Transgressing blood-brain barrier via functionalized nano aggregates
Overcoming physiological barriers, particularly the blood-brain barrier (BBB), continues to be the most significant difficulty in the treatment and prognosis of neurological illnesses, despite the technological advances in medicine and drug delivery. Out of >7000 drugs available on the Comprehensive Medicinal Chemistry (CMC) database, <6% can treat any CNS-related disease. We aim to improve the statistics of BBB permeation by employing novel synthesized nano aggregates from bioinspired precursors for facilitated receptor-mediated endocytosis of the drug carrier and adopting stealth strategies to evade barrier exclusion. Our research is focused on but not limited to the development of stimuli-responsive vehicles for drug transport, bio-imaging fluoroprobes, and tumour-targeting across the BBB.
Hydrogel-based Wastewater Bioremediation via enzyme immobilization
Addressing this pressing global challenge of industrial wastewater treatment especially in urban areas, demands innovative and sustainable solutions. We emphasize the development and implementation of integrated enzyme immobilization, to tackle two major environmental concerns: water contamination and solid waste. Key components of the research include the synthesis and characterization of metal-centered hydrogel composites using nanoparticle-embedded porous hydrogels with enhanced compressive strength combined with enzyme immobilization, subsequently integrated with solid-waste-derived functionalized grapheneoxide nanosheets, for optimum chemical decontamination of industrial wastewater.