    Wang H, Ge F, Guo Y, Kong L. Effects of aqueous extract in herba of Lysimachiachristinae on hyperuricemia in mice. ZhongguoZhong Yao ZaZhi. 2002; 27(12): 939-41, 944.