Eva K Lee



Advancing knowledge, empowering decisions, transforming organizations

Power by Passion, Innovate with heart


Distinguished Scholar in Logistics

Professor in Computational Methods and Machine Learning

Research Interests

Mathematical programming and modeling

Large-scale optimization, machine learning, and predictive analytics

Healthcare policy, management, and decision

Homeland security and defense

Big data and high-performance computing

Business innovation

Biomedicine, clinical and translational research

Public health and medical preparedness

Selected News Highlights

Selected Papers


Published Papers and Proceedings


FM Martins, AP Vidal, J Giddaluru, B da Silva, EK Lee, P Zhang, LE Cardozo, CA Prete Jr, H Domingues, EC Sabino, VS Sampaio, W Monteiro, HI. Nakaya. Temporal and Spatial Analysis of over 7,000 Measles Cases Outbreak in the Brazilian Amazon. Open Forum Infectious Diseases 2022. To appear.


EK Lee, YF Liu, A El-Tahawy, FO Fasina. Analyzing Strategies for Containing Avian Influenza. AMIA Annu Symp Proc. 2022; 2022: 682–691. 


EK Lee, X Wei, MD Wright, F Baker-Witt, New PK/PD model directly links diabetes drug dose to blood glucose level for personalized care. AMIA Annu Symp Proc. 2022; 2022: 672–681. 

A Shapoval, A., EK Lee. Managing Guest Flow in Georgia Aquarium After the Dolphin Tales Show Opening. Oper. Res. Forum 3, 2022; 51:1-21. 


EK Lee, B Egan. A Multi-stage Multi-group Classification Model: Applications to Knowledge Discovery for Evidence-based Patient-centered Care.  In Proceedings of the 14th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management - Volume 1: 2022; 95-108. KDIR, ISBN 978-989-758-614-9, ISSN 2184-3228, 


EK Lee, YF Liu, F Yuan  FH Pietz. Strategies for Disease Containment: A Biological-Behavioral-Intervention Computational Informatics Framework. AMIA Annu Symp Proc. 2022 Feb 21;2021:687-696.


EK Lee, ZN Li, YB Wang, MS Hagen, R Davis, BM Egan. Multi-Site Best Practice Discovery: From Free Text to Standardized Concepts to Clinical Decisions. 2021 IEEE International Conference on Bioinformatics and Biomedicine. 2021: 2766-2773.


EK Lee, KD Cha. Dynamic Restricted Column Generation in MIQP for Cancer Radiation Therapy. 2021 IEEE International Conference on Bioinformatics and Biomedicine.2021: 2757-2765.


EK Lee, ZL Li, YK Liu, J LeDuc. Strategies for Vaccine Prioritization and Mass Dispensing. Vaccines 2021; 9 (5), 506-530.


A Shapoval, EK Lee. Generalizing 0-1 conflict hypergraphs and mixed conflict graphs: mixed conflict hypergraphs in discrete optimization. J Global Optimization 2021: 1-36.


EK Lee, K Uppal. OptSelect: An algorithm for ensemble feature selection and stability assessment. 2020 IEEE International Conference on Bioinformatics and Biomedicine. 2020: 1979-1986.


EK Lee, JH Lee. Competition Strategy for Healthcare Insurance Plans. 2020 IEEE International Conference on Bioinformatics and Biomedicine. 2020:1972-1978.

EK Lee, K Uppal. CERC: an interactive content extraction, recognition, and construction tool for clinical and biomedical text. BMC Medical Informatics and Decision Making  2020, 20 (14): 1-14.

EK Lee. Dieting, Physical Health, and Food Security. Journal of Physical Fitness, Medicine & Treatment in Sports. 2020; 8(2).

EK Lee, HZ Tian, HI Nakaya.  Antigenicity prediction and vaccine recommendation of human influenza virus A (H3N2) using convolutional neural networks. Human Vaccines & Immunotherapeutics, 2020; 16 (11): 2690-2708.

P Gonzalez-Dias, EK Lee, S Sorgi, DS de Lima, AH Urbanski, EL Silveira, HI Nakaya  . Methods for predicting vaccine immunogenicity and reactogenicity.  Human Vaccines & Immunotherapeutics 2020; 16 (2): 269-276 . 

EK Lee, Z Li. Devices, Systems, and Methods for Enhanced Patient Monitoring and Vigilance. US Patent App. 16/676,348. 2020. 

T Leonard, EK Lee . US-Mexico Border: Building a Smarter Wall through Strategic Security Measure Allocation. Journal of Strategic Innovation and Sustainability 15 (1): 156-182. 

EK Lee, K Uppal, S Er.  SEACOIN2. 0: an interactive mining and visualization tool for information retrieval, summarization and knowledge discovery. 2019 IEEE International Conference on Bioinformatics and Biomedicine.  2019;1518-1525. 

EK Lee, YB Wang, YT He, BM Egan. An Efficient, Robust, and Customizable Information Extraction and Pre-processing Pipeline for Electronic Health Records. In Proceedings of the 11th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management. 2019; 310-321. KDIR, ISBN 978-989-758-382-7. 

EK Lee, HZ Tian, J Lee, X Wei, J Neeld, KD Smith, AR Kaplan. Investigating a Needle-Based Epidural Procedure in Obstetric Anesthesia. AMIA Annu Symp Proc. 2018; 2018: 720–729.


EK Lee, ZX Wang, A Shapoval. Strategies for Inpatient Bed Management. J Health Med Informatics 9: 308. DOI: 10.4172/2157-7420.1000308.

EK Lee, HZ Tian, X Wei, J Lee, KD Smith, J Neeld, AR Kaplan. Factors Influencing Epidural Anesthesia for Cesarean Section Outcome.  2018 IEEE International Conference on Bioinformatics and Biomedicine. 2018; 1062-1069. 

EK Lee, X Wei, F Baker-Witt, MD Wright, A Quarshie. Outcome-driven personalized treatment design for managing diabetes. Interfaces 2018; 48 (5): 422-435. 

EK Lee.  Predicting antigenicity of human influenza virus A (H3N2) using deep learning. (Keynote speech) Journal of Pharmaceutical Sciences & Emerging Drugs  2018. ISSN: 2380-9477

EK Lee. Innovation in big data analytics: Applications of mathematical programming in medicine and healthcare. (Keynote speech) 2017 IEEE International Conference on Big Data (Big Data), 2017: 3586-3595.


A Shapoval, EK Lee. Optimizing inpatient bed capacity to improve care delivery. 2017 IEEE International Conference on Bioinformatics and Biomedicine. 2017: 855-860.

Di Kazmin, HI Nakaya, EK Lee, MJ Johnson, R van der Most, RA van den Berg, WR Ballou, Erik Jongert, U Wille-Reece, C Ockenhouse, A Aderem, DE Zak, J Sadoff, J Hendriks, J Wrammert, R Ahmed, and B Pulendran. Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.Proceedings of the National Academy of Science. 2017; 114(9) 2425–2430.

EK Lee, YB Wang, RA Davis, BM Egan. Designing a low-cost adaptable and personalized remote patient monitoring system. 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). 2017: 1040 - 1046. 

EK Lee, A Shapoval, Z Wang. Inpatient bed management to improve care delivery.2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). 2017: 1033-1039.

EK Lee, ZX Wang. A Computational Framework for Influence Networks: Application to Clergy Influence in HIV/AIDS Outreach. Proceedings of the 2017 IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining 2017: 1175-1182.

EK Lee, FH Pietz, CH Chen, Y Liu. An interactive web-based decision support system for mass dispensing, emergency preparedness, and biosurveillance. Proceedings of the 2017 International Conference on Digital Health, 2017: 137-146


EK Lee, YB Wang, RA Davis, BM Egan. A Low-cost Adaptable and Personalized Remote Patient Monitoring System. In Proceedings of the 2017 International Conference on Digital Health. ACM 2017; 155-156.

EK Lee, Y Liu, FH Pietz.  A computational framework for a digital surveillance and response tool: application to avian influenza. AMIA Annual Symposium Proceedings 2017, 2017: 1090-1099.

EK Lee, Z Li, L Ling, A Agarwal, M Wright,  A Quarshie. Reducing surgical-site infections for coronary artery bypass graft patients. 2016 IEEE International Conference on Bioinformatics and Biomedicine. 2016; 978-985.

WT Mahle, SC Nicolson, D Hollenbeck-Pringle, MG Gaies, MK Witte, EK Lee, M Goldsworthy, PC Stark, KM Burns, MA Scheurer, DS Cooper, R Thiagarajan, VB Sivarajan, S Colan, MS Schamberger, LS Shekerdemian.Utilizing a Collaborative Learning Model to Promote Early Extubation Following Infant Heart Surgery. Pediatric Critical Care Medicine.2016; 17(10): 939-947.

MJ Wolf, EK Lee, SC Nicolson, GD Pearson, MK Witte, J Huckaby, M Gaies, LS Shekerdemian, WT Mahle.Rationale and methodology of a collaborative learning project in congenital cardiac care. American Heart Journal. 2016; 174:129-137.

SE Holte, EK Lee, Y Mei.Symmetric directional false discovery rate control. Statistical Methodology. 2016 Dec 31;33:71-82.

WT Hu, K Watts, P Tailor, T Nguyen, J Howell; R Lee; N Seyfried; M Gearing; C Hales; A Levey; J Lah; EK Lee.CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease. Alzheimer’s Disease Neuro-Imaging Initiative. Acta Neuropathologica Communications. 2016;4(1):14. doi: 10.1186/s40478-016-0277-8.

EK Lee, YF Liu, FH Pietz.A Compartmental Model for Zika Virus with Dynamic Human and Vector Populations. American Medical Informatics Association Annu Symp Proc. 2016;2016:743-752.

EK Lee, YB Wang, MS Hagen, X Wei, RA Davis, BM Egan.Machine Learning: Multi-site Evidence-Based Best Practice Discovery. (Keynote speech) International Workshop on Machine Learning, Optimization and Big Data. 2016: 1-15.

EK Lee, H Nakaya, F Yuan, T Querec, F Pietz, BA Benecke, G Burel, B Pulendran. Machine learning framework for predicting vaccine immunogenicity. Interfaces – The Daniel H. Wagner Prize for Excellence in Operations Research Practice. 2016; 46(5): 368 - 390.

EK Lee, M Callahan, X Wei, PD Tailor, M Cole, M Wright.A systems approach to reducing central line associated blood stream infections. IEEE International Conference on Bioinformatics and Biomedicine. 2015; 948-955.

Contributor, Institute of Medicine.Transforming health care scheduling and access: getting to now. 2015 June. Washington, DC: The National Academies Press.

HI Nakaya, T Hagan, M Kwissad, EK Lee, et al.Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures. Immunity. 2015 Dec 15;43(6):1186-98.

EK Lee, HY Atallah, MD Wright, ET Post, C Thomas IV, DT Wu, LL Haley.Transforming emergency department workflow and patient care. Interfaces – The 2014 Franz Edelman Award Achievement in Operations Research. 2015; 45(1):58-82.

EK Lee, F Yuan, F Pietz, BA Benecke.Vaccine prioritization for effective pandemic response. Interfaces – 2014 The Daniel H. Wagner Prize for Excellence in Operations Research Practice. 2015; 45(5):425 - 443.

EK Lee, HJ Kang, D Cinalioglu, L Davis, G Frank.Systems modeling and simulation for reducing medication errors. IEEE International Conference on Bioinformatics and Biomedicine. 2014; 978-1-4799-9669: 35-42.

JP Brooks, EK Lee. Solving a multigroup mixed-integer programming-based constrained discrimination model. INFORMS Journal on Computing. 2014; 26(3): 567 - 585.

MS Hagen, EK Lee.BIOSPIDA: A relational translator and automatic storage for NCBI ASN.1 databases. International Conference on Big Data and Analytics in Healthcare. 11-29. Singapore, Jul 2014.

EK Lee, TL Wu, S Tal, J Jose. Medical alert management: An automated decision support tool to reduce alert fatigue. American Medical Informatics Association Annu Symp Proc. 2014; 845-854.

MS Hagen, JK Jopling, TG Buchman, EK Lee.Priority queuing models for hospital intensive care units and the impacts to severe case patients. American Medical Informatics Association Annu Symp Proc. 2013; 841-50.

C Koczor, R Torres, E Fields, A Boyd, S He, N Patel, EK Lee, A Samarel, W Lewis.Thymidine kinase and miDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation. Physiological Genomics. 2013; 45(14):590-6.

C Koczor, EK Lee, R Torres, A Boyd, J. Vega, K Uppal, F Yuan, E Fields, A Samarel, W Lewis.Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computational analysis. Physiological Genomics. 2013; 45(14):597-605.

KX Cao, N Lailler, YZ Zhang, et al.High resolution mapping of h1 linker histone variants in embryonic stem cells. PLOS Genetics. 2013; 9(4).

EK Lee, F Pietz, B Benecke, J Mason, G Burel.Advancing public health and medical preparedness with operations research. Interfaces - The Franz Edelman Award Achievement in Operations Research. 2013; 43(1): 79-98.

