2024
Structural basis of pH-dependent activation in a CLC transporter. Fortea, E., Lee, S., Chadda, R. Argyros, Y., Sandal, P., Mahoney-Kruszka, R., Ciftci, D., Falzone, M.E., Huysmans, G., Robertson, J.L., Boudker, O., Accardi, A. Nat Struct Mol Biol (2024). doi: 10.1038/s41594-023-01210-5
2023
The mechanism of Gaq regulation of PLCβ3-catalyzed PIP2 hydrolysis. Falzone, M.E. and MacKinnon, R. Proc Natl Acad Sci USA. 2023,120(48): e2315011120. doi: 10.1073/pnas.2315011120. PMID: 37991948.
Gβγ Activates PIP2 Hydrolysis by Recruiting and Orienting PLCβ on the Membrane Surface. Falzone, M.E. and MacKinnon, R. Proc Natl Acad Sci USA. 2023,120(20): e2301121120. doi: 10.1073/pnas.2301121120. PMID: 37172014.
2022
TMEM16 scramblases thin the membrane to enable lipid scrambling. Falzone, M.E*., Feng, Z*., Alvarenga, O.E., Pan, Y., Lee, B., Cheng, X., Fortea, E., Scheuring, S., Accardi, A. Nature Communications. 2022,13(1):2604. doi: 10.1038/s41467-022-30300-z, PMID: 35562175 *denotes co-first author.
2020
Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Khelashvili, G., Cheng, X., Falzone, M. E., Doktorova, M., Accardi, A., Weinstein, H. Journal of Computational Chemistry. 2020,41(6):538–551. doi:10.1002/jcc.26105, PMID: 31750558.
Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays. Falzone, M.E., Accardi, A. In: Perez C., Maier T. (eds) Expression, Purification, and Structural Biology of Membrane Proteins. Methods in Molecular Biology, 2020,2127. Humana, New York, NY
2019
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16. Khelashvili, G*., Falzone, M. E*., Cheng, X., Lee, B. C., Accardi, A., Weinstein, H. Nature Communications. 2019,10(1):4972. doi: 10.1038/s41467-019-12865-4, PMID: 31672969 *denotes co-first author.
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Bushell, S. R*., Pike, A. C. W*., Falzone, M. E*., Rorsman, N. J. G., Ta, C. M., Corey, R. A., Newport, T. D., Shintre, C. A., Tessitore, A., Chu, A., Wang, Q., Shrestha, L., Mukhopadhyay, S. M. M., Love, J., Burgess-Brown, N. A., Sitsapesan, R., Sttansfeld, P. J., Huiskonen, J. T., Tammaro, P., Accardi, A., Carpenter, E. P. Nature Communications. 2019,10(1):3956. doi: 10.1038/s41467-019-11753-1, PMID: 31477691 *denotes co-first author.
Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase. Falzone, M. E., Rheinberger, J., Lee, B. C., Peyear, T., Sasset, L., Raczkowski, A., Eng, E., Di Lorenzo, A., Anderson, O. S., Nimigean, C., Accardi, A. Elife. 2019,8:e43229, doi: 10.7554/eLife.43229, PMID: 30648972.
2018
Known structures and unknown mechanisms of TMEM16 scramblases and channels. Falzone, M. E., Malvezzi, M., Lee, B.C., Accardi, A. The Journal of General Physiology. 2018,150(7):933-947. doi: 10.1085/jgp.201711957, PMID: 29915161.
Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases. Malvezzi, M., Andra, K. K., Pandey, K., Lee, B.C., Falzone, M. E., Brown, A., Accardi, A. Proc Natl Acad Sci USA, 2018,115(30):E7033-E4042, doi: 10.1073/pnas.1806721115, PMID: 29925604.
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Lee, B. C., Khelashvili, G., Falzone, M., Menon, A. K., Weinstein, H., Accardi, A. Nature Communications. 2018,9(1):3251 doi: 10.1038/s41467-018-05724-1, PMID: 30108217.
2017
Nutritional control of antibiotic production by Streptomyces platensis MA7327: Importance of l-aspartic acid. Falzone, M., Crespo, E., Jones, K., Khan, G., Korn, V. L., Patel, A., Demain, A. L. Journal of Antibiotics. 2017,70(7):828-831, doi: 10.1038/ja.2017.49, PMID: 28465627.
2013
Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis. Falzone M., Martens E., Tynan H., Maggio C., Golden S., Nayda V., Crespo E., Inamine G., Gelber M., Lemence R., Chiappini N., Friedman E., Shen B., Gullo V., Demain AL. Appl Microbiol Biotechnol. 2013,97(21):9535-9, doi: 10.1007/s00253-013-5201-6, PMID: 24022611.
2012
Development of a semi-defined medium supporting production of platensimycin and platencin by Streptomyces platensis. Aluotto S., Tynan H., Maggio C., Falzone M., Mukherjee A, Gullo V., Demain AL. Journal of Antibiotics. 2012,66(2):51-54, doi: 10.1038/ja.2012.97, PMID: 23188381.