Publications
Dr. Kwang Suk Ko studied at Korea University for Bachelor and Master degrees for animal nutrition major, especially toxicity of nitrate on thyroid metabolism. After these, he was accepted to the Graduate Group in Nutritional Biology at the University of California Davis and revealed the basic biochemical mechanisms of taurine deficiency in dogs, which causes dilated cardiomyopathy. With the interest in sulfur-containing amino acid and its metabolites such as taurine and S-adenosylmethionine, Dr. Ko pursued the molecular mechanisms of developing liver cancer at Keck School of Medicine, University of Southern California as a post-doctoral research associate. Dr Ko is now serving his duties at Ewha Womans University.
His current research interests are 1) regulation of cancer development by prohibitin1 (Phb1) gene in liver, 2) S-adenosylmethionine (SAMe) and its synthesizing genes, methionine adenosyltransferases (MAT) as liver cancer regulators, 3) glutathione metabolism in liver disease as an antioxidant and xenotoxic sequester, and 4) genetic manipulation to develop optimal liver cancer animal models.
Journal
Peer reviewed:
1. Lee SH, Kim KD, Ko Kwang Suk, Son YS. Retinoic acid levels and function of porcine thyroid cells in vitro. Journal of Animal Science & Technology(Kor) 2000;42(2):165-72
2. Backus RC, Ko Kwang Suk, Fascetti AJ, Kittleson MD, MacDonald KA, Maggs DJ, Berg JR, Rogers QR. Low plasma taurine concentration in Newfoundland dogs is associated with low plasma methionine and cyst(e)ine concentrations and low taurine synthesis. Journal of Nutrition 2006 Oct;136(10):2525-33 (PMID:16988121)
3. Ko Kwang Suk, Torres CL, Fascetti AJ, Stipanuk MH, Hirschberger L, Rogers QR. Copper deficiency does not lead to taurine deficiency in rat. Journal of Nutrition 2006 Oct;136(10):2502-5 (PMID:16988117)
4. Ko Kwang Suk, Backus RC, Berg JR, Lame MW, Rogers QR. Differences in taurine synthesis rate among dogs relate to differences in their maintenance energy requirement. Journal of Nutrition 2007 May;137(5):1171-5 (PMID:17449577)
5. Ko Kwang Suk, Yang H, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, Luka Z, Mato JM, Lu SC. Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab Investigation 2008 Oct;88(10):1121-9 (PMID:18695670)
6. Yang H, Li TWH, Ko Kwang Suk, Xia M, Lu SC. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mice and human hepatocytes. Hepatology 2009 Mar;49(3):860-70 (PMID:19086036)
7. Yang H, Ramani K, Xia M, Oh P, Li TWH, Ko Kwang Suk, Lu SC. Dysregulation of glutathione synthesis during cholestasis: Molecular mechanisms and therapeutic implications. Hepatology 2009 Jun;49(6):1182-91 (PMID:19399914)
8. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko Kwang Suk, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in rat model. Hepatology 2009 Aug;50(2):462-71 (PMID:19444874)
9. Yang H, Ko Kwang Suk, Xia M, Li TWH, Oh P, Li J, Lu SC. Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice. Hepatology 2010 Apr;51(4):1290-301 (PMID:20146260)
10. Li J, Ramani K, Sun Z, Zee C, Grant EG, Yang H, Xia M, Oh P, Ko Kwang Suk, Mato JM, Lu SC. Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. Am J. Pathol. 2010 May;176(5):2456-66 (PMID:20363925)
11. Tomasi ML, Ramani K, Lopitz-Otsoa F, Rodriguez MS, Li TWH, Ko Kwang Suk, Yang H, Bardag-Gorce F, Iglesia-Ara A, Feo F, Pascale MR, Mato JM, Lu SC. S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human Hepatocytes. Hepatology 2010 Jun;51(6):2152-61 (PMID:20196119)
12. Ko Kwang Suk, Tomasi ML, Igesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TWH, Yang H, Martinez-Chantar ML, Mato JM, Lu SC. Liver-Specific deletion of prohibitin1 results in spontaneous liver injury, fibrosis and hepatocellular carcinoma in mice. Hepatology 2010 Dec;52(6):2096-2108 (PMID:20890892), Selected for cover figure.
