[2026]

*Peptides for pain sensation and peptides for pain relief: Fighting fire with fire. Biomed Pharmacother. 2026 Feb:195:118990.

*The LRP1-SHP2 pathway regulates TRPV1 sensitivity in the peripheral nervous system: Insights from amyloid beta 1-42 modulation.  2026 Jan:79:461-474.

[2025]

*Ascl1-Mediated Enhancement of GABAergic Neuronal Function in Differentiated F11 Cells Under High Glucose Conditions.Biochem Biophys Res Commun. 2025 May 26:760:151721.

*Modulation of pain sensitivity by Ascl1- and Lhx6-dependent GABAergic neuronal function in streptozotocin diabetic mice.Mol Ther. 2025 Feb 5;33(2):786-804.

[2024]

*The Parkinson's disease DJ-1/PARK7 gene controls peripheral neuronal excitability and painful neuropathy. Brain. 2024 Nov 2:awae341.

*GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation. Exp Mol Med. 2024 Nov;56(11):2449-2464

*Current insights and therapeutic strategies for targeting TRPV1 in neuropathic pain management.Life Sci. 2024 Oct 15;355:122954.

*STING recognition of viral dsDNA by nociceptors mediates pain in mice.Brain Behav Immun. 2024 Oct;121:29-42.

*Functional Role of Piezo1 in the Human Eosinophil Cell Line AML14.3D10: Implications for the Immune and Sensory Nervous Systems.Biomolecules. 2024 Sep 14;14(9), 1157.

*Irisin alleviates CFA-induced inflammatory pain by modulating macrophage polarization and spinal glial cell activation.Biomed Pharmacother. 2024 Sep;178:117157.

*Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets. Front Physiol. 2024 Jul 3:15:1413902.

*Specific transcription factors Ascl1 and Lhx6 attenuate diabetic neuropathic pain by modulating spinal neuroinflammation and microglial activation in mice.Biomed Pharmacother. 2024 Apr:173:116392.

*Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice. Brain Behav Immun. 2024 Mar:117:51-65

*Inflammation-Targeting Mesenchymal Stem Cells Combined with Photothermal Treatment Attenuate Severe Joint Inflammation.Adv Mater. 2024 Mar;36(11):e2304333.

*Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment.Biomolecules. 2024 Jan 15;14(1):107.

[2023]

*Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain.Brain Behav Immun. 2023 Oct:113:401-414.

*Role of Resolvins in Inflammatory and Neuropathic Pain.Pharmaceuticals (Basel). 2023 Sep 27;16(10):1366.

*Design and Development of High-Entropy Alloys with a Tailored Composition and Phase Structure Based on Thermodynamic Parameters and Film Thickness Using a Novel Combinatorial Target.ACS Omega. 2023 Jul 26;8(31):28333-28343

*Epidural and Intrathecal Drug Delivery in Rats and Mice for Experimental Research: Fundamental Concepts, Techniques, Precaution, and Application.Biomedicines . 2023 May 10;11(5):1413

*Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine.Int J Mol Sci. 2023 Apr 26;24(9):7897.

[2022]

*Portable Cold Atmospheric Plasma Patch-Mediated Skin Anti-Inflammatory Therapy.Adv Sci (Weinh). 2022 Dec;9(34):e2202800.

*Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain,Int J Mol Sci. 2022 Dec 13;23(24):15854

*Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development, Int J Mol Sci. 2022 May 21;23(10):5772

[2021]

*Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research,International journal of molecular sciences, 2021 Nov 9;22(22) 

*Transient Receptor Potential Channels and Botulinum Neurotoxins in Chronic Pain,International journal of molecular sciences, 2021 Oct 29;14:772719 

*Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1),FRONTIERS IN MOLECULAR NEUROSCIENCE,2021 Jun 18;14:643483 

*Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021 May

*Functional Importance of Transient Receptor Potential (TRP) Channels in Neurological Disorders, Frontiers in Cell and Developmental Biology,2021 Mar

*Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model, CELLS,2021 Mar

*Comparison of therapeutic effects between topical 8-oxo-2′-deoxyguanosine and corticosteroid in ocular alkali burn model. Scientific Reports 2021 Mar

*Resolvin D3 Promotes Inflammatory Resolution, Neuroprotection, and Functional Recovery After Spinal Cord Injury. Molecular Neurobiology. 2021 Jan

*The Role of TRP Channels and PMCA in Brain Disorders: Intracellular Calcium and pH Homeostasis.. Front Cell Dev Biol. 2021 Jan

[2020]

*Co-application of eugenol and QX-314 elicits the prolonged blockade of voltage-gated sodium channels in nociceptive trigeminal ganglion neurons, Biomolecules, 2020 Nov 5;10(11):1513.

*Enhanced Efficacy of Photodynamic Therapy by Coupling a Cell-Penetrating Peptide with Methylene Blue, Int J Nanomedicine. 2020 Aug 6;15:5803-5811.

*Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis, Theranostics, 2020 Oct 26;10(26):12111-12126.

*ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics, Sci Transl Med, 2020 Oct 21;12(566):eaax3993

*Adipose Tissue-Derived Stem Cells Alleviate Cold Allodynia in a Rat Spinal Nerve Ligation Model of Neuropathic Pain, Stem Cells Int, 2020 Oct 12;2020:8845262.

*Synthesis of Graphene Oxide Using Atmospheric Plasma for Prospective Biological Applications, Int J Nanomedicine, 2020 Aug 6;15:5813-5824.

