French - Italian Workshop on "DNA Repair, Cancer and Neurodegeneration"

22 February 2018

Aula Magna, Dipartimento di Farmacia e Biotecnologie

Via della Beverara 123/1, Bologna

TOPIC

DNA replication/transcription conflicts are related to genome instability. Different causes could temporarily block or interfere with the progression of DNA replication or transcription machineries such as non-canonical secondary DNA structures, DNA-protein complexes, DNA damage and chromatin changes. The Workshop will mainly focus on emerging aspects of replication/transcription coordination mechanisms, DNA damage and repair pathways affecting genome stability in cancer and neurodegenerative diseases.

The workshop will take place in a highly stimulating scientific context and friendly atmosphere favoring an international exchange of knowledge, research experience and opinions concerning genome dynamics and disease mechanisms.


PROGRAM

9:30 Welcome and Introduction to the Workshop

SIBBM Lecture:

Chair: Tiziana Bonaldi, IEO, Milan, Italy

9:45 Philippe Pasero, Institute of Human Genetics, Montpellier, France

"SAMHD1 acts at stalled replication forks to prevent ssDNA-mediated induction of type I interferons"

10:30 Francesco Ghini, Postdoc, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

"The acquisition of cell cycle-related competences characterizes the evolution of highly aggressive thyroid cancer"

10:45 Cinzia Cameli, PhD student, University of Bologna

"Copy number variation analysis in Autism Spectrum Disorders"

11:00 Simona Salimbeni, PhD student, University of Bologna and Toulouse Paul Sabatier University

"TDP1 role in Top1-mediated DNA cleavage repair and cell differentiation in human cells"


11:15 Coffee Break

Chair: Laura Baranello, Karolinska Institutet, Stockholm, Sweden

11:45 Vassilis Roukos, Institute of Molecular Biology gGmbH (IMB), Mainz, Germany

“Mechanistic insights in the formation of therapy-related oncogenic MLL translocations”

12:15 Olivier Sordet, CNRS Toulouse, France

"Topoisomerase I- and transcription-associated DNA double-strand breaks: potential links to human diseases"

12:45 Jessica Marinello, University of Bologna, Bologna, Italy

"Transient R loop induction by DNA topoisomerase inhibitors in cancer cells"


13:00-14:30 Lunch break

Chair: Olivier Sordet, CNRS Toulouse, France

14:30 Marco Muzi-Falconi, University of Milan, Milan, Italy

"Jumping the hurdle: protecting non replicating cells from the cytotoxic effect of complex DNA lesions"

15:00 Marco Foiani, IFOM and University of Milan, Milan, Italy

"ATR-mediated control of nuclear plasticity"

15:30 Beatrice Eymin, Institut Albert Bonniot, Grenoble, France

"The splicing factor SRSF2 is an early mediator of the DNA Damage Response in lung cancer cells"

16:00 Laura Baranello, Karolinska Institutet, Stockholm, Sweden

"Topoisomerase, supercoiling and the RNA polymerase: partners in regulating gene expression"

16:30 Giovanni Capranico, University of Bologna, Bologna, Italy

"R loop-mediated genome instability caused by G-quadruplex ligands"


17:00 Conclusion

How to reach the event:

By bus:

  • Bus 30 stops in via della Beverara
  • Bus 11A and 11B stop in via Marco Polo (5 minutes walk)

Timetables and Bus Routes HERE


Sponsored by: