Toshinori Fujie Research Group

Laboratory for Integrated NanoBioElectronics

Nexus of Nano, Bio and Electronics for Human Healthcare

Welcome to Fujie Lab @ Institute of Science Tokyo!

We are envisaging the development of innovative therapeutics and diagnostics.

大学院生募集中

藤枝研では大学院生を募集しています。藤枝（t_fujie ＠ life.isct.ac.jp）までお気軽にお問い合わせ下さい。

キーワード：ナノバイオマテリアル，組織工学，細胞治療，ウェアラブル・インプランタブルデバイス

大学院入学案内

https://www.titech.ac.jp/graduate_school/admissions/

https://www.titech.ac.jp/contact/

https://educ.titech.ac.jp/bio/news/2019_05/057409.html

https://www.youtube.com/watch?v=acrwht7annU&t=4s

https://www.youtube.com/watch?v=BtJ5lbGl2tg

News

News 2025

2025.8.4

Award Announcement

Edo received the Best Master's Thesis Presentation Award from the Course of Human Centered Science and Biomedical Engineering! Congratulations!!

2025.6.3

New paper is out!

Masato and Hajime contributed to the development of batter-free wireless ion sensors. This work has been achieved under the collaboration with Prof. Tatsuhiro Goda in Toyo University.

Ito, Y., Yamamoto, O., Saito, M., Fujita, H., Fujie, T., Goda, T. Battery-Free Wearable Sensors with Ion-Selective Electrodes Embedded in Passive Resonant Antenna Circuits for Wireless Sweat Monitoring. Sens. Actuators B Chem., in press, 138098 (2025). (DOI: 10.1016/j.snb.2025.138098)

https://www.sciencedirect.com/science/article/abs/pii/S0925400525008743

2025.5.30

New paper is out!

Masato, Sota, Ran, Kon developed a flexible thin-film heater using lase-induced graphene for cancer thermotherapy.

Saito, M., Harada, S., Imai, R., Son, K., Fujie, T*(Corresponding). Flexible Thin-Film Heater Composed of Laser-Induced Graphene and Poly(D, L-Lactic Acid) with Electro- and Photo-Thermal Properties toward Cancer Thermotherapy. Adv. Electron. Mater., 2500062 (2025). (DOI: 10.1002/aelm.202500062)

https://advanced.onlinelibrary.wiley.com/doi/10.1002/aelm.202500062

2025.5.15

Social Gathering Party

We enjoyed the social gathering party with students from Prof. Tanaka, Prof. Yanaka and Prof. Kadonosono Groups.

2025.5.1

New paper is out!

Toshi contributed to the development of tissue-engineering scaffolds with piezoelectric nanomaterials. This work has been achieved under the collaboration with Prof. Leonardo Ricotti in the Scuola Superiore Sant'Anna, Italy.

Boccoli, L., Drago, E., Cafarelli, A., Vannozzi, L., Sciullo, A., Iberite, F., Kerdegari, S., Fujie, T., Gruppioni, E., Canale, C., Ricotti, L. Micropatterned Styrene–Butadiene–Styrene Thin Films Doped with Barium Titanate Nanoparticles: Effects on Myoblast Differentiation. ACS Biomater. Sci. Eng., in press (2025). (DOI: 10.1021/acsbiomaterials.4c02468)

https://pubs.acs.org/doi/10.1021/acsbiomaterials.4c02468

2025.4.30

BBQ Party

We enjoyed BBQ under the beautiful weather.

2025.4.1

Members Updated!

Welcome Hina Ishiyama to our group!

News 2024

2025.3.26

Graduation Ceremony

Keita, Sota and Fumiya received Bachelor's Degrees, Tasuku, Zichen and Daiki received Master's Degrees, and Masato received Doctor Degree from Science Tokyo. Masato is the second PhD degree holder from the Fujie Group!

Congratulations and good luck on your prestigious future!!

2025.3.14

Award Announcement

Masato received the Young Scientist Presentation Award in The 85th JSAP Autumn Meeting 2024! Congratulations!!

https://www.jsap.or.jp/young-scientist-presentation-award/recipients57

Conference Information

2025.3.26-29, 日本化学会第105春季年会(2025)

https://pub.confit.atlas.jp/ja/event/csj105th

[1] 寺井健人, 孫健, Kevin Plaxco, 藤枝俊宣.「薄膜金電極を用いた電気化学アプタマーセンサの物性評価とリアルタイム測定」日本化学会第105春季年会(2025) (2025.3.28., 大阪).　