13. Yang H, Li TWH, Peng J, Tang X, Ko Kwang Suk, Xia M, Aller MA. A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. Gastroenterology 2011 Jul;141(1):378-388.e4 (PMID:214405490), Selected for editorials
14. Ko Kwang Suk, Peng H, Tang H, Cho ME, Peng J, Aller M, Yang H. Recent advances of miRNA involvement in hepatocellular carcinoma and cholangiocarcinoma. Open Journal of Internal Medicine 2012;2:135-162
15. Lamani K, Tomasi ML, Yang H, Ko Kwang Suk, Lu SC. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. Journal of Biological Chemistry 2012 Oct;287(43):36341-55 (PMID: 22942279)
16. 고광석. 황함유 아미노산의 간기능 보호작용(Hepatoprotectve functions of sulfur containing amino acids: Hepatocellular carcinoma prevention) 한국식품과학회지(Korean J Food Sci Technol) 2012 Dec;44(6):653-657
17. Yang H, Cho ME, Li TWH, Peng H, Ko Kwang Suk, Mato JM, Lu SC. MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. Journal of Clinical Investigation 2013 Jan;123(1):285-298 (PMID: 23241961)
18. Ko Kwang Suk, Peng J, Yang H. Animal models of cholangiocarcinoma. Current Opinion in Gastroenterology 2013 May;29(3):312-318 (PMID: 23434850)
19. Peng J, Yue C, Qiu K, Chen J, Aller M, Ko Kwang Suk, Yang H. Protective effects of guava pulp on cholestatic liver injury. ISRN Hepatology 2013, Article ID 601071, 11pages (http://www.hindawi.com/journals/isrn/2013/601071/)
20. Tomasi ML, Ryoo M, Yang H, Ara AI, Ko Kwang Suk, Lu SC. Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice. Free Radical Biology & Medicine 2014 Mar;68:148-58 (PMID: 24296246)
21. 이상훈, 송영선, 이서연, 김소영, 고광석. 급성 알코올 간독성을 유발한 생쥐에 있어서 으름 열매 추출물의 간 기능 보호효과 (Protective effects of Akebia quinata fruit extract on acute alcohol-induced hepatotoxicity in mice) 한국식품과학회지(Korean J Food Sci Technol) 2014 Oct;46(5) 622-629
22. Ting Liu, Yu Zhou, Ko Kwang Suk, H Yang. Interactions between Myc and Mediators of Inflammation in Chronic Liver Disease. Mediators of Inflammation 2014, Article ID 276850, 12pages (http://www.hindawi.com/journals/mi/aa/276850/cta/)
23. 곽정은, 이서연, 이상훈, 고광석. 대중매체 식품영양정보에 대한 성인 여성의 요구도 조사 (A survey for needs and preference of food and nutrition information on mass media for Korean female adults) 대한지역사회영양학회지 (Journal of Community Nutrition) 2014 Dec;19(6) 550-557
24. 정수한, 이상훈, 고광석. 다양한 마늘 추출물이 HepG2 세포에서 콜레스테롤 합성에 미치는 효과 (Effects of various garlic extracts on cholesterol synthesis in HepG2 cells) 한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition) 2015 44(12): 1771-1778
25. 정수한, 이상훈, 고광석. Oleanolic acid와 hederagenin이 급성 알코올성 간독성에 미치는 효과 (Effects of oleanolic acid and hederagenin on acute alcohol-induced hepatotoxicity in mice) 한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition) 2016 Mar:45(3) 307-312
26. Jung SH, Lee SH, Song YS, Lee SY, Kim SY, Ko Kwang Suk. Effects of beverage containing fermented Akebia quinata extracts on alcohol hangover. Preventive Nutrition and Food Science 2016 Mar:21(1): 1-9
27. Ko Kwang Suk, Fascetti AJ. Dietary beet pulp decreases taurine status in dogs fed a low protein diet. Journal of Animal Science and Technology 2016 58:29 (open access journal, published Aug 2nd 2016)
