Laboratory of 3D Genome Organisation
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About us
About us
Our group is interested in studying 3D genome organization and 3D genome pathologies. We are passionate about exploring the three-dimensional organization of the genome across eukaryotic species. Comparative analysis of 3D genome architecture among diverse organisms offers valuable insights into the principles governing genome structure and its functional implications. Disruptions in 3D genome architecture are increasingly recognized as contributors to developmental disorders and human disease. To address these challenges, we employ an interdisciplinary approach integrating Next Generation Genomics, Genome Editing, Epidemiology, Biochemistry, Mass spectrometry, high resolution Imaging and Computational methods to uncover the underlying perturbed molecular ecosystems in 3D genome pathologies.
Our group is interested in studying 3D genome organization and 3D genome pathologies. We are passionate about exploring the three-dimensional organization of the genome across eukaryotic species. Comparative analysis of 3D genome architecture among diverse organisms offers valuable insights into the principles governing genome structure and its functional implications. Disruptions in 3D genome architecture are increasingly recognized as contributors to developmental disorders and human disease. To address these challenges, we employ an interdisciplinary approach integrating Next Generation Genomics, Genome Editing, Epidemiology, Biochemistry, Mass spectrometry, high resolution Imaging and Computational methods to uncover the underlying perturbed molecular ecosystems in 3D genome pathologies.
How DNA, about 2 m in length is pacaked in a micron sized cell nucleus?
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Funding
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