Giulio Bonifazi

Assistant Professor at the University of Deusto

Contact:
g[dot]bonifazi[at]deusto[dot]es
Google Scholar
LinkedIn | Twitter

I am an Assistant Professor at the Faculty of Engineering of the University of Deusto (Bilbao, Spain).

I obtained a Ph.D. in Computational Neuroscience working in the Neuron-Glial Interactions Lab (led by Maurizio De Pittà), initially based at the Basque Center for Applied Mathematics (Bilbao, Spain), and later at the Krembil Research Institute (Toronto, Canada). My research focuses on the mathematical modeling of neuron-glial interactions, with a particular interest in biomarkers of Alzheimer's disease in astrocytes.

Research topics

Emergence of hyperactivity within Alzheimer’s disease trajectories

Project in collaboration with Elena Alberdi and Carlos Matute (Achucarro Basque Center for Neuroscience).

Glut_AD.mp4

Publications:

Bonifazi et al., Neurobiology of Disease, 2024. "A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity".

Posters:

14th Canadian Neuroscience Meeting (virtual): "Aβ-dependent alteration of astrocytic GLT1 expression can trigger the multistage progression of Alzheimer's disease" (#135241).
CNS*2021 (virtual): "Alteration of astrocytic glutamate transporters can drive a multistage progression of Alzheimer’s disease" (P68).
SMB 2020 Annual Meeting (virtual): "Predicting excitotoxicity at the onset of Alzheimer’s disease by a model of Aβ-dependent trafficking of astrocytic glutamate transporters" (Poster #1, NEUR subgroup).

Presentations:

June 25th, 2021. "The long and winding road towards dementia: an example from Alzheimer’s progression". BCAM (Bilbao, Spain).
March 18th, 2021. "Neuron-glia markers for the multistage progression of Alzheimer’s disease". Krembil Computational Neuroscience meeting (online).

Alzheimer’s components revealed through astrocytic gene activity

Project in collaboration with Elena Alberdi, Carlos Matute (Achucarro Basque Center for Neuroscience), and Urko M. Marigorta (CIC bioGUNE).

Posters:

2023 Annual Meeting of the Organization for Computational Neurosciences - CNS*2023 (Leipzig, Germany): “Building an atlas of astrocyte single-cells to decipher sex differences in Alzheimer’s disease” (P37).
15th Canadian Neuroscience Meeting (Toronto, Canada): "Astrocytic signatures from whole-cell genomics data to map Alzheimer's disease progression" (#140312).

Genetic, molecular, and cellular changes in astrocytic transporter trafficking during Alzheimer’s disease

Project in collaboration with Elena Alberdi and Carlos Matute (Achucarro Basque Center for Neuroscience).

Posters:

Euroglia Meeting 2021 (virtual): "Aβ-dependent GLT1 expression as neuron-glia marker for the multistage progression of Alzheimer’s disease" (T09-059D). Link: doi.org/10.1002/glia.24036
Glia in Health & Disease Meeting 2020, Cold Spring Harbor Laboratory (virtual): "In silico modeling of a tripartite synapse shows Aβ-dependent astrocytic GLT1 trafficking as a reliable marker of excitotoxicity in preclinical stages of Alzheimer’s disease" (#104).
Euroglia Meeting 2019 (Porto, Portugal): "Determinants of trafficking of glutamate transporters on perisynaptic astrocytic processes during preclinical stages of Alzheimer's disease" (T05-098C). Link: doi.org/10.1002/glia.23675

Presentations:

May 18th, 2021. "Alteration of astrocytic glutamate transporters drives tristability at the onset of Alzheimer’s disease". Canadian Computational Neuroscience Spotlight meeting (online).

Fitting of conduction velocity in myelinated axons of corpus callosum

Project in collaboration with Elena Alberdi and Carlos Matute (Achucarro Basque Center for Neuroscience).

Adapted from Quintela López, PhD Thesis, 2018.

Posters:

2019 Annual Meeting of the Organization for Computational Neurosciences - CNS*2019 (Barcelona, Spain): "Homeostatic mechanism of myelination for age-dependent variations of axonal conductance speed in the pathophysiology of Alzheimer's disease" (P89).

Modeling of aqueous humor production in ciliary epithelium during glaucoma

Project in collaboration with Giovanna Guidoboni (University of Missouri) and Riccardo Sacco (Politecnico di Milano).

Adapted from Kiel et al., Ciliary blood flow and aqueous humor production, 2011.

Publications:

Sacco, R.; Guidoboni, G.; Jerome, J.W.; Bonifazi, G.; Marazzi, N.M.; Vercellin, A.C.V.; Lang, M.S.; Harris, A. A Theoretical Approach for the Electrochemical Characterization of Ciliary Epithelium. Life 2020, 10, 8; https://doi.org/10.3390/life10020008.

Page updated

Google Sites

Report abuse