Publications

Full publication list (†Indicates co-first authorship; * indicates (co-) corresponding authorship)

Google Scholar: Eunju Nam

32.  Multivalent Interactions Mediate SNAIL Transcription Factor Stimulation of the Nucleosome Deacetylase Activity of the CoREST Complex

Eunju Nam, Manuel Osorio Valeriano, Zhipeng A. Wang, Samuel D. Whedon, Hanjie Jiang, Maggie Xinran Zhang, Sarah Duboys-Coyne, Ishraq Haque, Jennifer Jiang, Jennifer Ferrira, Lucas Farnung, Kwangwoon Lee,* Philip A. Cole* 2026, In Revision

31.  Structural Basis of Cooperative COMPASS Activation by Histone Acetylation and Ubiquitination

Pablo De Loannes, Samuel D. Whedon, Max Haase, Zhipeng A. Wang, Eunju Nam, Amanda Waterbury, Brendan Camellato, Rachel Lee, Igor Valencia, Jef Boeke, Philip A. Cole,* Karim-Jean Armache* 2026, In Revision

30.  Histone modification cross-talk: analytical tools and molecular mechanisms

Jennifer Jiang,† Sarah DuBois-Coyne,† Eunju Nam,† Samuel D Whedon,† Kwangwoon Lee,* Philip A. Cole* Biochem. J. 2026, 483, 713-740.

29.  CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity

Robert J. Fisher, Kihyun Park, Kwangwoon Lee, Katarina Pinjusic, Allison Vanasse, Christina S. Ennis, Parisa Farokh, Scott B. Ficarro, Jarrod A. Marto, Hanjie Jiang, Eunju Nam, Stephanie Stransky, Joseph Duke-Cohan, Melis A. Akinci, Anupa Geethadevi, Eric Raabe, Ana Fiszbein, Shadmehr Demehri, Simone Sidoli, Chad W. Hicks, Derin B. Keskin, Catherine J. Wu, Philip A. Cole, Rhoda M. Alani* JCI Insight 2025, 11, e1902887

28. Interactions with Tau's Microtuble-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity

Mingeun Kim, Yuxi Lin, Eunju Nam, Dong Min Kang, Sungsu Lim, Yun Kyung Kim, Young-Ho Lee,* Mi Hee Lim* Nat. Chem. Biol. 2025, 21, 1709-1718.

27.  Structural and Enzymatic Plasticity of SIRT6 Deacylase Activity

Zhipeng A. Wang, Jonathan Markert, Maheeshi Yapa Abeywardana, Samual D. Whedon, Xinlei Sheng, Eunju Nam, Kwangwoon Lee, Maggie Chen, Amanda Waterbury, Yingming Zhao, Lucas Farnung,* Philip A. Cole* J. Biol. Chem. 2025, 301, 108446.

26.  UM171 Glues Asymmetric CRL3–HDAC1/2 Assembly to Degrade CoREST Corepressors

Megan J.R. Yeo,† Olivia Zhang,† Xiaowen Xie,† Eunju Nam,† N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas Chen, Khanh Nguyen, Hanjie Jiang, Zhipeng Wang, Kwangwoon Lee, Haibin Mao, Stefan A. Harry, Idris Barakat, Mariko Takahashi, Amanda L. Waterbury, Marco Barone, Andrea Mattevi, Steven A. Carr, Namrata D. Udeshi, Liron Bar-Peled, Philip A. Cole, Ralph Mazitschek, Brian B. Liau,* Ning Zheng* Nature 2025, 639, 232-240.

25.  Converging Mechanism of UM171 and KBTBD4 Neomorphic Cancer Mutations

Xiaowen Xie,† Olivia Zhang,† Megan J.R. Yeo,† Ceejay Lee,† Ran Tao, Stefan A. Harry, N. Connor Payne, Eunju Nam, Leena Paul, Y. Li, Hui Si Kwok, Hanjie Jiang, Haibin Mao, Jennifer L. Hadley, Hong Lin, Melissa Batts, Pallavi M. Gosavi, Vincenzo D’Angiolella, Philip A. Cole, Ralph Mazitschek, Paul A. Northcott, Ning Zheng,* Brian B. Liau* Nature 2025, 639, 241-249.

