Research

Group Photo 2021 with International Collaborators from Brazil, Canada, China, Colombia, Greece, Iran, Pakistan, Romania, United Kingdom and United States

Overall Summary

Dr. Tse's major preoccupation has been research into the pathophysiology of cardiac arrhythmogenesis. His work has led to the identification of novel mechanisms by which immunosuppressive, anti-lipidemic and anti-diabetic medications exert protective effects against adverse remodelling, and of electrophysiological substrates underlying cardiac arrhythmias. These pre-clinical findings have provided opportunities for translational application, improving risk stratification for patients suffering from rare cardiac ion channelopathies and common cardiovascular diseases. Dr. Tse served as the Principal Investigator of population-based studies, establishing more than 20 longitudinal cohorts for Brugada syndrome, long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, arrhythmogenic right ventricular dysplasia/cardiomyopathy, valvular heart disease, heart failure, myocarditis, diabetes mellitus, hypertension, stroke, gout and COVID-19. His team has established the International Brugada Electrocardiographic Indices Consortium and published multi-national studies into Brugada syndrome. From these projects, the team has successfully developed risk models to stratify patients who are at risk of adverse events and mortality. These models have been significantly improved by the application of cutting-edge machine learning algorithms that can extract details on latent interactions between risk variables.

The team's research programme fall into three major themes:

2017-present: Comparative drug outcomes and development of predictive models to improve risk stratification in diabetes mellitus, hypertension, atrial fibrillation, stroke, myocardial infarction, valvular heart disease and heart failure using population-based datasets

2016-present: Cardiac remodelling in cardio-metabolic disorders

2008-present: Mechanisms underlying ventricular arrhythmogenesis and risk stratification in Brugada syndrome, long QT syndrome, catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia/cardiomyopathy

Visualization of the International Collaborative Network

The team has extensive collaborations with investigators from more than 18 countries: