Research

The Functional Genomics and Gene Editing Laboratory (FGGE Lab) investigates how genetic variation alters gene and cellular function. We study genetic changes across a broad spectrum, ranging from single-nucleotide variants and small insertions or deletions to large structural alterations.

Our central goal is to connect genotype and phenotype by determining which genetic variants are functionally important, how they disrupt biological processes, and how they contribute to human disease. To achieve this, we integrate genome editing, high-throughput functional screening, molecular and cellular assays, and computational genomics.

In particular, we develop scalable experimental platforms to evaluate variants of uncertain significance, identify disease-associated genes and regulatory elements, and uncover the molecular mechanisms underlying genetic disorders. By combining functional genomics with precise genome engineering, we aim to transform genomic data into biologically and clinically meaningful knowledge.

Ultimately, our research seeks to improve genetic variant interpretation, advance molecular diagnostics, identify potential therapeutic targets, and contribute to the development of precision medicine.