[2] Eduardus Ariasena, 藤枝俊宣.「Design and Fabrication of Inkjet-Printed Microelectrodes for Electrochemical Sensors of Extracellular Components」日本化学会第105春季年会(2025) (2025.3.28., 大阪).

[3] 鈴木麻紘, 遠藤貴南, 圖師菜々美, 白木伸明, 粂昭苑, 藤枝俊宣.「多孔質ナノシートを搭載した細胞封入デバイス開発と膵島細胞移植への応用」日本化学会第105春季年会(2025) (2025.3.28., 大阪).

[4] 堀祐輔, 堀井辰衛, 増田真二, 藤枝俊宣.「単層カーボンナノチューブからなる葉面貼付型の透明超薄膜生体電極の開発と植物健康モニタリングへの応用」日本化学会第105春季年会(2025) (2025.3.27., 大阪).

2025.3.16, 第66回日本植物生理学会年会

https://jspp.org/annualmeeting/66/

[1] 堀祐輔, 堀井辰衛, 増田真二, 藤枝俊宣.「植物健康モニタリングに向けた葉面貼付型の透明超薄膜生体電極の開発」第66回日本植物生理学会年会 (2025.3.16., 金沢).

2025.3.3

Visiting Researcher from Italy

We warmly welcome Ms. Maria Cristina Ceccarelli from Dr. Gianni Ciofani Group in the Intalian Institute of Technology! We will conduct the collaboration research in organ-on-a-chip for next months.

Conference Information

2025.3.4, Tokyo Biodesign Healthtech Innovation day 2025

https://japanhealthtechsummit.peatix.com/

Toshi will attend the panel session to discuss about the social implementation of medical devices.

2025.2.21

Members Updated!

Welcome Reijiro Kotera, Taisei Watanabe, and Yota Kashima to our group!

2025.2.18

Visiting Researcher from Germany

We warmly welcome Ms. Jiyao Yu from Dr. Christopher Synatschke Group in Max Planck Institute for Polymer Research! We will conduct the collaboration research in polyphenol nanofilms for next weeks.

2025.2.17

New paper is out!

Nanami, Megumi and Mahiro developed the world-thinnest transmembrane made from polycarbonate for cell-encapsulated device. This work has been achieved under the collaboration with Profs. Shoen Kume and Nobuaki Shiraki in the Institute of Science Tokyo.

Zushi, N., Takuma, M., Endo, N., Suzuki, M., Wu, Y., Shiraki, N., Kume, S., Fujie, T*(Corresponding). Multilayered Freestanding Porous Polycarbonate Nanosheets with Directed Protein Permeability for Cell-Encapsulated Device. ACS Appl. Bio Mater., in press (2025). (DOI: 10.1021/acsabm.4c01446)

https://pubs.acs.org/doi/10.1021/acsabm.4c01446

2025.2.14

Award Announcement

Zichen received the Best Master's Thesis Presentation Award from the Course of Human Centered Science and Biomedical Engineering! Congratulations!!

2025.1.30

New paper is out!

Daiki, Hajime, Yosuke and Tatsuhiro developed unique supramolecular adhesives leveraging carbodiimide-to-urea conversion and gallic acid. This work has been achieved under the collaboration with Prof. Takeshi Hata in the Instiute of Science Tokyo.

Sekita, D., Fujita, H., Mizuno, Y., Horii, T., Hata, T., Fujie, T*(Corresponding). Facile coating of low-molecular-weight stretchable adhesive films leveraging carbodiimide-to-urea conversion and gallic acid for enhanced adhesion. Mater. Adv., in press (2025). (DOI: 10.1039/D4MA01102C)

https://pubs.rsc.org/en/Content/ArticleLanding/2025/MA/D4MA01102C

2025.1.23

New paper is out!

Masato contributed to the development of transferring strained graphene sheets using an elastomer nanosheet to enhance the resonance characteristics of a graphene resonator. This work has been achieved under the collaboration with Prof. Tatsuro Goda in Toyo University and Prof. Kazuhiro Takahashi in Toyohashi University of Technology.