28. Lee SY and Ko Kwang Suk. Effects of S-adenosylmethionine and its combinations with taurine and/or betaine on glutathione homeostasis in ethanol-induced acute hepatotoxicity models. Journal of Cancer Prevention 2016 Sep 21(3): 164-172
29. Lee SY and Ko Kwang Suk. Protective effects of S-adenosylmethionine and its combinations with taurine and/or betaine against lipopolysaccharide or polyinosinic-polycytidylic acid-induced hepatotoxicity. Journal of Cancer Prevention 2016 Sep 21(3): 152-163
30. Lee SH, Kim JM, Ryu YC and Ko Kwang Suk. Effects of morphological characteristics of muscle fibers on porcine growth performance and pork quality. Korean Journal for Food Science of Animal Resources 2016 Oct 36(5): 583-593
31. 이윤지, 고광석. 유산균 배양액 추출액의 항병원성 효과 및 냉장저장 육제품의 품질에 미치는 효과 (Effects of extract of lactic acid bacteria culture media on quality characteristics of pork loin and antimicrobial activity against pathogenic bacteria during cold storage) 한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition) 2016 Oct 45(10): 1476-1480
32. 이혜림, 홍은아, 고광석, 이경은. 어머니의 식습관, 요리습관 및 운동습관과 학령기 후기 아동의 Broca 체질량지수와의 상관간계 연구 (Relationship between Broca Index of the late school-aged children and their mothers’ eating, cooking and exercise habit) 한국식품영양과학회지(Journal of the Korean Society of Food Science and Nutrition) 2016 Oct 45(10): 1488-1496
33. Ramani K, Mavila N, Ko Kwang Suk, Mato JM, Lu SC. Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes. Journal of Biological Chemistry 2016 Nov 291(46): 24148-24159
34. Jung S, Kim MH, Park JH, Jeong Y, Ko Kwang Suk. Cellular antioxidant and anti-inflammatory effects of coffee extracts with different roasting levels. Journal of Medicinal Food 2017 20(6): 626-635
35. Lee SH, Song YS, Ko Kwang Suk. Anti-oxidative and anti-inflammation activity of Akebia quinata extracts in acute alcohol-induced hepatotoxicity in vitro. Journal of Medicinal Food 2017 20(9): 912-922
36. Lee YJ. Ko Kwang Suk etc. Clustering of health risk behaviors for chronic diseases in Korean adults. Korean Journal of Health Education and Promotion 207 34(9): 21-31
37. Choi S, Jung S, Ko Kwang Suk. Effects of coffee extracts with different roasting degrees on antioxidant and anti-inflammatory system in mice. Nutrient 2018, 10, 363
38. 허기은, 박재희, 김유리, 김혜경, 이민수, 김정현, 고광석. 한국인 칼슘 섭취 실태와 관련 요인: 제6기(2013~2015) 국민건강영양조사 자료를 이용하여 (Analysis of Consumption Status of Calcium with Related Factors in a Korean Population: Based on Data from 2013~2015 Korean National Health and Nutritional Examination Survey (KNHANES)), 한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition) 2018 Mar 47(3): 328-336
39. 김경주, 송지현, 김혜경, 고광석, 김유리, 이민수. 개인맞춤형 건강진단을 위한 건강데이터 수집 모바일 플랫폼의 설계와 구현 (Design and Implementation of a Health Data Collection Mobile Platform for Personalized Health Diagnosis), 데이터베이스연구 2018 34(1): 59-68
40. 김지예, 강지완, 김하림, 고주연, 김혜경, 김유리, 고광석, 이민수. 대사증후군 예방을 위한 모바일 헬스 애플리케이션의 개인맞춤형 콘텐츠 개발 (Development of tailored contents of mobile health application to prevent the metabolic syndrome), 보건교육증진학회지 2018 35(3): 25-40
41 Hoe G, Ko Kwang Suk. Long-term feeding of soy protein attenuates choline deficient-induced adverse effects in wild type mice and prohibitin 1 deficient mice response more sensitively. Preventive Nutrition and Food Science, 2019, 24.1: 32.
