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Programma Scientifico
Giovedì, 2 Ottobre 2025
Giovedì, 2 Ottobre 2025
Sala Ricevimento Best Western Plus Hotel Perla del Porto.
14:00 - 15:00
Registrazione dei partecipanti
Registrazione dei partecipanti
15:00 - 15:30
Apertura del Meeting
Apertura del Meeting
SESSIONE I
Chairs: Anna Artese, Bruno Pagano
15:30 - 16:15
Lettura Plenaria
Lettura Plenaria
Prof. Janez Plavec
Prof. Janez Plavec
"Unravelling G-quadruplex DNA Dynamics via NMR: Modulation by Citosine Methylation, Ligands, and Proteins"
16:15 - 16:35
Sabrina Vailati
Sabrina Vailati
"Guanine Clamps for a Topology-Specific
Disruption of G-Quadruplexes"
16:35 - 16:55
Alessandro D'Urso
Alessandro D'Urso
"Exploiting porphyrins to induce antiparallel to
parallel transition of RNA G-quadruplex"
17:00 - 17:20
Coffee break
Coffee break
SESSIONE II
Chairs: Claudia Sissi, Paolo Mariani
17:20 - 17:40
Katia Grillone
Katia Grillone
"Targeting G4 Regions Of lncRNAs As Anti-Cancer Therapy: Innovative Approach For Drugging The “Undragabble”"
17:40 - 18:00
Daniele Belletto
Daniele Belletto
"From inactive Pt(II) complex to effective G-Quadruplex stabilizer. Atomistic modelling of an adaptive binding mechanism for selective anticancer therapy"
18:00 - 18:20
Antonio Curcio
Antonio Curcio
"Stopping It Before It Starts: Disrupting PARP1 Expression Targeting a Non-Canonical G-Quadruplex in Multiple Myeloma Cancer Cells"
18:20 - 18:40
Simona Marzano
Simona Marzano
"Unveiling The Structural Basis Of C-Kit2 G-Quadruplex DNA Binding By An Anticancer Benzimidazole Derivative"
18:40 - 19:00
Emilia Sicilia
Emilia Sicilia
"Computational insights on a redox-activated platinum(IV)-salphen complex as G-Q binder"
19:00 - 19:20
Federica Moraca
Federica Moraca
"Harnessing Peptide Nucleic Acids (Pna) To Target The Bcl-2 Promoter Sequence: From G-Quadruplex To Non-Canonical Dna₂-Pna Heterotriplex"
20:30
Cena
Cena
Venerdì, 3 Ottobre 2025
Venerdì, 3 Ottobre 2025
Sala Ricevimento Best Western Plus Hotel Perla del Porto
Aula H - Università degli studi "Magna Graecia" di Catanzaro
SESSIONE III
Chairs: Jussara Amato, Roberta Rocca
09:30 - 10:15
Lettura Plenaria
Lettura Plenaria
Prof. Marco Di Antonio
Prof. Marco Di Antonio
"The untold story behind G-quadruplexes and trascriptional control"
10:15 - 10:35
Federico Dinoi
Federico Dinoi
"The role of a G-quadruplex motif in SIRT1 regulation"
10:35 - 10:55
Roberto Improta
Roberto Improta
"The influence of the loop bases on the spectral signature of I-motifs: insights from quantum-mechanical calculations"
10:55 - 11:15
Francesca Romano
Francesca Romano
"Deciphering The Cellular Impact Of DNA G-Quadruplex Ligands Through Integrative Multi-Omics Analysis"
11:15 - 11:45
Coffee break
Coffee break
SESSIONE IV
Chairs: Concetta Giancola, Francesca Ripanti
11:45 - 12:05
Luigi Petraccone
Luigi Petraccone
"A Quadruplex-Triplex Switch in the SARS-CoV-2 Genome"
12:05 - 12:25
Martina Fiabane
Martina Fiabane
"Structure-Based Ligandability Exploration of a G-Quadruplex-Forming Sequence from the Pseudomonas aeruginosa Genome"
12:25 - 12:45
Filippo Mattellone
Filippo Mattellone
"Identification Of Non-Canonical Nucleic Acid Structures In Flavivirusvirus-Infected Cells As Novel Antiviral Targets"
12:45 - 13:05
Matilde Solange Francesca Cannistrà
Matilde Solange Francesca Cannistrà
"Structure Based Virtual Screening of ligands Targeting the LTR-III sequence for Anti-HIV-1 Drug Discovery"
13:10
Pranzo
Pranzo
SESSIONE V
Chairs: Nunzia Iaccarino, Antonio Randazzo
15:00 - 15:45
Lettura Plenaria
Lettura Plenaria
Prof. Naoki Sugimoto
Prof. Naoki Sugimoto
"“To B or not to B” in Nucleic Acids Chemistry"
15:45 - 16:05
Erica Salvati
Erica Salvati
"Modulating TERRA G-quadruplexes with ligands: Impact on telomere DNA:RNA hybrids and ALT mechanisms"
16:05 - 16:25
Ernesto Mucenji
Ernesto Mucenji
"Screening and validation of potential new hit compounds for MALAT1 triplex targeting in melanoma"
16:25 - 16:45
Luca Bertini
Luca Bertini
"Multimeric G-Quadruplex Structures: Insights from SAXS-guided Extremely Coarse-Grained Simulations"
16:45 - 17:00
Coffee break
Coffee break
17:00
Evento Sociale
Evento Sociale
Sabato, 4 Ottobre 2025
Sabato, 4 Ottobre 2025
Sala Ricevimento Best Western Plus Hotel Perla del Porto.
SESSIONE VI
Chairs: Sara N. Richter, Daniela Montesarchio
09:30 - 10:15
Lettura Plenaria
Lettura Plenaria
Prof. Katrin Paeschke
Prof. Katrin Paeschke
"G4 and its contribution to stress response"
10:15 - 10:35
Alessia Pepe
Alessia Pepe
"G-hydrogel as a dual drug delivery system:
formation kinetics by time-resolved approaches"
10:35 - 10:55
Andrea Criscuolo
Andrea Criscuolo
"Aptamer–Decorated Nanoparticles For Efficient Hmgb1 Inhibition"
10:55 - 11:15
Rodrigo Fernandes
Rodrigo Fernandes
"Guanosine and GMP G-quadruplexes for molecular-level consolidation of heritage paper"
11:15 - 11:45
Coffee break
Coffee break
SESSIONE VII
Chairs: Domenica Musumeci, Stefano Alcaro
11:45 - 11:55
Martina Brigida Romanello
Martina Brigida Romanello
"Mechanistic Insights Into The Interaction Of A Disubstituted Anthracene-Propargylamine Derivative With G-Quadruplex"
11:55 - 12:05
Marta Cozzaglio
Marta Cozzaglio
"Beyond The Cytoskeleton: Vimentin As An RNA G-Quadruplex-Binding Protein"
12:05 - 12:25
Premio Gian Piero Spada
Premio Gian Piero Spada
Anna Di Porzio
"Unlocking the potential of G-quadruplex ligands to tackle uL3-mediated chemoresistance in colorectal cancer"
12:25 - 13:00
OPEN DISCUSSION Chair:Stefano Alcaro
OPEN DISCUSSION Chair:Stefano Alcaro
"Quadruplexes and Beyond: A Dialogue Between Structure, Function, and Applications"
13:00
Conclusione del meeting
Conclusione del meeting
Terrazza "Matteo Saliceti"
Terrazza "Matteo Saliceti"
Lungomare Pugliese
Lungomare Pugliese
15:45 - 15:55
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