To reduce under 3 morbimortality 6 interconnected work packages (WPs) were defined:
Inventory of available biobanks and databases, e-portal and collaborations modalities.
Long-lasting indicators of health, including the detection of emerging dangerous bacterial strains, and healthcare practices of parents and healthcare professionals -HPs- and study of their determinants.
Clinical trials catalyser, risk stratification modelling, biomarker discovery.
Health digital learning tools and trials to modify knowledge, attitudes, and practices of parents, especially disadvantaged parents, and HPs.
e-platform, editorial responsibilities, partnership with social influencers
Coordinated responses to calls for projects and an early carrier accelerator program
WP 1: FHU CHILD partners manage or have access to numerous sources of data and biocollections. A detailed inventory of these available resources avoid duplicating efforts and optimize accessibility and internal and external collaborations.
In WP 2, we use advanced epidemiological methods to identify the determinants of child health status, including carriage of or infection by emerging, resistant and/or virulent strains of major pathogens, and knowledge, attitudes and practices (KAPs) of parents and healthcare professionals (HPs) regarding young child health, with special attention to identifying the modifiable mediating factors of social inequalities in health.
In WP 3, we conduct large clinical trials notably on new vaccines and treatments of bronchiolitis, develop risk stratification models and identify new biomarkers for the diagnosis and prognosis of abusive brain injury and early detection of bacterial infection and decipher new causes of SIDS.
In WP 4, we develop health digital learning tools to modify parental and HP KAPs at the national scale and evaluate these tools with educational trials, with a focus on disadvantaged populations.
In WP 5, we insure knowledge dissemination among parents and HPs. Scientific dissemination relies on press releases, social networks, and on new approaches offered by Frontiers in Pediatrics, the top open-access pediatric journal, partner of the FHU. Dissemination among parents is implemented in trials by using the approach described in WP 4. It will be extended by a smartphone application and a website. In WP 5, we also create relationships with social influencers who may have an impact among young parents and HPs.
WP 6 includes an inclusive policy to submit applications to PHRC, RHU, ANR and European calls (task 1), an early carrier accelerator program (task 2) with structured help to obtain PhD grants including CIFRE and post-doctoral positions, short internships outside the hosting lab during the PhD and a best poster award at the annual scientific FHU CHILD meeting (task 3), and an annual starting grant for federative projects. A general kick-off meeting and specific ones (complex data, biomarkers, implementation strategies) are held in the two first semesters of the FHU CHILD.