hepatocytes are injured by one or more external factors. It is the intermediate stage of transformation from various chronic liver diseases to liver cirrhosis and hepatocellular carcinoma. Its occurrence and development are related to chemokines, neuroendocrine, angiogenesis, inflammation, oxidative stress, and other pathways [17, 18]. A large volume of studies showed that if drugs can regulate the NF-κB and Nrf2 pathways simultaneously, hepatic fibrosis may improve [19, 20]. Moreover, there are a large number of components in herbal medicine that can regulate the above pathways simultaneously to improve pathological changes due to many types of fibrosis in the body [21, 22]. Biejiaxiaozheng pills, a traditional Chinese medicine compound preparation that has been used clinically for more than 30 years, have been found to show a certain curative effect on the hemorrhage of the digestive tract, portal hypertension, and hepatic fibrosis caused by hepatitis B and cirrhosis [14, 23]. However, the mechanism of action of this prescription has not been fully elucidated. In this study, CCl4, ethanol, and high-fat diet induction were used to construct a rat model of hepatic fibrosis, which was then administered Biejiaxiaozheng pills for 8 weeks to observe the therapeutic effects. At the same time, propranolol, which can decrease portal hypertension and treat hepatic fibrosis, was used as controls in this study [24, 25]. The results of this study showed that the weight of rats in the control and treatment groups gradually increased after 8 weeks of treatment. On the other hand, the weight of rats in the model group rapidly increased in the first 4 weeks before gradually decreasing in the subsequent 4 weeks. This may be due to the gradual conversion of hepatic fibrosis to cirrhosis in the model group. Liver function test results showed that liver function in the model group was significantly impaired, which presented as significant increases in plasma ALT, AST, and total bilirubin levels and significant decreases in plasma total protein and albumin levels. Conversely, transaminase and total bilirubin levels were significantly decreased in the various treatment groups, whereas plasma albumin levels were increased significantly. Plasma total protein level was significantly improved only in the propranolol and Biejiaxiaozheng pill groups. The liver function test results preliminarily showed that Biejiaxiaozheng pills show some efficacy against hepatic fibrosis in rats. HE and Masson staining of rat livers showed that the drug significantly decreased the degree of hepatic fibrosis, which presented as a significant reduction in liver pseudolobules and a decrease in fiber content. These results show that Biejiaxiaozheng pills can alleviate hepatic fibrosis directly to achieve its therapeutic effects, although these effects are weaker than those of propranolol. After confirming the effect of drugs on inhibiting and reversing hepatic fibrosis, we studied its possible mechanisms. Previous studies have shown that activation of the NF-κB pathway and inhibition of the Nrf2 pathway play a mediating role in the occurrence and development of tissue fibrosis. The active components of propranolol and various wild plants can reverse different pathological changes by improving the function of the above pathways [26, 27]. Therefore, we explored whether Biejiaxiaozheng pills act through regulating the NF-κB and Nrf2 pathways. First, the contents of inflammatory factors and antioxidant-related substances in the blood of rats were detected. The results showed that the contents of inflammatory factors such as TNF-α, IL-1β, and IL-6 and lipid peroxidation marker MDA in the model group were significantly increased but those of the antioxidants SOD, GSH, and GPx were significantly decreased. Biejiaxiaozheng pills significantly reversed these changes; however, the effect of Biejiaxiaozheng pills on inflammatory factors was weaker than that of propranolol. Moreover, the reversal effect of Biejiaxiaozheng pills was the best in terms of anti-oxidation-related indexes. In addition to blood markers, we measured the transcript levels of inflammatory factors in liver tissues. The results showed that Biejiaxiaozheng pills significantly inhibited