Kato,　M., Arano, K., Saito, M., Fujie, T., Imaizumi, Y., Goda, T., Choi, YJ., Noda, T., Sawada, K., Takahashi, K. Elastomer-assisted graphene transfer technique for enhanced resonance characteristics in chemisorption-based graphene resonant mass sensors, Nanoscale, in press (2025). (DOI: 10.1039/D4NR04571H)

https://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr04571h/unauth

2024.12.5

Award Announcement

Mahiro received the Best Presentation Award in the Research Planning for Master Thesis I from the Course of Life Science and Technology! Congratulations!!

2024.12.1

Promotion

Toshi has been promoted to be Professor of the School of Life Science and Technology, Institute of Science Tokyo. Many thanks to the constant support and kind help from mentors, supervisors, collaborators, staff, alumni, students and family! Let's move on to the next stage!

Conference Information

2024.11.27, プラスチック成形加工学会第32回秋季大会

https://pub.confit.atlas.jp/ja/event/seikeikakousympo2024

[1] 藤枝俊宣.「薄膜エレクトロニクスによる生体融合への挑戦」プラスチック成形加工学会第32回秋季大会 (2024.11.27., 那覇).

[2] 堀井辰衛，石岡将史，小寺賢，藤枝俊宣.「裏表で異なる接着力を発現する薄型エラストマーヤヌスシートの開発」プラスチック成形加工学会第32回秋季大会 (2024.11.27., 那覇).

2024.11.23, 35th 2024 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2024)

https://www.mein.nagoya-u.ac.jp/mhs/MHS2024-Top.html

[1] Fujie, T. Bio-Integrated Flexible Electronics for Directing Living Body, 35th 2024 International Symposium on Micro-NanoMechatronics and Human Science (MHS2024) (2024.11.23., Nagoya).

2024.11.15, International Symposium on Biotechnology and Biomedicine

[1] Fujie, T. Thin Film Electronics for Bio-Integrated Medical Devices, International Symposium on Biotechnology and Biomedicine (2024.11.15., Ulaanbaatar).

Conference Information

2024.11.15, 37th International Microprocesses and Nanotechnology Conference (MNC 2024)

https://imnc.jp/2024/

[1] Gao, Z. Horii, T., Ito, T., Tanaka, H., Fujie, T. Lightweight and Ultra-Flexible Capacitive Strain Sensors for Biomimetic Wing Dynamics, 37th International Microprocesses and Nanotechnology Conference (MNC 2024) (2024.11.15., Kyoto).

2024.10.28, 日本バイオマテリアル学会シンポジウム2024

https://jsb-symposium2024.com/

[1] 藤枝俊宣，田熊めぐみ，圖師菜々美，藤田創.「PDMS ナノシートを搭載した細胞封入デバイスの開発と血管新生作用」日本バイオマテリアル学会シンポジウム2024 (2024.10.28., 仙台).

2024.10.22

New paper is out!

Tasuku and Yosuke developed dynamically crosslinked hydrogels with rich gallol groups, which enables zero-order release of proteins over 2 weeks. This work has been achieved under the collaboration with Prof. Tetsuya Kitaguchi in Instiute of Science Tokyo. This is a special issue in celebration of Prof. Hiroyuki Nishide's 77th Birthday.

Yamada, T., Mizuno, Y., Tian, L., Kitaguchi, T., Fujie, T*(Corresponding). Dynamically Crosslinked Hydrogels Composed of Carboxymethyl Chitosan and Tannic Acid for Sustainable Release of Encapsulated Protein. Macromol. Chem. Phys., 2400220 (2024). (DOI: 10.1002/macp.202400220)

https://onlinelibrary.wiley.com/doi/10.1002/macp.202400220?af=R

2024.10.1

Members Updated!

Welcome Jin Seki and Takaharu Nishiyama to our group!

Conference Information

2024.8.26, The 5th International Symposium on Polymer Ecomaterials (PEM2024)

https://pem2024.casconf.cn/page/1790985438459203585

[1] Fujie, T. Tissue-Interfaced Electronics for Advancing Medical Healthcare, The 5th International Symposium on Polymer Ecomaterials (PEM2024) (2024.8.26., Changchun).

2024.10.1

Institute of Science Tokyo

Our institute has changed the name. Thank you Tokyo Tech, and hello SCIENCE TOKYO!