EK Lee, F Yuan, A Templeton, R Yao, K Kiel, JCH Chu.Biological planning for high-dose rate brachytherapy: Application to cervical cancer treatment. Interfaces - The Daniel H. Wagner Prize for Excellence in Operations Research Practice. 2013; 43(5): 462-476.

JH Park, EK Lee, QY Wang, J Li, QF Lin, C Pu.Health-Connect: An Ontology-Based Model-Driven Information Integration Framework and Its Application to Integrating Clinical Databases. Proceedings of the 2012 IEEE 13th International Conference on Information Reuse and Integration (IEEE IRI 2012). 2012; 393-400.

EK Lee, TL Wu, F Goldstein, A Levey. Predictive model for early detection of mild cognitive impairment and Alzheimer's disease. Optimization and Data Analysis in Biomedical Informatics. Fields Institute Communications. 2012; 63: 83-97.

CD Corley, R Arthur, RT Brigantic, C Bruckner-Lea, G Calapristi, JS Chung, G Dowling, D Hartley, S Kennedy, A Kircher, S Klucking, MJ Lancaster, T McKenzie, EK Lee, N Nelson, J Olsen, C Pancerella, T Quitugua, JT Reed, C Thomas, R Walters.Assessing the continuum of event-based bio surveillance through an operational lens. Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. 2012; 10(1):131-141.

EK Lee, F Yuan, D Hirsh, M Mallory, HK Simon.A clinical decision tool for predicting patient care characteristics: patients returning within 72 Hours in the emergency department. American Medical Informatics Association Annu Symp Proc. 2012; 2012: 495-504.

R Eguchi, K Elwood, EK Lee.The 2010 Canterbury and the 2011 Christchurch New Zealand Earthquakes and the 2011 Tohoku Japan Earthquake: Emerging Research Needs and Opportunities Workshop Report. Earthquake Engineering Research Institute and the U.S. National Science Foundation 2012.

EK Lee, CH Chen, N Brown, J Handy, A Desiderio, R Lopez, B Davis.Designing guest flow and operations logistics for the Dolphin Tales. Interfaces - The Daniel H. Wagner Prize for Excellence in Operations Research Practice, 2012; 42(5): 492-506.

M Artzrouni, CB Begg, R Chabiniok, J Clairambault, AJE Foss, J Hargrove, EK Lee, JH Siggers, M Tindall.The first international workshop on the role and impact of mathematics in medicine: a collective account. American Journal of Translational Research 2011; 3(5):492-497.

Contributor, Institute of Medicine and National Research Council. BioWatch and Public Health Surveillance: Evaluating Systems for the Early Detection of Biological Threats. 2011. Abbreviated Version. Washington, DC: The National Academies Press. (The unabbreviated version is classified.)

EK Lee, HR Lee, A Quarshie. SEACOIN -- An investigative tool for biomedical informatics researchers. American Medical Informatics Association Annu Symp Proc 2011; 750-759.

BT Denton, O Alagoz, A Holder, EK Lee.Medical decision making: open research challenges. IIE Transactions on Healthcare Systems Engineering. 2011; 1(3):161-167.

HI Nakaya, J Wrammert, EK Lee, et al.Systems biology of seasonal influenza vaccination in humans. Nature Immunology 2011; 12: 786-795.

B Pulendran, R Ahmed, E Lee, T Querec. Systems Biology Approach Predicts Immunogenicity of Vaccines. US12/935,347. 

EK Lee, K Cha. Automated data collection and integration for cancer treatment design and clinical quality evaluation investigations. 2010 American Medical Informatics Association Summit on Clinical Research Informatics 2010. (Competitive selection, 7%)

MS Hagen, EK Lee. BIOSPIDA: A relational database translator for NCBI. American Medical Informatics Association Annu Symp Proc 2010; 422-426.

EK Lee, A Mejia, T Senior, J Jose. Improving patient safety through medical alert management: an automated decision tool to reduce alert fatigue. American Medical Informatics Association Annu Symp Proc 2010; 417-421.

JJ Sturm, DA Hirsh, EK Lee, R Massey, B Weselman, HK Simon. Practice characteristics that influence nonurgent pediatric emergency department utilization. Academic Pediatrics 2010; 10(1): 70-74.

JP Brooks, EK Lee.  Analysis of the consistency of a mixed integer programming-based multi-category constrained discriminant model. Annals of Operations Research on Data Mining. 2010; 174(1): 147-168.

EK Lee, CH Chen, F Pietz, B Benecke. Disease propagation analysis and mitigation strategies for effective mass dispensing. American Medical Informatics Association Annu Symp Proc 2010; 427-431.

EK Lee. Mixed integer programming approach for cancer therapeutics. Paper for the 2009 National Science Foundation (NSF) Civil, Mechanical and Manufacturing Innovation Engineering Research and Innovation Conference. 1-9. Honolulu, Jun 2009.

MT McCabe, EK Lee, PM Vertino. A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Research 2009; 69(1):282-291.

EK Lee, HK Smalley, Y Zhang, F Pietz, B Benecke.  Facility location and multi-modality mass dispensing strategies and emergency response for biodefense and infectious disease outbreaks. International Journal on Risk Assessment and Management -- Biosecurity Assurance in a Threatening World: Challenges, Explorations, and Breakthroughs 2009;  12(2/3/4):311-351.

EK Lee.  Machine learning framework for classification in medicine and biology. Integration of AI and OR Techniques in Constraint Programming for Combinatorial Optimization Problems. Lecture Notes in Computer Science 2009; 5547:1-7. (Plenary speech)

EK Lee, CH Chen, F Pietz, B Benecke. Modeling and optimizing the public health infrastructure for emergency response. Interfaces - The Daniel H. Wagner Prize for Excellence in Operations Research Practice 2009; 39(5): 476-490.

TD Querec, R Akondy, EK Lee, W Cao, HI Nakaya, D Teuwen, A Pirani, K Gernert, J Deng, B Marzolf, K Kennedy, H Wu, S Bennouna, H Olouch, J Miller, RZ Vencio, M Mulligan, A Aderem, R Ahmed, B Pulendran. Systems biology approach predicts the immunogenicity of the yellow fever vaccine in humans. Nature Immunology 2009; 10:116-125.

Q Ling, C Pu, EK Lee. A model-driven approach to manage clinical data in relational databases. IEEE Bioinformatics and Biomedicine, Workshop on Biomedical and Health Informatics 2008. (Competitive selection, 8%)

PK Mehta, L Simpson, EK Lee, TA Lyle, ME McConnell, WM Book. Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. Texas Heart Institute Journal 2008; 35(3):256-261.

