Publications

2026

• An, H*, Oh, J*, Bae, J. Advances in IL-2 Family Cytokine-Based Cancer Therapies: Overcoming Challenges Through Molecular Engineering and Delivery Strategies. Immune Network. 2026 Feb;26(1):e6.  *co–first authors

• Choi SP, Yang J, Park IB, Kang SJ, Park SW, Lee CH, Lee HJ, Bae J, Choi CY, Shin J, Kim JI, Jin HY, Lee YS, Chun T. Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Transl Res. 2026 Mar;289:27-39. 

• Park SW, Choi CY, Park IB, Kang SJ, Lee HJ, Kim JI, Bae J, Geum D, Cheon YP, Chun T. LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcription. Redox Biol. 2026 Apr;91:104070. 

• Son SR, Cho SY, Bae J, Yeon GB, Lee HS, Hwang H, Kwon Y, Rhee H, Kwon HC, Kim WK, Jang DS, Kwon J. Astragalus membranaceus sprouts and their unique constituents regulate reactive oxygen species production, inflammation-related senescence-associated secretory phenotype components, and extracellular matrix in fibroblasts. Food Res Int. 2026 Mar 31;228:118390. 

• Seo Y, Pak J, Han J, Bae J, Hwang SS. Viral transduction for T cell engineering in immunotherapy. Mol Cells. 2026 Feb;49(2):100311. 

2025

• Yoon, J. H.*, Yeon, G. B.*, Lee, H., An, H., Oh, J., Kang, S. J., Park, I. B., Lim, S. A., Hwang, S. S., Kim, D. S., Kim, J. H., Chun, T., Fu, Y. X., & Bae, J. (2025). Tumor-targeted delivery of CXCL10 by mesenchymal stromal cells potentiates adoptive T cell therapy to treat solid tumors. Biomedecine & pharmacotherapie, 192, 118579. *co–first authors

• Lim, S., Kum, S., Choi, J. O., Bae, J., & Hwang, S. S. (2025). Approaches to murine T cell isolation and activation. Molecules and cells, 48(12), 100286.

• Guo, M., Yuan, Z., Jin, X., Li, X., Deng, Y., Zhou, S., Niu, R., Bae, J., Park, J. B., Shi, B., & Yin, J. (2025). Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling. Nature communications, 16(1), 8642. 

• Mun, S. A.*, Yeon, G. B.*, Park, Y. H.*, Yoon, H., Ha, J. H., Jang, T. H., Hong, E., Bae, J.†, & Son, J.†  (2025). Novel oligomerization state of DinJ-YafQ complex from Vibrio cholerae-Structural and biochemical insights. International journal of biological macromolecules, 320(Pt 2), 145865. *co–first authors, †corresponding authors

• Cho, S. Y., Hwang, H., Lee, H. S., Kwon, Y., Khanh Vu, N., Baek, J. G., Jeon, M., Bae, J., Kwon, H. C., Kim, W. K., & Kwon, J. (2025). Chemical constituents from the Korean endemic plant Pseudolysimachion pusanensis inhibit diffuse-type gastric cancer cells. Biomedecine & pharmacotherapie, 186, 118005.

2023

• Park, S. W.*, Park, I. B.*, Kang, S. J., Bae, J., & Chun, T. (2023). Interaction between host cell proteins and open reading frames of porcine circovirus type 2. Journal of animal science and technology, 65(4), 698–719. *co–first authors

• Wang, X., Liu, L.†, Yue, T., Sun, Z., Bae, J., Tseng, K. F., Zhang, A., Qiao, J.†, & Fu, Y. X.† (2023). Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8+ T cells. Signal transduction and targeted therapy, 8(1), 268.  †corresponding authors

2022

• Bae, J.*, Liu, L.*, Moore, C.*, Hsu, E., Zhang, A., Ren, Z., Sun, Z., Wang, X., Zhu, J., Shen, J., Qiao, J., & Fu, Y. X. (2022). IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer. Nature cell biology, 24(12), 1754–1765. *co–first authors 

• Moore, C.*, Bae, J.*, Liu, L., Li, H., Fu, Y. X., & Qiao, J. (2022). Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunity. JCI insight, 7(17), e159479. *co–first authors 

• Lee, K. M., Lin, C. C., Servetto, A., Bae, J., Kandagatla, V., Ye, D., Kim, G., Sudhan, D. R., Mendiratta, S., González Ericsson, P. I., Balko, J. M., Lee, J., Barnes, S., Malladi, V. S., Tabrizi, S., Reddy, S. M., Yum, S., Chang, C. W., Hutchinson, K. E., Yost, S. E., … Arteaga, C. L. (2022). Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Cancer immunology research, 10(7), 829–843.

