My Research Work

Reproductive system is Important system in our body, It is important role play in save the species on earth. Reproductive system regulate by the Hormones, Hormones are chemicals released from various types of glands. Reproductive system regulate by the hypothalamic–pituitary–gonad axis. Hypothalamus it is a part of brain. It is higher center in our body. It is the chairman man of the endocrine society. which influenced by limbic system in our body. limbic system are involved in our behavioral and emotional responses like happiness, depression, stress, fear, tired and so on. That means reproductive system indirectly affected by environmentally change like Plastic Pollution, Routine change other types of pollutions.

Gordhan’s research interest is aimed at understanding the gonadotropins and metabolic activity mechanisms involved in PCOS, Diabetes using molecular and cellular biology techniques and animal model systems. PCOS is endocrine disruptive disease. It is characterized by Many abnormalities in PCOS Patients like Reproductive abnormalities, Endocrine abnormalities, Metabolism abnormalities and Psychological abnormalities in PCOS women. PCOS Infertility incidence risk is enormously high in all over the world and increasing in developing countries like India. It is the fact that almost 3-25% of PCOS patients infertile mainly due to its immature follicles development. No specific drugs are available in prevention of PCOS infertility and PCOS metabolism abnormalities. PCOS patients are actually prescribed for symptoms of PCOS, No drugs approved by FAD/CDSCO for the treatment of PCOS. Some drugs are Clomiphene citrate (Non steroidal) it is similar to estrogen and help in stimulation of ovulation. Aromatase inhibitors and ovulation inducible like letrozole, anastrozole and androgen inhibitor Flutamide. Cyproterone etc. GnRH antagonist like Leuprolide acetate and Nafarelin acetate and for insulin resistance used metformin and D-Chiro-inositol. Risk of PCOS incidence has been also linked with different types of diseases including diabetes, hypercholesterolemia and obesity. Therefore, there is an urgent need for improved understanding of the molecular biology of these diseases and development of more selective and targeted Gene, Hormonal therapeutics and Epigenetic drugs. 

Another research on Tuberculosis (TB), Tuberculosis is a chronic infectious disease caused by M. tuberculosis, an obligate intracellular, gram positive bacterium that primarily targets alveolar macrophages in the lungs. Upon infection, M.tb establishes a persistent state within host cells, evading immune clearance without inducing immediate clinical symptoms. Over time, infected macrophages undergo cellular senescence, a condition associated with latent tuberculosis (latent TB).

Gordhan's research aims to elucidate the molecular pathways governing cellular senescence during M.tb infection. His work seeks to uncover how M.tb manipulates host cell signaling to maintain this dormant state and to identify potential molecular targets that could be leveraged to prevent or disrupt latent TB, thereby reducing the risk of reactivation. His findings contribute to a deeper understanding of TB pathogenesis and may aid in the development of novel therapeutic strategies.