*Functional expression of piezo1 in dorsal root ganglion (DRG) neurons, Int J Mol Sci, 2020 May 28;21(11):3834.

*Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinla Cord Injury, J Neurosci, 2020 Feb 26;40(9):1943-1955.

*Tannin Inhibits Histamine and SLIGRL-NH2-Induced Itch via TRPV1 and TRPA1 Signaling Pathway, International Journal of Pain,2020 Jun 11(1):11-20

*Resolvins: Potent Pain Ingibiting Lipid Mediators via Transient Receptor Potential Regulation. Front Cell Dev Biol. 2020 Dec 10;8:584206.

[2019]

*The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration, Int J Mol Sci; 2019 Nov 21;20(23):5849.

*Apoptotic Iysosomal proton sponge effect in tumor tissue by cationic gold nanorods, Nanoscale. 2019 Nov 14;11(42):19980-19993.

*Ion Channels Involved in Tooth Pain, Int J Mol Sci. 2019 May 8;20(9):2266

*Dexmedetomidine Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels Currents inTrigeminal Ganglion Neurons. Int J Pain. 2019 Dec;10(1):1-9.

[2018]

*Differential Inhibition of Nav1.7 and Neuropathic Pain by Hyvridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7, Neurosci Bull. 2018 Feb;34(1):22-41.

*Peripheral GABAA receptor-mediated signaling facilitates persistent inflammatory hypersensitivity, Neuropharmacology. 2018 Jun;135:572-580.

*Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic anti-depressants in mice, J Allergy Clin Immunol. 2018 Oct;142(4):1349-1352.e16.

*Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via alpha 2-Adrenoceptors inTrigeminal Ganglion Neurons, Mediators Inflamm. 2018 Sep 2;2018:1782719.

*miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus, Neuron. 2018 Aug 8;99(3):449-463.e6.

*Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons, Korean J Physiol Pharmacol, 2018 Mar;22(2):173-182.

*Nucleic Acid-Binding Fluorochromes and Nanoparticles: Structural Aspects of Binding Affinity and Fluorescence Intensity, MACROMOLECULAR RESEARCH,201826(2)204-209

*Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms, Neurosci Bull. 2018 Feb;34(1):13-21.

*Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel, Neurosci Bull. 2018 Feb;34(1):4-12.

[2017]

*Photodynamic therapy by conjugation of cell-penetrating peptide with fluorochrome, Int J Nanomedicine. 2017 Nov 10;12:8185-8196.

*Two Phase Modulation of NH4+ Entry and CI-/HCO3- Exchanger in Submandibular Glands Cells by Dexmedetomidine, Front Physiol. 2017 Mar 1;8:86.

*Extracellular ATP Induces Calcium Signaling in Odontoblasts, J Dent Res. 2017 Feb;96(2):200-207.

*Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain, J Dent Res. 2017 Feb;96(2):200-207.

*Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis, Nature. 2017 Nov 8;551(7679):192-197.

*PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1, Nat Neurosci. 2017 Jul;20(7):917-926.

*Piezo2 Expression in Mechanosensitive Dental Primary Afferent Neurons, J Dent Res. 2017 Jul;96(8):931-937.

*TRPM2 contributes to LPC-induced intracellular Ca2+ influx and microglial activation, Biochem Biophys Res Commun. 2017 Apr 1;485(2):301-306.

*Acute inflammation reveals GABA A receptor-mediated nociception in mouse dorsal root ganglion neurons via PGE 2 receptor 4 signaling, Physiol Rep. 2017 Apr;5(8):e13178.

*Extracellular ATP Induces Calcium Signaling in Odontoblasts, J Dent Res. 2017 Feb;96(2):200-207.

*A critical rol of spinal Shank2 proteins in NMDA-induced pain hypersensitivity, Mol Pain. 2017 Jan;13:1744806916688902.

TRPV1 활성 매개 질환 치료용 약학적 조성물

1. 대한민국(2024.02.20) 10-2024-0024661 특허출원

통증 치료용 의약 조성물

1. 대한민국(2024.02.20) 10-2024-0024646 특허출원

유제놀을 유효성분으로 함유하는 아토피성 피부염의 예방 또는 치료용 조성물 (Composition comprising eugenol for preventing or  treating atopic dermatitis)

1. 대한민국 (2015.04.02) 10-1510595 특허등록

2. 호주 (2015.06.04) 2015100665 특허등록

3. PCT (2014.10.24) PCT/KR2014/010052 9개국가 출원완료

유제놀을 포함하는 기계적 이질통 치료용 약학적 조성물 (Method For Treating Mechanical Allodynia Comprising Administration of Eugenol)

1. 대한민국 (2014.01.24) 10-1357980 특허등록

2. 미국 (2012.06.12) 13/494,859 특허출원

TRPC3의 억제제를 유효성분으로 포함하는 가려움증 치료용 약제학적 조성물

1. 대한민국 (2018.03.16) 10-1841238 특허등록

TRPV1 활성 매개 질환 치료용 약학적 조성물

1. 대한민국 (2020.01.20) 10-2020-0007433 특허출원

유제놀을 유효성분으로 함유하는 아토피성 피부염의 예방 또는 치료용 조성물

대상기관  : YD생명과학

이전일시 : 2014.07.07(대한민국 특허),2015.06.19(해외 특허)