24.  Distinct Aggregation Behavior of N-terminally Truncated Aβ4-42 over Aβ1-42 in the Presence of Zn(II)

Chanju Na,† Mingeun Kim,† Gunhee Kim, Yuxi Lin, Young-Ho Lee, Wojciech Bal,* Eunju Nam,* Mi Hee Lim* ACS Chem. Neurosci. 2025, 16, 732-744.

23.  Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1

Kwangwoon Lee, Marco Barone, Amanda L. Waterbury, Hanjie Jiang, Eunju Nam, Sarah E. DuBois-Coyne, Samuel D. Whedon, Zhipeng A. Wang, Jonatan Caroli, Katherine Neal, Brian Ibeabuchi, Zuzer Dhoondia, Mitzi Kuroda, Brian B. Liau, Samuel Beck,* Andrea Mattevi,* Philip A. Cole* Nat. Chem. Biol. 2025, 21, 227-237.

22.  APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer's Disease

Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han,* Mu-Hyun Baik,* Young-Ho Lee,* Mi Hee Lim* Adv. Sci. 2024, 11, 2307182.

Note: This paper was highlighted in multiple media and Hot Topic "Amyloids".

21.  Circular Engineered Sortase for Interrogating Histone H3 in Chromatin

Samuel D. Whedon,† Kwangwoon Lee,† Zhipeng A, Wang,† Emily Zahn, Congcong Lu, Maheeshi Yapa-Abeywardana, Louise Fairall, Eunju Nam, Sarah Dubois-Coyne, Pablo De Ioannes, Xinlei Sheng, Adelina Andrei, Emily Lundberg, Jennifer Jiang, Karim-Jean Armache, Yingming Zhao, John W. R. Schwabe, Mingxuan Wu,* Benjamin A. Garcia,* Philip A. Cole* J. Am. Chem. Soc. 2024, 146, 33914-33927.

20.  Dual O2-Mediated Reactivity of a Mononuclear Cobalt Complex with Amyloid-β Peptides

Jong-Min Suh, Wooyeol Ryu, Eunju Nam, Nam Kwon, Kyungmin Kim, Dongwook Kim, Jaeheung Cho,* Kiyoung Park,* Mi Hee Lim* ACS Catal. 2024, 14, 14497-14508.

19.  Multifaceted regulation of Sirtuin 2 (Sirt2) Deacetylase Activity

Maheeshi Yapa Abeywardana, Samuel D. Whedon, Kwangwoon Lee, Eunju Nam, Rafael Dovarganes, Sarah Dubois-Coyne, Zhipeng A. Wang,* Philip A. Cole* J. Biol. Chem. 2024, 300, 107722.

18.  Unveiling the Impact of Oxidation-driven Endogenous Protein Interactions on the Dynamics of Amyloid-β Aggregation and Toxicity

Zhi Du,† Eunju Nam,† Yuxi Lin,† Mannkyu Hong, Tamás Molnár, Ikufumi Kondo, Koichiro Ishimori, Mu-Hyun Baik, Young-Ho Lee,* Mi Hee Lim* Chem. Sci. 2023, 14, 5340-5349.

Note: This paper was selected as a "WeChat Promotion Article" and an article for the 2023 Chemical Science HOT Article Collection.

17.  Conformational and Functional Changes of the Native Neuropeptide Somatostatin Occur in the Presence of Copper and Amyloid-β

Jiyeon Han, Jeongcheol Shin, Jiwon Yoon, Eunju Nam, Tongrui Qian, Yulong Li, Kiyoung Park,* Seung-Hee Lee,* Mi Hee Lim* Nat. Chem. 2022, 14, 1021-1030.     

Note: This paper was highlighted in multiple media.

16.  Distinct Impact of Glycation towards the Aggregation and Toxicity of Murine and Human Amyloid-β

Eunju Nam, Jiyeon Han, Sunhee Choi, Mi Hee Lim* Chem. Commun. 2021, 57, 7637-7640.

Note: This paper was contributed to the Special Issue of "Multimolecular Crowding in Biosystems" and selected as “HOT Article” from the Chemical Communication.

15.  Synaptic Copper, Amyloid-β, and Neurotransmitters in Alzheimer’s Disease

Eunju Nam, Geewoo Nam, Mi Hee Lim* Biochemistry 2020, 59, 15-17.

Note: This paper was contributed to the Special Issue of "The Future of Biochemistry: The Asia-Pacific Issue".