• Yang, J., Bae, J., Choi, C. Y., Choi, S. P., Yun, H. S., & Chun, T. (2022). Oral administration of Lactiplantibacillus plantarum NR16 isolated from Kimchi ameliorates murine allergic rhinitis. Letters in applied microbiology, 75(1), 152–160.

2021

• Liu, L., Chen, J., Bae, J., Li, H., Sun, Z., Moore, C., Hsu, E., Han, C., Qiao, J., & Fu, Y. X. (2021). Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells. Nature biomedical engineering, 5(11), 1261–1273.

• Hsu, E. J., Cao, X.†, Moon, B., Bae, J., Sun, Z., Liu, Z., & Fu, Y. X†. (2021). A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy. Nature communications, 12(1), 2768.  †corresponding authors

2019

• Bae, J.*, Choi*, S. P., Isono, K., Lee, J. Y., Park, S. W., Choi, C. Y., Han, J., Kim, S. H., Lee, H. H., Park, K., Jin, H. Y., Lee, S. J., Park, C. G., Koseki, H., Lee, Y. S., & Chun, T. (2019). Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression. Nature communications, 10(1), 3496. *co–first authors 

~2017

• Choi, C. Y., Kim, Y. H., Bae, J., Lee, S. J., Kim, H. K., Park, C. G., & Chun, T. (2017). Pig tissue factor pathway inhibitor α fusion immunoglobulin inhibits pig tissue factor activity in human plasma moderately more efficiently than the human counterpart. Biotechnology letters, 39(11), 1631–1638. 

• Han, J.*, Bae, J.*, Choi, C. Y., Choi, S. P., Kang, H. S., Jo, E. K., Park, J., Lee, Y. S., Moon, H. S., Park, C. G., Lee, M. S., & Chun, T. (2016). Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Autophagy, 12(12), 2326–2343. *co–first authors

• Choi, C. Y., Rho, S. B., Kim, H. S., Han, J., Bae, J., Lee, S. J., Jung, W. W., & Chun, T. (2015). The ORF3 protein of porcine circovirus type 2 promotes secretion of IL-6 and IL-8 in porcine epithelial cells by facilitating proteasomal degradation of regulator of G protein signalling 16 through physical interaction. The Journal of general virology, 96(Pt 5), 1098–1108.

• Bae, J., Lee, S. J., Park, C. G., Lee, Y. S., & Chun, T. (2014). Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling. Journal of immunology (Baltimore, Md. : 1950), 193(6), 3101–3112. 

• Lee, J. Y., Bae, J., Choi, I., Park, C. G., & Chun, T. (2014). Molecular cloning and expression analysis of pig CD7. Veterinary research communications, 38(3), 257–263.

• Bae, J., Jeong, S., Lee, J. Y., Lee, H. J., Choi, B. H., Kim, J. E., Choi, I., & Chun, T. (2013). Molecular cloning and expression analysis of pig CD138. Research in veterinary science, 95(3), 1021–1025. 

• Han, J., Rho, S. B., Lee, J. Y., Bae, J., Park, S. H., Lee, S. J., Lee, S. Y., Ahn, C., Kim, J. Y., & Chun, T. (2013). Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity. Molecules and cells, 36(5), 455–464.

• Cho, K. W., Bae, J., Lee, S. J., & Chun, T. (2013). Expression pattern and functional role of Phc2 during activation of helper T cells after antigenic stimulation. In vitro cellular & developmental biology. Animal, 49(5), 360–370.

• Lee, S. J., Bae, J., Kim, S., Jeong, S., Choi, C. Y., Choi, S. P., Kim, H. S., Jung, W. W., Imm, J. Y., Kim, S. H., & Chun, T. (2013). Saponins from soy bean and mung bean inhibit the antigen specific activation of helper T cells by blocking cell cycle progression. Biotechnology letters, 35(2), 165–173. 

• Kim, J. S., Choi, I., Lee, H. H., Lee, S. J., Na, M., Kim, S. H., Han, J., Bae, J., Choi, S. P., Kim, S. J., Park, C. G., & Chun, T. (2012). Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction. Biotechnology letters, 34(12), 2191–2197. 

• Kim, E. M., Lee, H. H., Kim, S. H., Son, Y. O., Lee, S. J., Han, J., Bae, J., Kim, S. J., Park, C. G., Park, Y., Hwang, K. W., & Chun, T. (2011). The mouse small ubiquitin-like modifier-2 (SUMO-2) inhibits interleukin-12 (IL-12) production in mature dendritic cells by blocking the translocation of the p65 subunit of NFκB into the nucleus. Molecular immunology, 48(15-16), 2189–2197.

• Park, H. J., Lee, S. J., Kim, S. H., Han, J., Bae, J., Kim, S. J., Park, C. G., & Chun, T. (2011). IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway. Molecular immunology, 48(4), 720–727.