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角膜振動特徵於青光眼之輔助診斷
As glaucoma becomes a major visual health issue in an aging society, more accurate early diagnosis has become a crucial research topic. This study aims to investigate the impact of glaucoma on corneal stress performance and the correlation between corneal parameters and glaucoma diagnosis, to improve the accuracy and efficiency of early diagnosis. The study utilized corneal imaging data captured by the Corvis® ST tonometer, collected from glaucoma patients and normal subjects from multiple ophthalmology clinics.
by 陳小汶
水晶體與人工水晶體之力學分析
This study investigates the mechanical properties of the lens during accommodation, developing an experimental method to simulate the biomechanical characteristics of the eye and exploring the role of zonules as a force transmission medium. The experimental design includes tensile tests on porcine lenses to observe the adhesion between the zonules and the lens, and analyzes the distribution of isochromatic lines under photoelastic stress. However, no significant isochromatic lines were observed under a plane-polarized optical system, likely due to a uniform stress distribution within the lens or insufficient refractive index differences to produce significant birefringence effects. To further investigate, we attempted to alter the direction and position of the applied force and introduced a circularly polarized optical system to eliminate isoclinic line interference. Even with these adjustments, the porcine lens did not display observable isochromatic lines, suggesting that the stress distribution or material properties of the lens might prevent sufficient phase differences in light within the lens to form visible isochromatic lines.
by 蔡小伸
中醫脈診 腎衰竭
Digital sphygmomanometers have been used for more than 40 years in Western medicine for accurately measuring systolic and diastolic blood pressures, which are vital signs observed for the diagnosis of different diseases. Similarly, traditional Chinese medicine (TCM) has been using wrist pulse diagnosis for thousands of years. Some studies have combined digital wrist pulse signals and the diagnosis method of TCM to quantify pulse waves and identify diseases. However, the effectiveness of this approach is limited because of scattered methods and complex pathological features. Moreover, the literature on TCM does not provide quantitative data or objective indicators.
by 施阿貓
Swimming Biomechanics
Because the absence of measurement devices recording a swimmer's speed from the starting block to the wall touch with minimal interference, hinders the standardization of evaluating forward speed, stroke phase identification, and propulsive force. The study aims to collect swimmers’ motion utilizing streamlined and high-resolution equipment, allowing for a comprehensive analysis of swimming patterns. Moreover, the calculation of instantaneous forward speed and the comparison of swimming indicators provide insights into the mechanical interactions in water.
by 陳小慈 (游泳姿態分析)
AI analysis in Keratoconus
Keratoconus is the most common form of primary corneal ectasia, characterized by localized thinning of the cornea. It leads to protrusion and irregular astigmatism, affecting vision. Traditional diagnostic instruments rely on static observations of corneal features, while dynamic observation with an air-puff tonometer is currently the advanced biomechanical method. Air-puff deforms the cornea by blowing air, and it could be the method to detect keratoconus at an early stage. In our study, we collected data from air-puff tonometry, including corneal data from patients with astigmatism, keratoconus, and normal individuals.
by 廖小圻 (圓錐角膜)
Pure Tensional Cell Testing
We developed a pneumatically controlled pure tension stretching system, which the strain and frequency were regulated, and the surface-treated polyacrylamide hydrogel was used as the cell culture substrate. The results exhibited that compared to the static cultivation, periodic stretching strain had a positive effect on the differentiation and proliferation of corneal keratocytes. Moreover, we examined the opacification of the cornea after wound healing. We created tiny wounds of human keratocytes and subjected to a dynamic environment with uniform strain, then recorded the healing process in real-time at the same location.
by 林小辰 (細胞拉伸)
by 林小辰 (細胞拉伸)
Cell Tensional Testing
Dynamic cell cultures simulate the in vivo cell environment for a regular loading system with curtain strains. However, it is difficult to obtain strains that are suitable for cells without conducting multiple trials. This study develops a device that increases the strain gradient by changing the tensile section, in order to determine the effect of various cyclic strains on cultured human keratinocytes (HK) cells.
by 戴小軒 (細胞拉伸)
Cell Modeling
Our cell migration model has been constructed from Odde’s cell migration model and from Keren’s membrane force theory to analyze the mechanical interaction between multiple cells. To complete this model, we added a timer to the original model as a basis for controlling cell itself behavior. Accordingly to other researches, we developed functions such as growth, cytokinesis, and sensing the size of the surrounding space to complete cell migration performance. The simulation results showed that the new cells divided have an effect on the balance position among others.
