The number of cards dealt per player depends on how many people are playing.
Use this guide:
*For two player see “OPTIONAL 2 PLAYER DECK” below
optional In-Depth Explainer and Gameplay
optional rapid game mechanics overview
🎮 Gameplay
Shuffle the play deck.
Deal cards to each player (see table for hand size).
Flip a Bonus Card:
Round 1: Flip one at random.
Later Rounds: The player with the lowest score draws two Bonus Cards, chooses one, and places it face-up. The chosen card applies to all players for that round.
Each player chooses one card from their hand and places it face-up.
All players reveal their cards at the same time.
Pass the rest of your hand to the left.
Repeat Steps 4–5 until no cards remain in hand.
When hands are empty, the round ends.
Begin a new round (shuffle, deal, flip Bonus Card) and continue.
The game ends when you can no longer deal a full hand to each player.
The last full hand dealt is the final round.
If you’d like to play a quick extra round with leftover cards:
2 players: 4 cards each
4, 6, or 8 players: 2 cards each
3, 5, or 7 players: 1 card each
🧮 Scoring
Score your points after each round and add your Bonus Card points.
Each card has a point value in the top-right corner and sometimes special modifiers in the bottom-right corner.
🔄 Rounds
Each round continues until all the cards in the players’ hands are played.
The game ends when there aren’t enough cards left to deal a full hand to every player.
🏆 Scoring Sets, and Bonuses
• ✅ Bonus: Only applies to cards played that round.
• 🏆 Scoring Sets: Points cap at the card max shown in the scoring set. If there are points for 1x, 2x, and 3x, but not 4x, a 4th card does not add more points. If it says >4x it does add points (e.g. Destroying Angels).
• 🏆Scoring Sets Within Rounds: If a card has bonuses for 1x and 2x, and both cards are laid in the same round. The first mushroom counts as 1x, and the 2nd as 2x. They do not both count as 2x.
• 🧺 Emetic Race: First to hit 12 oz wins, and it is counted on the turn (not round) that the card is laid. If there is a tie the points are split.
• 🌈 Psilocybin: Counted only at the end of the game. Double point modifier cannot be used on "emetic race". Ties = full points to all (both +10 if multiple have highest, and -5 if multiple have lowest).
• 🍲 Potluck: If played with charcoal, charcoal resolves first.
• 💊 Modifiers(Antidotes): Do not stack, no extra points for duplicate modifiers.
🎲 Optional Rule Variations
Spice things up! Try one of these alternate rule sets or make your own! Better yet, play 3 games, scoring different each game — highest score wins!
Bonus cards apply to your entire field, not just mushrooms played this turn. (a great way to learn the shrooms!)
Modifiers must be played before the mushroom they work on (extra strategy!)
Modifiers can stack for bigger effects.
Consider drawing 2 cards from your first dealt hand each round
👥 OPTIONAL 2 PLAYER DECK
For a simpler two-player experience, play 5 rounds of 6 cards each. Here’s how to trim the deck to 69 cards:
• Remove either The Yellow Knight or Brown Roll-Rim (#4)
• Remove #4 Psilocybin
• Remove #4 Amatoxin containing mushrooms (but keep Destroying Angels and Death Cap!)
• Remove #8 Emetic mushrooms (total of 12 oz)
Bell-Shaped Noalanea (#2) ,Yellow Unicorn (#2), The Sickener (#2), and Tiger Tricholoma (#2)
For a deep dive into poisons, gameplay tips, and the story behind GOTTA PICCEM, scan the QR code on your deck’s materials—or visit
👉 www.ThePoisonLab.com
A full break down of the different toxins, how they score in the game, and how many are in the deck is available here.