I majored in biomedical engineering in my college (UESTC). In the sophomore year, I went to "MOE Key Lab for Neuroinformation" leaded by Prof. Huafu Chen, where I found my interest in studying psychiatric disorders using in-vivo non-invasive imaging technology like Magnetic resonance imaging (MRI). After I got my bachelor's degree in UESTC, I could directly continue my study as a doctoral for excellent grades.

During these five years, I discovered some interesting findings about neural mechanism underlying schizophrenia based on MRI and functional MRI data. Patients' abnormalities were observed in both white matter and grey matter large-scale functional organization, as well as brain structure. My findings support two overarching hypotheses: the dysconnection hypothesis and the neurodevelopmental hypothesis of schizophrenia.

Now I'm focusing on discovering the genetic basis of brain structure and function abnormalities of schizoprenia, so I'm doing a visiting research with Dr. Sofie Louise Valk (https://cng-lab.github.io) at Max Planck Institute for Human Cognitive and Brain Sciences.

Publications in the last five years

(Preprint)

1. Yun-Shuang Fan, Yong Xu, Şeyma Bayrak, James M. Shine, Haoru Li, Liang Li, Siqi Yang, Yao Meng, Sofie Louise Valk, Huafu Chen. Macroscale Thalamic Functional Organization Disturbances And Underlying Core Cytoarchitecture In Early-Onset Schizophrenia. bioRxiv. 2022. doi: https://doi.org/10.1101/2022.05.11.489776

(# means co-first author )

2. Yun-Shuang Fan, Yong Xu, Qiang Li, Yuyan Chen, Xiaonan Guo, Siqi Yang, Jing Guo, Wei Sheng, Chong Wang, Qing Gao, Huafu Chen. Systematically mapping gray matter abnormal patterns in drug-naïve first-episode schizophrenia from childhood to adolescence. Cerebral Cortex. 2022. doi: 10.1093/cercor/bhac148.

3. Yun-Shuang Fan, Zehan Li, Xujun Duan, Jinming Xiao, Xiaonan Guo, Shaoqiang Han, Jing Guo, Siqi Yang, Jiao Li, Qian Cui, Wei Liao, Huafu Chen. Impaired interactions among white-matter functional networks in antipsychotic-naive first-episode schizophrenia. Human Brain Mapping. 2019;41(1):230-240.

4. Yun-Shuang Fan, Liang Li, Yue Peng, Haoru Li, Jing Guo, Meiling Li, Siqi Yang, Meng Yao, Jingping Zhao, Hesheng Liu, Wei Liao, Xiaonan Guo, Shaoqiang Han, Qian Cui, Xujun Duan, Yong Xu, Yan Zhang, Huafu Chen. Individual-specific functional connectome biomarkers predict schizophrenia positive symptoms during adolescent brain maturation. Human Brain Mapping. 2021;42(5):1475-1484.

5. Yun-Shuang Fan, Siqi Yang, Zehan Li, Jiao Li, Xiaonan Guo, Shaoqiang Han, Jing Guo, Xujun Duan, Qian Cui, Lian Du, Wei Liao, Huafu Chen. A temporal chronnectomic framework: Cigarette smoking preserved the prefrontal dysfunction in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2020;20(99):109860.

6. Yun-Shuang Fan^#, Haoru Li^#, Jing Guo^#, Yajing Pang, Liang Li, Maolin Hu, Meiling Li, Chong Wang, Wei Sheng, Hesheng Liu, Qing Gao, Xiaogang Chen, Xiaofen Zong, Huafu Chen. Tracking Positive and Negative Symptom Improvement in First-Episode Schizophrenia Treated with Risperidone Using Individual-Level Functional Connectivity. Brain Connectivity. doi: 10.1089/brain.2021.0061.

(co-authorship)

7. Wei Liao, Yun-Shuang Fan, Siqi Yang, Jiao Li, Xujun Duan, Qian Cui, Huafu Chen. Preservation effect: Cigarette smoking acts on the dynamic of influences among unifying neuropsychiatric triple networks in schizophrenia. Schizophrenia Bulletin. 2019; 45(6): 1242-1250.

8. Yuyan Chen, Qian Cui, Yun-Shuang Fan, Xiaonan Guo, Qin Tang, Wei Sheng, Ting Lei, Di Li, Fengmei Lu, Zongling He, Yang Yang, Shan Hu, Jiaxin Deng, Huafu Chen. Progressive brain structural alterations assessed via causal analysis in patients with generalized anxiety disorder. Neuropsychopharmacology. 2020; 45: 1-10.

9. Siqi Yang, Konrad Wagstyl, Yao Meng, Xiaopeng Zhao, Jiao Li, Peng Zhong, Bing Li, Yun-Shuang Fan, Huafu Chen, Wei Liao. Cortical patterning of morphometric similarity gradient reveals diverged hierarchical organization in sensory-motor cortices. Cell Reports. 2021; 36(8): 109582.

10. Mi Yang, Pu Yang, Yun-Shuang Fan, Jiao Li, Dezhong Yao, Wei Liao, Huafu Chen. Altered Structure and Intrinsic Functional Connectivity in Post-stroke Aphasia. Brain Topography. 2018;31(2):300-310.

11. Siqi Yang, Yao Meng, Jiao Li, Yun-Shuang Fan, Lian Du, Huafu Chen, Wei Liao. Temporal dynamic changes of intrinsic brain activity in schizophrenia with cigarette smoking. Schizophrenia Research. 2019; 210: 66-72.