42. 강권수, 이규원, 정수한, 강대진, 고광석. 국내 건강기능식품의 복수 섭취에 따른 이상사례 신고 내용 분석 및 관리 방안 (Analysis and Management of Abnormal Cases by Multiple Intake of Korean Health Functional Foods), 한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition) 2020 49(5): 511-520
43. Jung S, Park J, Ko Kwang Suk. Lipopolysaccharide-induced innate immune responses are exacerbated by Prohibitin 1 deficiency and mitigated by S-adenosylmethionine in murine macrophages. PLoS ONE 2020 15(11): e0241224
44. Kim H, Seo H, Park Y, Lee H, Lee S, Ko Kwang Suk. Development of a human estrogen receptor dimerization assay for the estrogenic endocrine-disturbing chemicals using bioluminescence resonance energy transfer. International Journal of Environmental Research and Public Health 2021 18(16): ijerph18168875
45. Lee K, Yu H, Shouse S, Kong B, Lee J, Lee S, Kwang Suk Ko. RNA-sequence reveals different gene expression in liver-specific prohibitin 1 knock-out mice. Frontiers in Physiology 2021 12:717911
46. Kim J, Dorgan JF, Kim H, Kwon O, Kim Y, Kim Y, Ko Kwang Suk, Park YJ, Park H, Jung S. Association between Use of Nutrition Label and Risk of Chronic Kidney Disease: The Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2019. Nutrients 2022 14, 1731. Nu14091731
47. Wang S, Jung S, Kwang Suk Ko. Effects of Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells. Nutrients 2022 10.3990 nu14153050
48. Yanran W, Jung S, Kwang Suk Ko. Saturated Fatty Acid-Induced Impairment of Hepatic Lipid Metabolism is Worsened by Prohibitin 1 Deficiency in Hepatocytes. Journal of Medicinal Food 2022 25(8), 845-852
49. Cho E, Jung S, Kim J, Kwang Suk Ko. The Relationship between Prohibitin 1 Expression, Hepatotoxicity Induced by Acetaminophen, and Heaptoprotection by S-Adenosylmethionine in AML12 Cells. Journal of Microbiology and Biotechnology 2022 32(11), 1477-1453
50. Han BK, Yoon H, Kim KH, Shin E, Kwang Suk Ko, Lee H, Kim YJ. Inhibitory Effects of Wheat Extract on RANKL-Induced Osteoclast Differentiation via Suppressing MAPK and NFATc1 Signaling Pathways. Journal of Medicinal Food 2023 26(7), 480-488
51. Kim HM, Kim Y, Kim Y, Kim YJ, Kwang Suk Ko. Organoid Estabolishment of Long-Term Culture Using Primary Mouse Hepatocytes and Evaluation of Liver Function. Preventive Nutrition and Food Science 2023 28(3),360
52. Jung S, Yu H, Kwang Suk Ko. Novel Effects of Prohibitin 1 Expression Level on Cholesterol and Lipid Homeostasis. The Journal of Nutritional Biochemistry 2024, 109561
BOOKS
GRANTS
Awarded: as a main researcher and project writer
2023 Ministry of Food and Drug safety (식품의약품안전처)
(￦2,760 million / 2023 April 1st ~ 2027 Dec 31th)
Title: Development and Application of the Safety Prediction/Management System for Overlapped/Combined Intake of Health Function Foods
(기능성 원료 등 중복/병용 섭취 안전성 예측 기술 개발·적용)
Ministry of Food and Drug safety
2023 National Research Foundation Funds (한국연구재단)
(￦591 million / 2023 March 1st ~ 2027 Feb 28th)
Title: Development of prediction model for liver disease susceptibility based on the expression level of Prohibitin 1 for human application and identification of hepato-protective mechanisms of sulfur-containing amino acids