14.  Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia

Mingeun Kim,† Juhye Kang,† Misun Lee,† Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Jiyong Park, Soo jin Oh, Ji-Yoon, Lee, Joo-Yong Lee,* Mu-Hyun Baik,* Mi Hee Lim* J. Am. Chem. Soc. 2020, 142, 8183-8193.

Note: This paper was selected as an “ACS Editors' Choice”, highlighted in multiple media, and awarded as the “2020 Domestic Bio-field Research Achievement and News Top 5 (BRIC)”.

13.  Tunable Regulatory Activities of 1,10-Phenanthroline Derivatives towards Acid Sphingomyelinase and Zn(II)–Amyloid-β

Yelim Yi,† Jiyeon Han,† Min Hee Park, Nahye Park, Eunju Nam, Hee Kyung Jin,* Jae-sung Bae,* Mi Hee Lim* Chem. Commun. 2019, 55, 5847-5850.

Note: This paper was featured as the “Front Cover” from Chemical Communication.

12.  Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid‑β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease

Eunju Nam,† Jeffrey S. Derrick,† Seunghee Lee,† Juhye Kang, Jiyeon Han, Shin Jung C. Lee, Su Wol Chung,* Mi Hee Lim* ACS Chem. Neurosci. 2018, 9, 2655-2666.

11.  Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring Amyloid-β Aggregation

Sonam Kim,† Hyuck Jin Lee,† Eunju Nam,† Donghyun Jeong, Jaeheung Cho,* Mi Hee Lim,* Youngmin You* ACS Omega 2018, 3, 5141-5154.

10.  Link of Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons

Eunju Nam,† Jiyeon Han,† Jong-Min Suh, Yelim Yi, Mi Hee Lim* Curr. Opin. Chem. Biol. 2018, 43, 8-14.

9.  Towards an Understanding of Amyloid-β Oligomers: Characterization, Toxicity Mechanisms, and Inhibitors

Shin Jung C. Lee,† Eunju Nam,† Hyuck Jin Lee, Masha G. Savelieff, Mi Hee Lim* Chem. Soc. Rev. 2017, 46, 310-323.

8.  A Highly Selective Turn-on Chemosensor for Zn(II) in Aqueous Media and Living Cells

Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim, Cheal Kim,* Roger G. Harrison* Spectrochim. Acta A Mol. Biomol. Spectrosc. 2017, 178, 203-211.

7.  A Highly Selective Turn-on Chemosensor for Zn(II) in Aqueous Media and Living Cells

Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim,* Cheal Kim* Sens. Actuators B Chem. 2017, 244, 1045-1053.

6.   Mechanistic Insights into Tunable Metal-mediated Hydrolysis of Amyloid-β Peptides

Jeffrey S. Derrick, Jiwan Lee, Shin Jung C. Lee, Yujeong Kim, Eunju Nam, Hyeonwoo Tak, Juhye Kang, Misun Lee, Sunhee Kim,* Kiyoung Park,* Jaeheung Cho,* Mi Hee Lim* J. Am. Chem. Soc. 2017, 139, 2234-2244.

Note: This paper was selected as “Front Cover” and “Spotlights” from Journal of the American Chemical Society.

5.  A Highly Selective Fluorescent Sensor for the Detection of Al(III) and CN− in Aqueous Solution: Biological Applications and DFT Calculations

Tae Geun Jo, Jae Jun Lee, Eunju Nam, Kwon Hee Bok, Mi Hee Lim* Cheal Kim* New J. Chem. 2016, 40, 8918-8927.

4.  The Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease

Jeffrey S. Derrick, Richard A. Kerr, Kyle J. Korshavn, Michael McLane, Juhye Kang, Eunju Nam, Ayyalusamy Ramamoorthy,* Brandon T. Ruotolo,* Mi Hee Lim*  Inorg. Chem. 2016, 55, 5000-5013.

3.  In Cellulo Mapping of Subcellular Localized Bilirubin

Jong-Seok Park, Eunju Nam, Hye-Kyeong Lee, Mi Hee Lim,* Hyun-Woo Rhee* ACS Chem. Biol. 2016, 11, 2177-2185.

 Note: This paper was selected by F1000. 

1.  A PET-based Fluorometric Chemosensor for Determination of Mercury(II) and pH, and Hydrolysis Reaction-based Colorimetric Detection of Hydrogen Sulfide

Jae Jun Lee, Yong Sung Kim, Eunju Nam, Sun Young Lee, Mi Hee Lim,* Cheal Kim* Dalton Trans. 2016, 45, 5700-5712.