2024.9.18

Award Announcement

Edo received the Best Presentation Award in the Research Planning for Master Thesis I from the Course of Human Centered Science and Biomedical Engineering! Congratulations!!

Conference Information

2024.9.16-20, 第85回応用物理学会秋季学術講演会

https://meeting.jsap.or.jp/

[1] 堀祐輔, 堀井辰衛, 増田真二, 藤枝俊宣.「植物葉面に貼付可能な透明超薄膜電極の開発と生体電位応答の計測」第85回応用物理学会秋季学術講演会 (2024.9.16., 新潟).

[2] 齋藤優人，登倉大貴, 横式康史, 德田崇, 野本貴大, 藤枝俊宣.「光線力学療法に向けた薄膜状発光デバイスの開発と抗腫瘍能評価」第85回応用物理学会秋季学術講演会 (2024.9.16., 新潟).

[3] 堀井辰衛, 小此木葵衣, 藤田創, Zichen Gao, 佐藤峻, 岩瀬英治, 藤枝俊宣. 「柔軟性を有する貼付型薄膜湿度センサの開発と植物の蒸散活動計測」第85回応用物理学会秋季学術講演会 (2024.9.17., 新潟).

[4] 寺井健人, 孫健, 藤枝俊宣.「薄膜金電極を用いた電気化学アプタマーセンサのセンシング能評価」第85回応用物理学会秋季学術講演会 (2024.9.19., 新潟).

Conference Information

2024.8.26, The 5th International Symposium on Polymer Ecomaterials (PEM2024)

https://pem2024.casconf.cn/page/1790985438459203585

[1] Fujie, T. Tissue-Interfaced Electronics for Advancing Medical Healthcare, The 5th International Symposium on Polymer Ecomaterials (PEM2024) (2024.8.26., Changchun).

2024.8.23

Award Announcement

Toshi received the SPSJ Asahi Kasei Award from The Society of Polymer Science, Japan (2024). The award lecture “Development of Bio-Integrated Devices by Implementation of Printed Electronics on Polymeric Thin Films” will be organized in the 73rd Symposium on Macromolecules in Niigata.

https://www.spsj.or.jp/nus_im/webapp/data_file/240719053607_8.pdf

https://www.titech.ac.jp/news/2024/069835

[1] 「高分子薄膜へのプリンテッドエレクトロニクスの実装による生体融合型デバイスの開発」第73回高分子討論会 (2024.9.26., 新潟).

https://main.spsj.or.jp/tohron/73tohron/

2024.6.20

New paper is out!

Tatsuhiro, Kai, Marimo and Kei developed skin-confromable bioelectrodes made from fibrous network of single-walled carbon nanotubes.

Horii, T., Yamashita, K., Ito, M., Okada, K., Fujie, T*(Corresponding). Skin-Conformable Electrodes with Superior Water Vapor Permeability by Fibrous Network of Single-Walled Carbon Nanotubes Assembled on Elastomeric Ultrathin Films. NPG Asia Mater., 16, 33 (2024). (DOI: 10.1038/s41427-024-00553-9)

https://www.nature.com/articles/s41427-024-00553-9

https://www.titech.ac.jp/news/2024/069488

https://www.nikkei.com/article/DGXZQOSG268NI0W4A620C2000000/

2024.6.9

New paper is out!

Masato, Hajime and Tatsuhiro contributed to the development of R2R process for continuous production of stretchable electronics with liquid metal wiring. This work has been achieved under the collaboration with Prof. Hiroki Ota in Yokohama National University.

Kawakami, H., Nagatake, K., Ni, S., Nakamura, F., Takano, T., Murakami, K., Ohara, I., Isano, Y., Matsuda, R., Suwa, H., Higashi, R., Kanto, M., Saito, M., Fujita, H., Araki, T., Ozaki, S., Ueno, K., Horii, T., Fujie, T., Ota, H. R2R-Based Continuous Production of Patterned and Multilayered Elastic Substrates with Liquid Metal Wiring for Stretchable Electronics. Adv. Mater. Technol., in press (2024). (DOI: 10.1002/admt.202400487)

https://onlinelibrary.wiley.com/doi/10.1002/admt.202400487

Conference Information

2024.6.8, 第 47 回日本バイオレオロジー学会年会

https://biorheology47.w.waseda.jp/

[1] 藤枝俊宣.「薄膜エレクトロニクスが拓く生体融合技術」第47回日本バイオレオロジー学会年会・日本バイオレオロジー・リサーチフォーラム (2024.6.8., 東京).