12. Wei Liao, Siqi Yang, Jiao Li, Yun-Shuang Fan, Xujun Duan, Qian Cui, Huafu Chen. Nicotine in action: cigarette smoking modulated homotopic functional connectivity in schizophrenia. Brain Imaging and Behavior. 2019; 13(6):1612-1623.

13. Shaoqiang Han, Qian Cui, Xiaonan Guo, Yun-Shuang Fan, Jing Guo, Xiaofen Zong, Maolin Hu, Fengmei Lu, Xiaogang Chen, Huafu Chen. Disconnectivity between the raphe nucleus and subcortical dopamine-related regions contributes altered salience network in schizophrenia. Schizophrenia Research. 2020; 216: 382-388.

14. Siqi Yang, Yao Meng, Jiao Li, Bing Li, Yun-Shuang Fan, Huafu Chen, Wei Liao. The thalamic functional gradient and its relationship to structural basis and cognitive relevance. Neuroimage. 2020; 218: 116960.

15. Qiang Li, Sha Liu, Xiaohua Cao, Zexuan Li, Yun-Shuang Fan, Yanfang Wang, Jiaojian Wang, Yong Xu. Disassociated and concurrent structural and functional abnormalities in the drug-naïve first-episode early onset schizophrenia. Brain Imaging and Behavior. 2022. doi: 10.1007/s11682-021-00608-3.

16. Chong Wang, Hongmei Yan, Wei Huang, Jiyi Li, Yuting Wang, Yun-Shuang Fan, Wei Sheng, Tao Liu, Rong Li, Huafu Chen. Reconstructing Rapid Natural Vision with fMRI-Conditional Video Generative Adversarial Network. Cerebral Cortex. 2022. doi: 10.1093/cercor/bhab498.

17. Wei Sheng, Qian Cui, Kexing Jiang, Yuyan Chen, Qin Tang, Chong Wang, Yunshuang Fan, Jing Guo, Fengmei Lu, Zongling He, Huafu Chen. Individual variation in brain network topology is linked to course of illness in major depressive disorder. Cerebral Cortex. 2022. doi: 10.1093/cercor/bhac015.

18. Jing Guo, Hui Chen, Bharat B. Biswal, Xiaonan Guo, Huangbin Zhang, Limeng Dai, Yuhan Zhang, Liang Li, Yunshuang Fan, Shaoqiang Han, Juan Liu, Liu Feng, Qiannan Wang, Jian Wang, Chen Liu, Huafu Chen. Neurology. 2020; 95(22): 3036-3044.

19. Xiaonan Guo, Xujun Duan, Heng Chen, Changchun He, Jinming Xiao, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Huafu Chen. Altered inter- and intrahemispheric functional connectivity dynamics in autistic children. Human Brain Mapping. 2020; 41(2): 419-428.

20. Shaoqiang Han, Qian Cui, Xiao Wang, Liang Li, Di Li, Zongling He, Xiaonan Guo, Yun-Shuang Fan, Jing Guo, Wei Sheng, Fengmei Lu, Huafu Chen. Resting state functional network switching rate is differently altered in bipolar disorder and major depressive disorder. Human Brain Mapping. 2020; 41(12): 3295-3304.

21. Shaoqiang Han, Qian Cui, Xiao Wang, Yuyan Chen, Di Li, Liang Li, Xiaonan Guo, Yun-Shuang Fan, Jing Guo, Wei Sheng, Fengmei Lu, Zongling He, Huafu Chen. The anhedonia is differently modulated by structural covariance network of NAc in bipolar disorder and major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2020; 20(99): 109865.

22. Siqi Yang, Zhiqiang Zhang, Huafu Chen, Yao Meng, Jiao Li, Zehan Li, Qiang Xu, Qirui Zhang, Yun-Shuang Fan, Guangming Lu, Wei Liao. Temporal variability profiling of the default mode across epilepsy subtypes. Epilepsia. 2021;62(1):61-73.

23. Shaoqiang Han, Xiao Wang, Zongling He, Wei Sheng, Qijun Zou, Liang Li, Yang Yang, Xiaonan Guo, Yun-Shuang Fan, Jing Guo, FengMei Lu, Qian Cui, Huafu Chen. Decreased static and increased dynamic global signal topography in major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019; 94:109665.

24. Jing Guo, Zhouyu Jiang, Bharat B Biswal, Bo Zhou, Dongjing Xie, Qing Gao, Wei Sheng, Hui Chen, Yuhan Zhang, Yunshuang Fan, Jian Wang, Chen Liu, Huafu Chen. Hypothalamic Atrophy, Expanded CAG Repeat, and Low Body Mass Index in Spinocerebellar Ataxia Type 3. Movement Disorder. 2022. doi: 10.1002/mds.29029.

25. Xiaonan Guo, Xujun Duan, John Suckling, Jia Wang, Xiaodong Kang, Heng Chen, Bharat B Biswal, Jing Cao, Changchun He, Jinming Xiao, Xinyue Huang, Runshi Wang, Shaoqiang Han, Yun-Shuang Fan, Jing Guo, Jingping Zhao, Lijie Wu, Huafu Chen. Mapping Progressive Gray Matter Alterations in Early Childhood Autistic Brain. Cerebral Cortex. 2020; 31(3):1500-1510.