EK Lee. In case of emergency: a range of potential calamities--from a bioterrorist attack to a naturally occurring pandemic--demands fast, efficient, large-scale dispensing of critical medical countermeasures OR/MS Today. 2008; 35 (1): 28-35.

EK Lee. Modeling and optimization the public health infrastructure for emergency response. Modeling and Simulation for Emergency Management and Health Care Systems: Workshop Summary 2008.

A Jayashankar, U Udayasankar, S Sebastian, M Kalra, EK Lee, W Small. MDCT of thoraco-abdominal trauma: an evaluation of the success and limitations of primary interpretation using multiplanar reformatted images versus axial images. Emergency Radiology 2008; 15(1):29-34.

EK Lee. Optimization-based predictive models in medicine and biology. In: CJS Alves, PM Pardalos,  LN Vicente, eds. Optimization in Medicine. Springer Optimization and Its Applications. The Netherlands: Springer 2008;12:127-151.

EK Lee, M Zaider.  Operations research advances cancer therapeutics. Interfaces - The Franz Edelman Award Achievement in Operations Research 2008; 38(1):5-25.

JP Brooks and EK Lee.  Mixed integer programming constrained discrimination model for credit screening. In Proceedings of the 2007 Spring Simulation Multiconference, Business and Industry Symposium,1-6, Norfolk, VA, Mar 2007. ACM Digital Library.

EK Lee, KD Cha, T Bortfeld, JO Deasy. 4D-Image-Guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on The Use of Computers in Radiation Therapy. 2007;6205:1-5. (Competitive selection, 5%)

EK Lee, KD Cha, JO Deasy. Robust optimization to accommodate effects of systematic treatment uncertainties. In Proceedings for International Conference on The Use of Computers in Radiation Therapy 2007;6256:1-5. (Competitive selection, 5%)

EK Lee, TL Wu. Classification and disease prediction via mathematical programming. In: O Seref, OE Kundakcioglu, PM Pardalos, eds. Data Mining, Systems Analysis and Optimization in Biomedicine. AIP Conference Proceedings 2007; 953:1-42.

EK Lee. Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering - Systems Biology, Bioinformatics, and Computational Biology 2007; 35(6):1095-1109.

JP Brooks and EK Lee.  Solving a mixed-integer programming formulation of a multi-category constrained discrimination model. In Proceedings of the 2006 INFORMS Workshop on Artificial Intelligence and Data Mining1-6, 2006.

EK Lee, JO Deasy. Optimization in intensity-modulated radiation therapy. SIAG/OPT Views- and-News, Optimization in Medicine 2006; 17(2):20-32.

EK Lee, S Maheshwary, J Mason, W Glisson. Large-scale dispensing for emergency response to bioterrorism and infectious disease outbreak. Interfaces - OR Applications for Homeland Defense 2006; 36(6):591-607.

EK Lee, S Maheshwary, J Mason, W Glisson. Decision support system for mass dispensing of medications for infectious disease outbreaks and bioterrorist attacks. Annals of Operations Research- Computing and Optimization in Medicine and Life Sciences 2006; 148:25-53.

EK Lee, T Fox, I Crocker. Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. International Journal of Radiation Oncology, Biology, Physics 2006; 64(1):301-320.

FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino. DNA motifs associated with aberrant CpG island methylation. Genomics 2006; 87:572-579.

EK Lee, T Easton, K Gupta. Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research - Computing and Optimization in Medicine and Life Sciences 2006; 148:167-187.

JO Deasy, EK Lee, T Bortfeld, M Langer, K Zakarian, J Alaly, Y Zhang, H Liu, R Mohan, R Ahuja, A Pollack, J Purdy, R Rardin. A collaboratory for radiation therapy treatment planning optimization research. Annals of Operations Research - Computing and Optimization in Medicine and Life Sciences 2006; 148:55-63.

L Simpson, EK Lee, BJ Hott, DJ Vega, WM Book. Long-term results of angioplasty vs stenting in cardiac transplant recipients with allograft vasculopathy. The Journal of Heart and Lung Transplantation 2005; 24(9):1211-1217.

EK Lee, S Maheshwary, J Mason. Real-time staff allocation for emergency treatment response of biologic threats and infectious disease outbreak. Annals of Operations Research- Computing and Optimization in Medicine and Life Sciences. 2006; 148:25-53.

EK Lee, R Gallagher, A Campbell, M Prausnitz. Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra. IEEE Transactions on Biomedical Engineering 2004; 51(1):82-89.

EK Lee. Generating cutting planes for mixed integer programming problems in a parallel computing environment. INFORMS Journal on Computing 2004; 16(1):3-26.

L Simpson, PK Mehta, BJ Hott, JD Vega, EK Lee and WM Book. Long term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy. International society for heart and lung transplantation (ISHLT) 2004. (Competitive selection, 2%)

Bartholdi, J J., III, D. Dave, EK. Lee. Computing optimal load plans in less-than-truckload freight networks. Advances in Manufacturing, Logistics, and Supply Chain Management: Proceedings of the International Workshop in IT-Enabled Manufacturing, Logistics, and Supply Chain Management 2003;1-22.

JC Landry, M Koshy, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis. Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction. Proceedings of American Society of Clinical Oncology 2003;22: 297. (Competitive selection, 1%)

EK Lee, RJ Gallagher, D Patterson. A linear programming approach to discriminant analysis with a reserved judgment region. INFORMS Journal on Computing 2003; 15(1):23-41.

FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino. Predicting aberrant CpG island methylation. Proceedings of the National Academy of Sciences 2003; 100(21):12253-12258.

EK Lee, M Zaider. Intraoperative dynamic dose optimization in permanent prostate implants. International Journal of Radiation Oncology, Biology, Physics 2003; 56(3):854-861.

M Langer, EK Lee, JO Deasy, R Rardin, J Deye. Operations research applied to radiotherapy, an NCI-NSF - sponsored workshop February 7-9, 2002. International Journal of Radiation Oncology, Biology, Physics 2003; 57(3):762-768.

T Easton, K Hooker, EK Lee. Facets of the independent set polytope. Mathematical Programming B 2003; 98:177-199.

EK Lee, J Deasy, M Langer, R Rardin, J Deye, F Mahoney. Final report - NCI/NSF workshop on operations research applied to radiation therapy, Washington, DC, February 7-9, 2002. Annals of Operations Research - Optimization in Medicine 2003; 119:143-146.

EK Lee, T Fox, I Crocker. Integer programming applied to Intensity-modulated radiation therapy treatment planning. Annals of Operations Research - Optimization in Medicine 2003; 119:165-181.