2024.6.1

New paper is out!

Megumi, Hajime and Nanami developed a cell encapsulation device equipped with an intrinsically semi-permeable PDMS nanosheet. This work has been achieved under the collaboration with Profs. Ryuichi Azuma and Tomoharu Kiyosawa in National Defense Medical College.

Takuma, M., Fujita, H., Zushi, N., Nagano, H., Azuma, R., Kiyosawa, T., Fujie, T*(Corresponding). Intrinsically Semi-Permeable PDMS Nanosheet Encapsulating Adipose Tissue-Derived Stem Cells for Enhanced Angiogenesis. Biomater. Sci., in press (2024). (DOI: 10.1039/D4BM00460D)

https://pubs.rsc.org/en/content/articlelanding/2024/bm/d4bm00460d

Conference Information

2024.5.26-31, 12th World Biomaterials Congress (WBC)

https://wbc2024.com/

[1] Fujie, T. Tissue-interfaced electronics with multi-layered structure, 12th World Biomaterials Congress (WBC2024) (2024.5.30., Daegu).

[2] Sekita, D. Mizuno, Y., Fujita, H., Fujie, T. Facile fabrication of thin-film adhesives containing bio-inspired gallol for enhanced material adhesion, 12th World Biomaterials Congress (WBC2024) (2024.5.28., Daegu).

[3] Yamada, T., Mizuno, Y., Fujie, T. Fabrication of 3D printable hydrogels composed of carboxymethyl chitosan and tannic acid for proten collection and release, 12th World Biomaterials Congress (WBC2024) (2024.5.30., Daegu).

[4] Saito, M. Nomoto, T., Yokoshiki, Y., Tokuda, T., Fujie, T. Development of wireless light-emitting devices based on polymeric thin films and evaluation of their hyper-localized photosensitization, 12th World Biomaterials Congress (WBC2024) (2024.5.28., Daegu).

2024.5.11

Announcement

We will open our lab to the public during the Suzukake Science Day 2023 on May 11-12.
Let's enjoy to see what's going on in the Fujie Lab!
5月11日－12日開催の「すずかけサイエンスデイ2023」で研究室公開をします。
この機会に藤枝研の最新テクノロジーを御覧ください。

多くの方にお立ち寄り頂きましてありがとうございました！
https://www.titech.ac.jp/event/2024/069080

2024.4.16

New paper is out!

Megumi contributed to the development of porous nanosheets for localization of uncultured stromal vascular fraction cells on full-thickness wound skin. This work has been achieved under the collaboration with Dr. Shimpo Aoki and Prof. Indranil Sinha in Harvard Medical School, Brigham and Women’s Hospital.

Aoki, S., Endo, Y., Guo, C., Wu, M., Kim, A., Takuma, M., Mroueh, J., Weber, L., Fujie, T., Nuutila, K., Sinha. I. Nanosheet Promotes Chronic Wound Healing by Localizing Uncultured Stromal Vascular Fraction Cells. Adv. Wound Care, in press (2024). (DOI: 10.1089/wound.2024.0014)

https://www.liebertpub.com/doi/abs/10.1089/wound.2024.0014

Conference Information

2024.4.22-26, 2024 MRS Spring Meetings & Exhibit.

https://www.mrs.org/meetings-events/spring-meetings-exhibits/2024-mrs-spring-meeting

[1] Fujie, T. Tissue-Interfaced Electronics for Directing Biological Functions, 2024 MRS Spring Meetings & Exhibit. (2024.4.25., Seattle).

2024.4.5, 日本表面真空学会・2024年度関東支部講演大会

https://www.jvss.jp/chapter/kanto/files/2024_kanto/index.html

[1] 藤枝俊宣.「バイオインテグレーションに向けた薄膜エレクトロニクスの開発」日本表面真空学会・2024年度関東支部講演大会 (2024.4.5., 東京).

2024.4.1

Members Updated!

Welcome Mahiro Suzuki to our group! Tatsuhiro has been promoted to be a Specially Appointed Assistant Professor!

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