Celiac disease is a chronic autoimmune disorder that affects millions of people worldwide. It is triggered by the ingestion of gluten—a protein found in wheat, barley, and rye—leading to damage in the small intestine. Despite its prevalence, many cases go undiagnosed due to its diverse symptoms and overlap with other digestive disorders. Recent advancements in gastroenterology research are paving the way for improved diagnostics, treatments, and management strategies for celiac disease.
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Celiac disease is an autoimmune condition in which the ingestion of gluten triggers an immune response that attacks the lining of the small intestine. This leads to nutrient malabsorption, inflammation, and various gastrointestinal and systemic symptoms. If left untreated, celiac disease can result in serious complications such as osteoporosis, neurological disorders, and an increased risk of gastrointestinal cancers.
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The symptoms of celiac disease vary from person to person, making diagnosis challenging. Some individuals experience severe digestive distress, while others present with non-digestive symptoms.
Chronic diarrhea or constipation
Abdominal pain and bloating
Nausea and vomiting
Unexplained weight loss
Malabsorption and nutrient deficiencies
Fatigue and weakness
Skin rashes (Dermatitis Herpetiformis)
Joint pain and bone loss (osteoporosis)
Infertility and reproductive issues
Neurological symptoms (headaches, depression, or brain fog)
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Celiac disease is genetically linked, meaning individuals with a family history are at a higher risk. It is also associated with other autoimmune diseases, such as:
✔ Type 1 diabetes
✔ Thyroid disorders
✔ Rheumatoid arthritis
✔ Addison’s disease
Certain environmental factors, gut microbiome imbalances, and infections may also trigger the onset of celiac disease in genetically predisposed individuals.
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Celiac disease is first screened through serologic tests that detect elevated antibodies against gluten.
A biopsy of the small intestine is performed to confirm the diagnosis, as it reveals the extent of intestinal damage caused by gluten consumption.
For those with a family history, HLA-DQ2 and HLA-DQ8 genetic testing can determine susceptibility to the disease.
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The only current treatment for celiac disease is a lifelong, strict gluten-free diet. Even small amounts of gluten can trigger immune reactions and intestinal damage.
New research is exploring enzyme-based therapies that can break down gluten before it enters the small intestine. Additionally, immune-modulating drugs and gut microbiome interventions are being investigated as potential future treatments.
Studies suggest that altered gut microbiota may play a role in celiac disease. Probiotics and fecal microbiota transplants (FMT) are being researched as supportive therapies.
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Stay ahead of the latest advancements in celiac disease research, gastroenterology innovations, and autoimmune digestive disorders at the 15th World Gastroenterology, IBD & Hepatology Conference in Dubai, UAE (December 17-19, 2025).
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Join leading gastroenterologists, researchers, and healthcare professionals in shaping the future of celiac disease treatment and digestive health! 🌍✨
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