EK Lee, M Zaider. Mixed integer programming approaches to treatment planning for brachytherapy - application to permanent prostate implants. Annals of Operations Research - Optimization in Medicine 2003; 119:147-163.

EK Lee, AYC Fung, JP Brooks, M Zaider. Automated tumor volume contouring in soft-tissue sarcoma adjuvant brachytherapy treatment. Physics in Medicine and Biology 2002; 47(11):1891- 1910.

J Linderoth, EK Lee, M Savelsbergh. A parallel linear programming based heuristic for large scale set partitioning problems. INFORMS Journal on Computing 2001; 13:191-209.

EK Lee, M Zaider. On the determination of an effective planning volume for permanent prostate implants. International Journal of Radiation Oncology, Biology, Physics 2001; 49(4):1197-1206.

EK Lee, T Fox, I Crocker. Optimization of radiosurgery treatment planning via mixed integer programming. Medical Physics 2000; 27(5):995-1004.

M Zaider, M Zelefsky, EK Lee, K Zakian, HA Amols, J Dyke, J Koutcher. Treatment planning for prostate implants using magnetic-resonance spectroscopy imaging. International Journal of Radiation Oncology, Biology, Physics 2000; 47(4):1085-1096.

CS Wuu, RD Ennis, PB Schiff, EK Lee, M Zaider. Dosimetric and volumetric criteria for selecting source activity and a source type (125I or 103Pd) in the presence of irregular seed placement in permanent prostate implants. International Journal of Radiation Oncology, Biology, Physics 2000; 47(3):815-820.

EK Lee. A linear-programming based parallel cutting plane algorithm for mixed integer programming problems. Proceeding for the Third Scandinavian Workshop on Linear Programming 1999; 22-31.

EK Lee, JE Mitchell. Computational experience of an interior-point SQP algorithm in a parallel branch-and-bound framework. In: Frenk, H., Roos, K., Terlaky, T., Zhang, S. (eds)  High Performance Optimization I 2000; 33: 329-347. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-3216-0_13 

EK Lee, R Gallagher, D Silvern, CS Wuu, M Zaider. Treatment planning for brachytherapy: an integer programming model, two computational approaches and experiments with permanent prostate implant planning. Physics in Medicine and Biology 1999; 44(1):145-165.


EK Lee, RJ Gallagher, M Zaider, Planning implants of radionuclides for the treatment of prostate cancer: an application of mixed integer programming.  OPTIMA (Mathematical Programming Society Newsletter) feature article, 1999; 61: 1-10.

RE Bixby, W Cook, A Cox, EK Lee. Computational experience with parallel mixed integer programming in a distributed environment. Annals of Operations Research - Parallel Optimization 1999; 90:19-43.

RE Bixby, EK Lee. Solving a truck dispatching scheduling problem using branch-and-cut. Operations Research 1998; 46(3):355-367.

EK Lee, D Silvern, R Gallagher, LG Stabile, RD Ennis, CR Moorthy, M Zaider.Treatment planning for permanent prostate implants: genetic algorithm versus integer programming. Medical & Biological Engineering & Computing 1997; 35: Supplement Part 2. (Competitive selection, 4%)

EK Lee, J Mitchell.Computational experience of an interior-point algorithm in a parallel branch-and-cut framework. Proceedings for SIAM Conference on Parallel Processing for Scientific Computing 1997;1-9.

M Ju¨nger, EK Lee, P Mutzel, T Odenthal. A polyhedral approach to the multi-layer crossing minimization problem. Proceedings of the International Symposium on Graph Drawing. Lecture Notes in Computer Science, LNCS. Springer-Verlag 1997; 1353:13-24.

RJ Gallagher, EK Lee. Mixed integer programming optimization models for brachytherapy treatment planning. Proceedings of the 1997 American Medical Informatics Association 1997;278-282. (Competitive selection, 5%)

EK Lee, JE Mitchel. Computational experience of an interior-point SQP algorithm in a parallel branch-and-bound framework. In Proceedings of High Performance Optimization Techniques 1997, 97-108. 

RJ Gallagher, EK Lee, D Patterson. Constrained discriminant analysis via 0/1 mixed integer programming. Annals of Operations Research - Non-Traditional Approaches to Statistical Classification and Regression 1997; 74:65-88.

EK Lee. On facets of knapsack equality polytopes. Journal of Optimization Theory and Applications 1997; 94(1):223-239.

EK Lee, J Mitchell. Computational experience in nonlinear mixed integer programming. The Operations Research Proceedings 1996;95-100.

EK Lee, RJ Gallagher. Mixed integer programming models for machine learning and discriminant analysis, Proceedings of ICIAM 95.Zeitschrift fur angewandte Mathmematik und Mechanik.1996;76(3)491-492

RJ Gallagher, EK Lee, D Patterson. An optimization model for constrained discriminant analysis and numerical experiments with iris, thyroid, and heart disease datasets. Proceedings of the 1996 American Medical Informatics Association 1996; 209-213. (Competitive selection, 5%)

Refereed Book Chapters


EK Lee, Collaborative systems analytics to advance clinical care: Application to congenital cardiac patients. Healthcare Policy, Innovation and Digitalization: Contemporary Strategy and Approaches. Accepted 2022. Springer.

– Finalist, 2018 Franz Edelman Award Achievement in practice excellence.


EK Lee, H Tian, X Wei, JH Lee. A patient-centered data-driven analysis of pain management via Epidural Anesthesia. In: Wang J (Ed). Encyclopedia of Data Science and Machine Learning. IGI Global, 2022; Chapter 5.


EK Lee, B Egan. Free Text to Standardized Concepts to Clinical Decisions. In: Wang J (Ed). Encyclopedia of Data Science and Machine Learning. IGI Global, 2022; Chapter 28.


EK Lee, GS Galis. Using pattern recognition and discriminant analysis of functional perfusion data to create “angioprints” for normal and perturbed angiogenic microvascular networks. In: Galis ZS (Ed). The Vasculome: From Many, One. 2022; Chapter 18.  219-228.  San Diego: Elsevier Inc./Academic Press.


EK Lee, CH Chen, YF Liu, F Pietz, B Benecke. A Software Suite for Public Health, Disaster Medicine and Emergency Response. In: S Chatterjee, RT Brigantic, AM Waterworth (Eds). Applied Risk Analysis for Guiding Homeland Security Policy and Decisions. 2021 Chapter 12: 297-324. John Wiley & Sons, Inc.

EK Lee, F Yuan, A Templeton, R Yao, K Kiel, JCH Chu.Biological Planning Optimization for High-Dose-Rate Brachytherapy and its Application to Cervical Cancer Treatment. In: N Kong, SF Zhang, eds. Decision Analytics and Optimization in Disease Prevention and Treatment.  2018; 261-284.  Wiley Series in Operations Research and Management Science.  


