Publications

Full publication list (†Indicates co-first authorship; * indicates (co-) corresponding authorship)

Google Scholar: Eunju Nam

Manuscripts in Preparation

32. Eunju Nam, Manuel Osorio Valeriano, Zhipeng A. Wang, Samuel D. Whedon, Hanjie Jiang, Maggie Xinran Zhang, Sarah Duboys-Coyne, Ishraq Haque, Jennifer Jiang, Jennifer Ferrira, Lucas Farnung, Kwangwoon Lee,* Philip A. Cole* 2026, In Revision

"Multivalent Interactions Mediate SNAIL Transcription Factor Stimulation of the Nucleosome Deacetylase Activity of the CoREST Complex "           

31. Jennifer Jiang,† Sarah Dubois-Coyne,† Eunju Nam,† Samuel D. Whedon,† Kwangwoon Lee,* Philip A. Cole* 2026, In Revision

"Histone Modification Crosstalk: Analytical Tools and Molecular Mechanisms"

30. Pablo De Loannes, Samuel D. Whedon, Max Haase, Zhipeng A. Wang, Eunju Nam, Amanda Waterbury, Brendan Camellato, Rachel Lee, Igor Valencia, Jef Boeke, Philip A. Cole,* Karim-Jean Armache* 2026, In Revision

“Structural Basis of Cooperative COMPASS Activation by Histone Acetylation and Ubiquitination” 

2025

29. Robert J. Fisher, Kihyun Park, Kwangwoon Lee, Katarina Pinjusic, Allison Vanasse, Christina S. Ennis, Parisa Farokh, Scott B. Ficarro, Jarrod A. Marto, Hanjie Jiang, Eunju Nam, Stephanie Stransky, Joseph Duke-Cohan, Melis A. Akinci, Anupa Geethadevi, Eric Raabe, Ana Fiszbein, Shadmehr Demehri, Simone Sidoli, Chad W. Hicks, Derin B. Keskin, Catherine J. Wu, Philip A. Cole, Rhoda M. Alani* JCI Insight 2025, In Press.

    "CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity"

28. Mingeun Kim, Yuxi Lin, Eunju Nam, Dong Min Kang, Sungsu Lim, Yun Kyung Kim, Young-Ho Lee,* Mi Hee Lim* Nat. Chem. Biol. 2025, 21, 1709-1718.

"Interactions with Tau's Microtuble-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity"

27. Zhipeng A. Wang, Jonathan Markert, Maheeshi Yapa Abeywardana, Samual D. Whedon, Xinlei Sheng, Eunju Nam, Kwangwoon Lee, Maggie Chen, Amanda Waterbury, Yingming Zhao, Lucas Farnung,* Philip A. Cole* J. Biol. Chem. 2025, 301, 108446.

      “Structural and Enzymatic Plasticity of SIRT6 Deacylase Activity”

26. Megan J.R. Yeo,† Olivia Zhang,† Xiaowen Xie,† Eunju Nam,† N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas Chen, Khanh Nguyen, Hanjie Jiang, Zhipeng Wang, Kwangwoon Lee, Haibin Mao, Stefan A. Harry, Idris Barakat, Mariko Takahashi, Amanda L. Waterbury, Marco Barone, Andrea Mattevi, Steven A. Carr, Namrata D. Udeshi, Liron Bar-Peled, Philip A. Cole, Ralph Mazitschek, Brian B. Liau,* Ning Zheng* Nature 2025, 639, 232-240.

     “UM171 Glues Asymmetric CRL3–HDAC1/2 Assembly to Degrade CoREST Corepressors”

25. Xiaowen Xie,† Olivia Zhang,† Megan J.R. Yeo,† Ceejay Lee,† Ran Tao, Stefan A. Harry, N. Connor Payne, Eunju Nam, Leena Paul, Y. Li, Hui Si Kwok, Hanjie Jiang, Haibin Mao, Jennifer L. Hadley, Hong Lin, Melissa Batts, Pallavi M. Gosavi, Vincenzo D’Angiolella, Philip A. Cole, Ralph Mazitschek, Paul A. Northcott, Ning Zheng,* Brian B. Liau* Nature 2025, 639, 241-249.

     “Converging Mechanism of UM171 and KBTBD4 Neomorphic Cancer Mutations”

24. Chanju Na,† Mingeun Kim,† Gunhee Kim, Yuxi Lin, Young-Ho Lee, Wojciech Bal,* Eunju Nam,* Mi Hee Lim* ACS Chem. Neurosci. 2025, 16, 732-744.