(Prohibitin 1 발현 수준에 따른 간 질환 민감성 예측 인체적용 기반 연구 및 황함유아미노산의 간 보호 기전 규명)
2023 Ministry of Food and Drug safety (식품의약품안전처)
(￦44 million / 2023 Feb 23rd ~ 2023 Nov 30th)
Title: Convergence health functional food safety management support and institutionalization
(융복합 건강기능식품안전관리 지원 및 제도화 사업)
Ministry of Food and Drug safety
2023 Ministry of Food and Drug safety (식품의약품안전처)
(￦55 million / 2023 Feb 1st ~ 2024 Nov 30th)
Title: Evaluation safety of 2-Chloroethanol in food
(식품 중 2-클로로에탄올 안전성 평가)
Ministry of Food and Drug safety
2022 Ministry of Food and Drug safety (식품의약품안전처)
(￦50 million / 2022 March 1st ~ 2022 Sep 30th)
Title: Convergence health functional food safety management support and institutionalization
(융복합 건강기능식품안전관리 지원 및 제도화 사업)
Ministry of Food and Drug safety
2021 Ministry of Food and Drug safety (식품의약품안전처)
(￦195 million / 2021 Feb 1st ~ 2021 Nov 30th)
Title: Research for Evaluation of Health Functional Consumption Trend and Safety
(건강기능식품 섭취 실태조사 등 안전성 평가 체계 마련 연구)
Ministry of Food and Drug safety
2020 National Research Foundation Funds (한국연구재단)
(￦230 million / 2020 Sep 1st ~ 2023 Feb 28th)
Title: Development of amino acid mixture to alleviate liver disease susceptibility and its human prediction model based on prohibitin1
expression level
(간질환 민감성 완화 아미노산 복합제 개발 및 prohibitin 1 발현 수준에 따른 간질환 민감성 예측 인체 적용 모델 개발)
2020 Ewha Womans University (이화여자대학교)
(￦100 million / 2020 December 1st ~ 2022 May 31th)
Title: 편도유래줄기세포 기반 희귀난치성질환 융합치료 신기술 개발
Ewha Womans University, Korea
2020 Ministry of Food and Drug safety (식품의약품안전처)
(￦150 million / 2020 March 1st ~ 2020 Oct 31th)
A Study on the R&D Planning of Safety Management for Food, Agriculture, Forestry and Fisheries
(식품 및 농축수산 안전관리를 위한 기획연구)
Ministry of Food and Drug safety, Korea
2018 Ministry of Food and Drug safety (식품의약품안전처)
(￦40 million / 2018 June 1st ~ 2018 Oct 31th)
Title: Analysis and management plan of abnormal cases report according to multiple intake of health functional food
(건강기능식품 복수섭취에 따른 이상사례 신고 내용 분석 및 관리방안)
Ministry of Food and Drug safety, Korea
2016 National Research Foundation Funds (한국연구재단)
(￦200 million / 2016 Oct 1st ~ 2020 Sep 30th)
Title: Researches regarding the possibilities of prevention or treatment of liver disease including liver cancer using sulfur-containing
amino acid complexes (황함유 아미노산 복합체를 이용한 간 질환 및 간암의 예방 및 조기치료 가능성 연구)
National Research Foundation, Korea
2012 Korean Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries Fund
(농림수산식품기술기획평가원)
(￦170 million / 2012 December ~ 2015 December)
Title: Development of new beverages liquor containing Akebia quinata extracts with antioxidant activity and hepatoprotective effects
(으름의 기능성-항산화 및 간보호- 탐색 및 이를 활용한 음료 개발)
iPET Korea
2012 National Research Foundation Funds for New Researchers (한국연구재단)
(￦150 million / 2012 May 1st ~ 2015 April 30th)
Title: Basic mechanisms of regulations of H19 and insulin-like growth factor2 in liver-specific prohibitin1 knockout mice and
effects of provision of S-adenosylmethionine on liver disease progress
(간특이적 prohibitin1 knockout 생쥐에서의 H19과 insulin-like growth factor2의 조절 기작 및 S-adenosylmethionine의 급여가
간질환 진행에 미치는 영향에 관한 연구)
National Research Foundation, Korea