French - Italian Workshop on "DNA Repair, Cancer and Neurodegeneration"
22 February 2018
Aula Magna, Dipartimento di Farmacia e Biotecnologie
Via della Beverara 123/1, Bologna
DNA replication/transcription conflicts are related to genome instability. Different causes could temporarily block or interfere with the progression of DNA replication or transcription machineries such as non-canonical secondary DNA structures, DNA-protein complexes, DNA damage and chromatin changes. The Workshop will mainly focus on emerging aspects of replication/transcription coordination mechanisms, DNA damage and repair pathways affecting genome stability in cancer and neurodegenerative diseases.
The workshop will take place in a highly stimulating scientific context and friendly atmosphere favoring an international exchange of knowledge, research experience and opinions concerning genome dynamics and disease mechanisms.
9:30 Welcome and Introduction to the Workshop
Chair: Tiziana Bonaldi, IEO, Milan, Italy
9:45 Philippe Pasero, Institute of Human Genetics, Montpellier, France
"SAMHD1 acts at stalled replication forks to prevent ssDNA-mediated induction of type I interferons"
10:30 Francesco Ghini, Postdoc, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy
"The acquisition of cell cycle-related competences characterizes the evolution of highly aggressive thyroid cancer"
10:45 Cinzia Cameli, PhD student, University of Bologna
"Copy number variation analysis in Autism Spectrum Disorders"
11:00 Simona Salimbeni, PhD student, University of Bologna and Toulouse Paul Sabatier University
"TDP1 role in Top1-mediated DNA cleavage repair and cell differentiation in human cells"
11:15 Coffee Break
Chair: Laura Baranello, Karolinska Institutet, Stockholm, Sweden
11:45 Vassilis Roukos, Institute of Molecular Biology gGmbH (IMB), Mainz, Germany
“Mechanistic insights in the formation of therapy-related oncogenic MLL translocations”
12:15 Olivier Sordet, CNRS Toulouse, France
"Topoisomerase I- and transcription-associated DNA double-strand breaks: potential links to human diseases"
12:45 Jessica Marinello, University of Bologna, Bologna, Italy
"Transient R loop induction by DNA topoisomerase inhibitors in cancer cells"
13:00-14:30 Lunch break
Chair: Olivier Sordet, CNRS Toulouse, France
14:30 Marco Muzi-Falconi, University of Milan, Milan, Italy
"Jumping the hurdle: protecting non replicating cells from the cytotoxic effect of complex DNA lesions"
15:00 Marco Foiani, IFOM and University of Milan, Milan, Italy
"ATR-mediated control of nuclear plasticity"
15:30 Beatrice Eymin, Institut Albert Bonniot, Grenoble, France
"The splicing factor SRSF2 is an early mediator of the DNA Damage Response in lung cancer cells"
16:00 Laura Baranello, Karolinska Institutet, Stockholm, Sweden
"Topoisomerase, supercoiling and the RNA polymerase: partners in regulating gene expression"
16:30 Giovanni Capranico, University of Bologna, Bologna, Italy
"R loop-mediated genome instability caused by G-quadruplex ligands"