EK Lee. Machine Learning for Early Detection and Treatment Outcome Prediction. In: N Kong, SF Zhang, eds. Decision Analytics and Optimization in Disease Prevention and Treatment 2018; 367-400. Wiley Series in Operations Research and Management Science.

EK Lee. Applications of discrete optimization in medicine and healthcare. In: T Terlaky, M Anjos and S Ahmed, )Eds). Advances and Trends in Optimization with Engineering Applications. 2017; Vol 24: 93-103. Society for Industrial and Applied Mathematics. 

EK Lee. Predictive analytics: classification in medicine and biology. In: Y Hui, EK Lee, eds. Healthcare Analytics: From Data to Knowledge to Healthcare Improvement. Wiley Series in Operations Research and Management Science. John Wiley & Sons, Inc. 2016; 159-187.

EK Lee, HY Atallah, MD Wright, C Thomas, ET Post, DT Wu, LL Haley Jr.Systems Analytics: Modeling and Optimizing Clinic Workflow and Patient Care. In: Y Hui, EK Lee, eds. Healthcare Analytics: From Data to Knowledge to Healthcare Improvement. Wiley Series in Operations Research and Management Science. John Wiley & Sons, Inc. 2016; 261-302.

Special Issue Editors' Note: Wagner Prize Second-Place Winner Lee et al./Grady Health System. Interfaces - The Daniel H. Wagner Prize for Excellence in Operations Research Practice 2014; 44(5): 444.

EK Lee, FH Pietz, B Benecke.Service networks for public health and medical preparedness: medical countermeasures dispensing and large-scale disaster relief efforts. In: JW Hermann, ed. Handbook of Operations Research for Homeland Security. The Netherlands: Springer 2013:183:167-196.

EK Lee, AY Yang, F Pietz, B Benecke.Public health, emergency response, and medical preparedness I: Medical surge. In: JJ Cochran, ed. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley 2011. (DOI: 10.1002/9780470400531.eorms1041)

EK Lee, F Pietz, B Benecke.Public health, emergency response, and medical preparedness II: Medical countermeasures dispensing and large-scale disaster relief efforts. In: JJ Cochran, ed. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley 2011. (DOI: 10.1002/9780470400531.eorms1042)

EK Lee, AY Yang, T Guilford, F Pietz, B Benecke.Public health, emergency response, and medical preparedness III: Communication infrastructure. In: JJ Cochran, ed. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley 2011. (DOI: 10.1002/9780470400531.eorms1043)

EK Lee, AY Yang, F Pietz, B Benecke.Public health, emergency response, and medical preparedness IV: Emergency evacuation. In: JJ Cochran, ed. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley 2011.( DOI: 10.1002/9780470400531.eorms1046)

EK Lee, AY Yang, F Pietz, B Benecke.Public health and medical preparedness. In: Y Yih, ed. Handbook of Healthcare Delivery Systems. Boca Raton, FL: CRC Press, Taylor, Francis Group 2011:41-1: 1-42.

S Guerlain, EK Lee.Engineering the healthcare delivery system. Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2009 Symposium (2010). National Academy of Engineering of the National Academies, The National Academies Press, Washington D.C.

EK Lee, K Gupta.Algorithms for genomics analysis. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. 2nd. The Netherlands: Springer 2009:33-54.

EK Lee, TL Wu.Disease diagnosis: Optimization-based methods. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. 2nd. The Netherlands: Springer 2009:753-784.

EK Lee, JE Mitchell.Integer programming: Branch-and-bound methods. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. 2nd. The Netherlands: Springer 2009:1634-1643.

EK Lee, TL Wu.Classification and disease prediction via mathematical programming. In: PM Pardalos, HE Romeijn, eds. Handbook of Optimization in Medicine, Chapter 12. Springer Optimization and Its Applications. The Netherlands: Springer 2009:26:381-430.

EK Lee, K Gupta.Algorithms for genomics analysis. In: PM Pardalos, HE Romeijn, eds. Handbook of Optimization in Medicine, Chapter 9. Springer Optimization and Its Applications. The Netherlands: Springer 2009:26:291-323.

EK Lee, TL Wu, JP Brooks. Classification and disease prediction via mathematical programming. In: GJ Lim, EK Lee, eds. Optimization in Medicine and Biology, Chapter 1. Boca Raton, FL: Auerbach Publications, Taylor, Francis Group 2008:3-60.

EK Lee, K Gupta.Algorithms for genomics analysis. In: GJ Lim, EK Lee, eds. Optimization in Medicine and Biology, Chapter 12. Boca Raton, FL: Auerbach Publications, Taylor, Francis Group 2008:355-393.

EK Lee, DP Lewis.Integer programming for telecommunications. In: MGC Resende, PM Pardalos, eds. Handbook of Optimization in Telecommunications, Chapter 3. The Netherlands: Springer 2006:67-102.

EK Lee, M Zaider.Optimization and decision support in brachytherapy treatment planning.In: ML Brandeau, F Sainfort, WP Pierskalla, eds. Operations Research and Health Care: A Handbook of Methods and Applications, Chapter 28. International Series in Operations Research; Management Science, Vol 70. The Netherlands: Kluwer Academic Publishers 2004:722-740.

M Zaider, EK Lee.Treatment planning for low dose rate and high dose rate brachytherapy. In: AP Dicker, GS Merrick, FM Waterman, RK Valicenti, LG Gomella, eds. Basic and Advanced Techniques in Prostate Brachytherapy, Chapter 12. The United Kingdom: Taylor,Francis Group 2005:143-156.

EK Lee.Branch-and-bound methods. In: PM Pardalos, MGC Resende, eds. Handbook of Applied Optimization, Chapter 3, Section 2. New York, NY: Oxford University Press USA 2002. (Honorable mention by the Association of American Publishers’ Outstanding Professional and Scholarly Titles of 2002 in Computer Science.)

EK Lee, JE Mitchell.Integer programming: Branch and bound methods. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. The Netherlands: Kluwer Academic Publishers 2001:1049-1059.

Edited Volumes

H Yang, and EK Lee, eds.Healthcare Analytics: From Data to Knowledge to Healthcare Improvement. John Wiley & Sons, 2016.

Y Hui, EK Lee.Healthcare Data Analytics: Wiley Series in Operations Research and Management Science. Hoboken NJ: John Wiley & Sons, Inc 2015.

EK Lee.Operations Research for Medical Decision Making: Springer International Series in Operations Research and Management Science. The Netherlands: Springer Science 2015.