“Distinct Aggregation Behavior of N-terminally Truncated Aβ4-42 over Aβ1-42 in the Presence of Zn(II)”

23.   Kwangwoon Lee, Marco Barone, Amanda L. Waterbury, Hanjie Jiang, Eunju Nam, Sarah E. DuBois-Coyne, Samuel D. Whedon, Zhipeng A. Wang, Jonatan Caroli, Katherine Neal, Brian Ibeabuchi, Zuzer Dhoondia, Mitzi Kuroda, Brian B. Liau, Samuel Beck,* Andrea Mattevi,* Philip A. Cole* Nat. Chem. Biol. 2025, 21, 227-237.

     “Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1”

2024

22. Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han,* Mu-Hyun Baik,* Young-Ho Lee,* 

    Mi Hee Lim* Adv. Sci. 2024, 11, 2307182.

“APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer's Disease”

Note: This paper was highlighted in multiple media and Hot Topic "Amyloids".

21. Samuel D. Whedon,† Kwangwoon Lee,† Zhipeng A, Wang,† Emily Zahn, Congcong Lu, Maheeshi Yapa-Abeywardana, Louise Fairall, Eunju Nam, Sarah Dubois- Coyne, Pablo De Ioannes, Xinlei Sheng, Adelina Andrei, Emily Lundberg, Jennifer Jiang, Karim-Jean Armache, Yingming Zhao, John W. R. Schwabe, Mingxuan Wu,* Benjamin A. Garcia,* Philip A. Cole* J. Am. Chem. Soc. 2024, 146, 33914-33927.

      “Circular Engineered Sortase for Interrogating Histone H3 in Chromatin”

20. Jong-Min Suh, Wooyeol Ryu, Eunju Nam, Nam Kwon, Kyungmin Kim, Dongwook Kim, Jaeheung Cho,* Kiyoung Park,* Mi Hee Lim* ACS Catal. 2024, 14, 

14497-14508.

      “Dual O2-Mediated Reactivity of a Mononuclear Cobalt Complex with Amyloid-β Peptides”

19. Maheeshi Yapa Abeywardana, Samuel D. Whedon, Kwangwoon Lee, Eunju Nam, Rafael Dovarganes, Sarah Dubois-Coyne, Zhipeng A. Wang,* Philip A. Cole* 

J. Biol. Chem. 2024, 300, 107722.

      “Multifaceted regulation of Sirtuin 2 (Sirt2) Deacetylase Activity”

2023

18. Zhi Du,† Eunju Nam,† Yuxi Lin,† Mannkyu Hong, Tamás Molnár, Ikufumi Kondo, Koichiro Ishimori, Mu-Hyun Baik, Young-Ho Lee,* Mi Hee Lim* Chem. Sci. 2023, 14, 

    5340-5349.

“Unveiling the Impact of Oxidation-driven Endogenous Protein Interactions on the Dynamics of Amyloid-β Aggregation and Toxicity”

  Note: This paper was selected as a "WeChat Promotion Article" and an article for the 2023 Chemical Science HOT Article Collection.

2022

17.   Jiyeon Han, Jeongcheol Shin, Jiwon Yoon, Eunju Nam, Tongrui Qian, Yulong Li, Kiyoung Park,* Seung-Hee Lee,* Mi Hee Lim* Nat. Chem. 2022, 14, 1021-1030.     

“Conformational and Functional Changes of the Native Neuropeptide Somatostatin Occur in the Presence of Copper and Amyloid-β”

  Note: This paper was highlighted in multiple media.

2021

16. Eunju Nam, Jiyeon Han, Sunhee Choi, Mi Hee Lim* Chem. Commun. 2021, 57, 7637-7640.

        “Distinct Impact of Glycation towards the Aggregation and Toxicity of Murine and Human Amyloid-β”

         Note: This paper was contributed to the Special Issue of "Multimolecular Crowding in Biosystems" and selected as “HOT Article” from the Chemical Communication.

2020

15. Eunju Nam, Geewoo Nam, Mi Hee Lim* Biochemistry 2020, 59, 15-17.

        “Synaptic Copper, Amyloid-β, and Neurotransmitters in Alzheimer’s Disease”

        Note: This paper was contributed to the Special Issue of "The Future of Biochemistry: The Asia-Pacific Issue".

2019

14. Mingeun Kim,† Juhye Kang,† Misun Lee,† Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Jiyong Park, Soo jin Oh, Ji-Yoon, Lee, Joo-Yong Lee,* Mu-Hyun Baik,* Mi Hee Lim* J. Am. Chem. Soc. 2020, 142, 8183-8193.