by 呂小頤 (細胞爬行與分裂模擬)
Cell Migration
Artificial corneas have been widely adopted to alleviate the lack of donor tissues, and using tissue engineering with autologous cells can overcome issue rejection in clinics. To solve the uncertainty of cell culture on the development artificial materials, we developed and designed a cell migration model after we investigated recently cell model developments. Most theories developed for cell model focused on the influence of substrate stiffness related to cell behaviors, and thus they simulated a single cell at a time and studied its details. Our model was modified from Odde’s cell migration model and applied Gillespie’s stochastic algorithm and Keren’s membrane forces theory, so cellular interactions and environmental cues could be considered and analyzed in many cells.
by 張小祐 (程式設計與力學分析)
Keratoconus AI Detection
The symptoms of keratoconus are not easily detected and diagnosed in the early stage, so there is an increasing demand in a standard for early detection and diagnosis. The purpose of study is to develop a method to find the characteristics of keratoconus through mathematical methods and machine learning. Finally use this method to predict and analyze for improve early diagnosis and assist clinical diagnosis rate.Therefore, we find the parameters by decomposition Legendre of the corneal deformation figure to correlate with the parameters of corneal photography, and seek relevant classification basis. The characteristic parameters of the keratoconus were extracted from the corneal photography, and we classified only the upper or lower keratoconus and the upper and lower keratoconus and the normal cornea were according to the classification.
by 王小曆 (AI 分析與影像處理)
Corneal potoelasticity
Corneal potoelasticity
The detection of the cornea is mainly through the determination of the appearance to know the state of the cornea, but we can’t understand the actual force on the cornea. The only way to realize the force of the cornea in a non-destructive way is to use photoelasticy. To achieve the purpose of non-destructive detection of corneal force, the stress-optic coefficient of the cornea is the key parameter for quantitative measurement.
by 程小謙 (影像分析與光學實驗)
Corneal vibration
Corneal vibration
Cornea is a transparent material locating in front of the eye with smooth, tough and elastic surface. It covers the iris, pupil and anterior chamber and accounts for most of the eye's refractive power. The aim of this study is to analyze cornea’s irregular vibrationduring air-puff time in the measurement of intraocular pressure. The differences in corneal vibration result from the geometric differences in cornea which would indicate to corneal pathologies.
by 賴小儒 (影像分析與程式設計)
Rubbing eye
Rubbing eye
Cornea always endures the external forces by blinking eyes, rubbing eyes and external strike in ordinary life. If rubbing eyes is a habitual behavior, it will cause the huge damage to the eyes. After a long period of time, it may lead to keratitis, keratoconus and corneal tissue lesions. Even more seriously, it will become visually impaired and blind. In order to quantize the damage of rubbing eyes specifically, the research uses the porcine eyes to simulate the human eyes. To study the eyes deformation, bearing external force and the change of IOP by controlling the rubbing eyes’ depth.
by 陳小廷 (力學實驗與影像處理)
Eye orbit effect and acoustic tonometer
Eye orbit effect and acoustic tonometer
The eye orbit has mechanical and acoustic characteristics that determine resonant frequencies and amplify acoustic signals in certain frequency ranges. These characteristics also interfere with the acoustic amplitudes and frequencies of eyeball when measured with an acoustic tonometer. A model in which a porcine eyeball was embedded in ultrasonic conductive gel in the orbit of a model skull was used to simulate an in vivo environment, and the acoustic responses of eyeballs were detected. The triggering source was a low‐power acoustic speaker contacting the occipital bone, and the detector was a high‐resolution microphone with a dish detecting the acoustic signals without contacting the cornea. Dozens of ex vivo porcine eyeballs were tested at various intraocular pressure levels to detect their resonant frequencies and acoustic amplitudes in their power spectra. We confirmed that the eyeballs’ resonant frequencies were proportional to intraocular pressure, but interference from orbit effects decreased the amplitudes in these resonant frequency ranges. However, we observed that the frequency amplitudes of eyeballs were correlated with intraocular pressure in other frequency ranges. We investigated eye orbit effects and demonstrated how they interfere with the eyeball’s resonant frequencies and frequency amplitudes. These results are useful for developing advanced acoustic tonometer.
by 武小傑 (豬眼力學實驗)
Application to Bernoulli model for analyzing intraocular pressure
Whether the intraocular pressure(IOP) in the anterior chamber measured by insufflation equal to the vitreous is a question for ophthalmologists. The IOP measurement is currently measuring the IOP of the anterior chamber, since we cannot directly measure the IOP of the vitreous. However, the friction of the aqueous channel of normal participants and glaucoma patients is not the same, and the aqueous humor in the posterior chamber of patients with angle-close glaucoma (ACG) is not easy to flow to the anterior chamber. On the other hand, during the air blow measurement, the aqueous humor is not easily flow to the posterior chamber, but it accumulates more in the anterior chamber. That lets the IOP in the anterior chamber to be overestimated. In this paper, we used Bernoulli's principle to construct the IOP model, and obtained analytical solutions in the form of a series solution.
by 宋小欣 (眼內液體壓力平衡)
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