EK Lee, A Sofer, Computer Science Series.Computing and Optimization in Medicine and Life Sciences. The Netherlands: Springer Science 2012.

EK Lee, G Limo.Optimization in Medicine and Biology. Boca FL: Taylor and Francis Auerbach Publications 2008.

EK Lee, A Sofer, Computer Science Series.Computing and Optimization in Medicine and Life Sciences, Volume 2. The Netherlands: Springer Science 2006.

EK Lee, A Sofer.Computing and Optimization in Medicine and Life Sciences, Volume 1. The Netherlands: Springer Science, Kluwer Academic Publishers 2003.

Reviewed Biological/Medical Abstracts

EK Lee, F Yuan, A Templeton, R Yao, K Kiel, JCH Chu.Optimizing tumor control probability in radiation therapy treatment – application to HDR cervical cancer. Medical Physics 2016; 43(6): 3806.

WT Mahle, S Nicolson, LS Shekerdemian, MG Gaies, MK Witte, EK Lee, M Goldsworthy, P Stark, KM Burns, MA Scheurer, DS Cooper, R Thiagarajan, B Sivarajan, D Hollenbeck-Pringle, S Colan.Utilizing a collaborative learning model to decrease length of postoperative ventilation following infant heart surgery. Circulatio 2015; 132(3): A9997-A9997. American Heart Association.

EK Lee, HJ Kang, D Cinalioglu, L Davis, G Frank.Systems modeling and simulation for reducing medication errors. Pediatric Academies 2013; 2910.103.

EK Lee, F Pietz.SU-E-I-89: Real-time information and decision support for radiological emergency response. Medical Physics 2013; 40(6):146.

EK Lee, F Yuan, A Templeton, R Yao, K Kiel, JCH Chu.SU-D-500-1:TCP-driven biological planning for high-dose rate brachytherapy. Medical Physics 2013;40(6):105.

EK Lee, F Yuan, A Templeton, R Yao, K Kiel, JCH Chu.TCP-driven biological planning for high-dose rate brachytherapy. International Journal of Radiation Oncology Biology Physics 2013; 87(25): S415-2551.

EK Lee, DA Hirsh, HK Simon.A clinical decision support tool for predicting patient readmission in the pediatric emergency department. Pediatric Academies 2012; 2938.598.

EK Lee, F Yuan, R Yao, J Chu.PET-image TCP-driven biological planning for cervical cancer high-dose rate brachytherapy. Medical Physics 2011;38:3627.

EK Lee, KD Cha, JO Deasy and C Hamilton.Handling multiple clinical objectives in intensity modulated radiation therapy treatment planning. Medical Physics 2010; 37 (6):3214.

EK Lee, F Yuan, A Templeton, R Yao, JC Chu.PET-Image guided dose escalation in high-dose rate radiation therapy. International Journal of Radiation Oncology Biology Physics 2010;78(3):S415.

EK Lee, KD Cha, and M Zaider.Automated Planning Volume Definition for HDR Brachytherapy:Application to Intraluminal Treatment of the Bile Duct. Medical Physics 2009; 36(6):2530.

EK Lee, and KD Cha.Image-guided Adaptive Treatment Planning Optimization for IMRT. Medical Physics 2009; 236(6):2538.

M McCabe, EK Lee, P Vertino.Multi-factorial prediction of aberrant CpG island methylation in cancer. AACR Special Conference Cancer Epigenetics 2008; A73.

EK Lee, KD Cha, T Bortfeld, JO Deasy.4D image-guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on The Use of Computers in Radiation Therapy 2007;6205:1-5.

EK Lee, KD Cha, JO Deasy.Robust optimization to accommodate effects of systematic treatment uncertainties. Medical Physics 2007; 34(6):2523-2524.

EK Lee, KD Cha, JO Deasy.Robust optimization to accommodate effects of systematic treatment uncertainties. Proceedings for International Conference on The Use of Computers in Radiation Therapy 2007; 6256:1-5.

M McCabe, EK Lee, P Vertino.Multi-Factorial prediction of aberrant CpG island methylation in Cancer, The Sixth Georgia Tech - Oak Ridge International Conference on Bioinformatics - In silico Biology: Gene Discovery and Systems Genomics 2007;35.

M McCabe, EK Lee, P Vertino.Predicting methylation-prone CpG islands in human cancer. Proc. Amer. Assn. Cancer Res 2007; 48:2839.

EK Lee.Large-scale pattern recognition and classification approaches for disease diagnosis. Biomedical Engineering Systems Biology and Bioinformatics 2006.

EK Lee, D Lewis, KD Cha.Efficient IMRT Delivery - Fast generation of integer-valued beam profiles. Medical Physics 2006; 33(6): 2096.

EK Lee, KD Cha, T Bortfeld, JO Deasy.4D image-guided treatment planning optimization for managing respiratory effect in radiotherapy planning. Medical Physics 2006; 33(6) 2191-2192.

EK Lee, M Zaider.Incorporating biological metabolite information within treatment of prostate carcinoma and analysis of dose escalation effect. International Journal of Radiation Oncology Biology Physics 2006; 66(3)(Suppl 1): S572-S573.

EK Lee, FA Feltus, JF Costello, C Plass, PM Vertino.Large-scale genomic pattern recognition and classification of aberrantly hypermethylated CpG island loci in human cancer. The Fifth Georgia Tech - Oak Ridge International Conference on Bioinformatics - Computational Genomics and Evolutionary Biology,2005:62.

EK Lee, D Lewis.Fast integer-valued smoothing of beam profiles in intensity modulated Radiation Therapy. Medical Physics 2005; 32(6):1974.

EK Lee, T Bortfeld, JO Deasy.Robust optimization including effects of systematic treatment errors. Medical Physics 2005; 32(6):1978.

FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino.DNA patterns associated with CpG island methylation state. The Fifth Georgia Tech - Oak Ridge International Conference on Bioinformatics - Computational Genomics and Evolutionary Biology 2005;50.

P Mehta, L Simpson, EK Lee, T Lyle, W Book.Endothelin-receptor antagonists improve exercise tolerance and oxygen saturations in adults with the Eisenmenger Syndrome. American Heart Association Scientific Sessions 3190 2005.

EK Lee, KD Cha, T Bortfeld, JO Deasy.Multistage treatment planning optimization for managing organ motion in radiotherapy planning. International Journal of Radiation Oncology Biology Physics 2005;63(Suppl 1):S209-S210.

EK Lee, KD Cha, T Bortfeld, JO Deasy.Multistage treatment planning optimization for managing organ motion in radiotherapy planning. Medical Physics 2005; 32(6):1925.

