My research focuses on human host factors (genes and gut microbes) that impact susceptibility to tuberculosis infection, disease progression, and treatment outcome. Tuberculosis develops in a susceptible host and a highly adapted mycobacterium strain that constantly evolves to evade treatment modalities.

Sergei is interested in understanding the evolution of genes underlying autoimmune conditions. His research integrates techniques from population genetics and medical genetics. He integrates multiple layers of genome annotations: signals of selection, fine-mapped causal SNPs for autoimmune conditions, and various layers of functional annotations (chromatin accessibility, eQTLs, etc). 

Anastasia is interested in understanding molecular mechanisms underlying autoimmune conditions. Her work is focused on fine-mapping causal SNPs for autoimmune conditions by integrating functional annotations. 

Alexander is interested in reconstructing the genetic history of Russians and related Slavic-speaking populations using techniques based on Ancestral Recombination Graphs. More broadly, he is interested in how natural selection shaped the distribution of immune gene variants across populations and how genetic variation translates into similarities at the protein structure level.

Alena is interested in reconstructing genetic history of Russians  by combining ancient DNA techniqies and novel tools based on Ancestral Recombination Graphs.