 “Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia”

Note: This paper was selected as an “ACS Editors' Choice”, highlighted in multiple media, and awarded as the “2020 Domestic Bio-field Research Achievement and News Top 5 (BRIC)”.

13. Yelim Yi,† Jiyeon Han,† Min Hee Park, Nahye Park, Eunju Nam, Hee Kyung Jin,* Jae-sung Bae,* Mi Hee Lim* Chem. Commun. 2019, 55, 5847-5850.

  "Tunable Regulatory Activities of 1,10-Phenanthroline Derivatives towards Acid Sphingomyelinase and Zn(II)–Amyloid-β"

Note: This paper was featured as the “Front Cover” from Chemical Communication.

2018

12.   Eunju Nam,† Jeffrey S. Derrick,† Seunghee Lee,† Juhye Kang, Jiyeon Han, Shin Jung C. Lee, Su Wol Chung,* Mi Hee Lim* ACS Chem. Neurosci. 2018, 9, 

 2655-2666.

    “Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid‑β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease”

11. Sonam Kim,† Hyuck Jin Lee,† Eunju Nam,† Donghyun Jeong, Jaeheung Cho,* Mi Hee Lim,* Youngmin You* ACS Omega 2018, 3, 5141-5154.

    “Tailoring Hydrophobic Interactions between Probes and Amyloid-b Peptides for Fluorescent Monitoring Amyloid-β Aggregation”

10. Eunju Nam,† Jiyeon Han,† Jong-Min Suh, Yelim Yi, Mi Hee Lim* Curr. Opin. Chem. Biol. 2018, 43, 8-14.

  “Link of Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons”

2017

9.  Shin Jung C. Lee,† Eunju Nam,† Hyuck Jin Lee, Masha G. Savelieff, Mi Hee Lim* Chem. Soc. Rev. 2017, 46, 310-323.

    “Towards an Understanding of Amyloid-β Oligomers: Characterization, Toxicity Mechanisms, and Inhibitors”

8. Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim, Cheal Kim,* Roger G. Harrison* Spectrochim. Acta A Mol. Biomol. Spectrosc. 2017, 178, 203-211.

 “A Zinc Fluorescent Sensor Used to Detect Mercury(II) and Hydrosulfide”

7. Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim,* Cheal Kim* Sens. Actuators B Chem. 2017, 244, 1045-1053.

          “A Highly Selective Turn-on Chemosensor for Zn(II) in Aqueous Media and Living Cells”

6.   Jeffrey S. Derrick, Jiwan Lee, Shin Jung C. Lee, Yujeong Kim, Eunju Nam, Hyeonwoo Tak, Juhye Kang, Misun Lee, Sunhee Kim,* Kiyoung Park,* Jaeheung Cho,* 

        Mi Hee Lim* J. Am. Chem. Soc. 2017, 139, 2234-2244.

    “Mechanistic Insights into Tunable Metal-mediated Hydrolysis of Amyloid-β Peptides”

 Note: This paper was selected as “Front Cover” and “Spotlights” from Journal of the American Chemical Society.

2016

5. Tae Geun Jo, Jae Jun Lee, Eunju Nam, Kwon Hee Bok, Mi Hee Lim* Cheal Kim* New J. Chem. 2016, 40, 8918-8927.

    “A Highly Selective Fluorescent Sensor for the Detection of Al(III) and CN− in Aqueous Solution: Biological Applications and DFT Calculations”

4.   Jeffrey S. Derrick, Richard A. Kerr, Kyle J. Korshavn, Michael McLane, Juhye Kang, Eunju Nam, Ayyalusamy Ramamoorthy,* Brandon T. Ruotolo,* Mi Hee Lim* 

Inorg. Chem. 2016, 55, 5000-5013.

“The Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease”

3. Jong-Seok Park, Eunju Nam, Hye-Kyeong Lee, Mi Hee Lim,* Hyun-Woo Rhee* ACS Chem. Biol. 2016, 11, 2177-2185.

“In Cellulo Mapping of Subcellular Localized Bilirubin”

Note: This paper was selected by F1000. 

2. Ye Won Choi, Jae Jun Lee, Eunju Nam, Mi Hee Lim, Cheal Kim* Tetrahedron 2016, 72, 1998-2005.

“A Fluorescent Chemosensor for Al(III) Based on Julolidine and Tryptophan Moieties”

1. Jae Jun Lee, Yong Sung Kim, Eunju Nam, Sun Young Lee, Mi Hee Lim,* Cheal Kim* Dalton Trans. 2016, 45, 5700-5712.

“A PET-based Fluorometric Chemosensor for Determination of Mercury(II) and pH, and Hydrolysis Reaction-based Colorimetric Detection of Hydrogen Sulfide”