EK Lee, T Easton, K Gupta.Novel evolutionary models and applications to the sequence alignment problem. The Fifth Georgia Tech - Oak Ridge International Conference on Bioinformatics - Computational Genomics and Evolutionary Biology 2005;63.

EK Lee, KD Cha, J Shi.Automated data collection and integration for cancer treatment design and clinical quality evaluation investigation. Joint BECON/BISTIC 2004 Symposium Biomedical Informatics for Clinical Decision Support: A Vision for the 21st Century 2004;P23.

EK Lee.Handling multiple clinical objectives in intensity modulated radiation therapy treatment planning. 46th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2004; 31(6):1777.

J Deasy, EK Lee, M Langer, T Bortfeld, Y Zhang, H Liu, R Mohan, R Ahuja, J Dempsey, A Pollack, J Rosenman, A Eisbruch, R Rardin, J Purdy, C Zakarian, J Alaly.An IMRT treatment planning research collaborator- 46th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2004; 31(6):1775.

EK Lee.Optimization techniques and their suitability and robustness for IMRT planning. 46th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2004; 31(6):1762.

EK Lee, M Zaider.Incorporating biological metabolite information within treatment of prostate carcinoma. International Journal of Radiation Oncology, Biology and Physics 2004; 60(1):S370-371.

EK Lee, R Wagman, M Zaider.Treatment planning with automated planning volume definition for HDR brachytherapy - Application to intraluminal treatment of the bile duct. International Conference on Translational Research and Pre-Clinical Strategies in Clinical Radio-Oncology - ICTR 2003 Advances In Translational Radiation Oncology: From Molecular Signaling to Cancer Cure 2003;36:2530.

EK Lee, JO Deasy, I El Naqa, I Kawrakow, M Vicic.Integrating a Monte Carlo based optimization module into CERR for designing IMRT plans- 45th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2003; 30(6):1324.

EK Lee, M Zaider.Intraoperative dynamic dose optimization in permanent prostate implants. International Conference on Translational Research and Pre-Clinical Strategies in Clinical Radio- Oncology - ICTR 2003 Advances In Translational Radiation Oncology: From Molecular Signaling to Cancer Cure 2003;56(3)854-961.

M Koshy, JC Landry, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis.Potential for toxicity reduction using intensity modulated radiation therapy (IMRT) For retroperitoneal sarcoma. International Journal of Radiation Oncology, Biology, Physics 2003;57(2):S448-9.

EK Lee, T Fox, I Crocker.Beam geometry and intensity map optimization in IMRT via computational optimization. 45th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2003; 30(6):1385-1386.

M Koshy, JC Landry, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis.Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction. American Radium Society Houston, Texas. Cancer Journal Scientific American 2003;7(3-4):137-148.

FA Feltus, JF Costello, C Plass, EK Lee, PM Vertino.Identifying sequence patterns associated with aberrant CpG island methylation. Proceedings of American Association of Cancer Research LB:3 2002.

EK Lee, T Fox, I Crocker.Mixed integer programming techniques applied to IMRT treatment planning optimization. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2002; 29(6):1259.

JO Deasy, EK Lee, I Kawrakow, C Zakarian.A prototype Monte Carlo-based IMRT treatment planning research system. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2002; 29(6):1254.

EK Lee, K Godette, C Anderson, J Keller.Effect of race and radiation treatment modalities on biochemical failure in prostate cancer cases. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2002;29(6).

EK Lee, M Zaider.Intra-operative dynamic dose optimization for prostate permanent implants. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics 2002; 29(6):1228.

EK Lee.An innovative computerized treatment planning system for permanent prostate implants. The American Association for the Advancement of Science 2001 Annual Meeting & Science Innovation Exposition, A41, February 2001. Invited presentation with media briefings

EK Lee, T Fox, I Crocker.Computational optimization for brain tumor radiosurgery treatment planning. 43rd American Association of Physicists in Medicine Annual Meeting, Salt Lake City Utah, July 2001. Medical Physics 2001; 28(6):1304,.

EK Lee, AY Fung, M Zaider.Automated planning volume contouring in soft-tissue sarcoma adjuvant brachytherapy treatment. International Journal of Radiation Oncology, Biology, Physics 2001; 51(3): 391.

M Zaider, EK Lee.MRS-guided dose-escalation treatment planning optimization for permanent prostate implants. 2nd International Innovative Solutions for Prostate Cancer Care meeting 2001;36.

EK Lee, M Zaider.Intraoperative iterative treatment plan optimization for prostate permanent implants. 2nd International Innovative Solutions for Prostate Cancer Care meeting 2001; 32-33.

EK Lee, M Zaider, M Zelefsky.On the definition of effective planning volume in permanent prostate implants. International Journal of Radiation Oncology, Biology and Physics 1999; 45(3):261-262.

M Zaider, EK Lee, K Zakian, HA Amols, M Zelefsky, J Dyke, J Koutcher.Intensity-modulated conformal treatment planning for prostate implants using biological imaging. International Journal of Radiation Oncology, Biology and Physics 1999; 45(3):351.

Contact Dr. Lee at evalee-gatech@pm.me

Courses

ISyE 6679 Computational Methods: Spring 2008,2010,2012,2014, Fall 2010,2013-2019

ISyE 6669 Deterministic Optimization: Spring 2015,2019.

ISyE 6662 Optimization II: Spring 2002.

ISyE 6662 Optimization II -- Part II:Integer Programming: Winter 1998.

ISyE 4803/8813/8901/4699/HS 8803 Operations Research in Medicine and HealthCare: Spring 2012-2016.

ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare: Spring 2009-2011.

ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare: Spring 2006,2007.

ISyE 4803 Topics in Optimization -- Applications to Real-World Problems: Spring 2000.

ISyE 4601 Senior Design: Spring 2008.

ISyE 4231 Engineering Optimization : Spring 2003(Section B), Spring 2004,2005(Section C).

ISyE 4104 Senior Design: Spring 2001.

ISyE 3231 Deterministic Operations Research: Fall 1997,1998.

ISyE 3133 Engineering Optimization (Section B): Spring 2007, Fall 2012.

BIOL 8802/BIOL 8803/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology: Fall 2002-2016.

BIOL 8802 Topics in Bioinformatics: Spring 2004.

HS 6400 Health Systems Delivery: Fall 2012.

(Emory)BIOS 509 Biomedical Informatics in Clinical Research: Spring 2008.

(Columbia) IEOR 6608 Integer Programming: Spring 1996.

(Columbia) IEOR 4600 Applied Integer Programming: Spring 1997.

(Columbia) IEOR 4004 Introduction to Operations Research -- Deterministic Models: Spring 1997.

Hobbies