Our laboratory, which is part of the Department of Biotechnology at the University of Verona, studies how eukaryotic cells receive, process, and transmit signals from the extracellular environment and how the integration of multiple signals results in a specific biological output. In the cell, such signaling networks are spatiotemporally controlled by post-translational modifications. We are particularly interested in the role of ubiquitylation, a versatile post-translational modification that controls all crucial biological processes either by targeting proteins for proteasomal degradation or by triggering a multitude of regulatory signaling events. To that end, we utilize a variety of biochemical, molecular and cell biological approaches including proteomics, live imaging and organoid technology along with genetic tools such as CRISPR genome editing and RNA interference.