SELECTED PUBLICATIONS

*denotes equal contributor, #denotes corresponding author, underline denotes Long Lab members 

2025

• Xiao X*, Wu W*, ...Wang J, ... Zhao H#, Long E#, Wang J#. Single-cell Transcriptomic Profiling Reveals Cell-type Heterogenetity between HFpEF and HFrEF. Communications Biology 2025 (Accepted in Principle)

• Ni X*#, Chen T*, Long Y, Li Y, Zhang Z, Long E#. Centenarians: a model of immune resilience against multimorbidity. Life Medicine 2025 (Accepted)

• Long E*#, William J*, ..., Choi J#. An evolving understanding of multiple causal variants underlying genetic association signals. American Journal of Human Genetics 2025

• Sun X*, Tang W*, Huang Z, Long E#, Wan P#. From General to Specific: Tailoring Large Language Models for Real-World Medical Communications. Clinical and Translational Medicine 2025

2024

• Long E*, Yin J*, Shin JH*, Li Y*, ...Sun X, Wang C, ...Lee JG#, Kim EY#, Choi J#. Context-aware single-cell multiomics approach identified cell-type specific lung cancer susceptibility genes. Nature Communications 2024 (Editor Highlights)

• Wan P*, Huang Z*, Tang W, ..., Chen Q#, Long E#. Outpatient reception via collaboration between nurses and a large language model: a randomized controlled trial. Nature Medicine 2024 (Highlighted by Nature Medicine, 'Improving primary healthcare with generative AI')

• Long E*#, Patel H*, …, Choi J#. High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility. American Journal of Human Genetics 2024

• Ni X#, …, Yang Z#, Hu C#. Specific differences and novel key regulatory genes of sex in influencing exceptional longevity phenotypes. Diabetes Metab Syndr. 2024

2023

• Long E, Zhang J#. Evidence for the role of selection for reproductively advantageous alleles in human aging. Science Advances 2023 (Highlighted by The New York Times, 'Genes That Boost Fertility Also Shorten Our Life, Study Suggests')

• Long E*#, Wan P*, Chen Q, Lu Z, Choi J#. From function to translation: decoding genetic susceptibility to human diseases via artificial intelligence. Cell Genomics 2023

2022

• Long E*, Yin J*, Funderburk K, …, Choi J#. Massively parallel reporter assays with variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity. American Journal of Human Genetics 2022 (Highlighted by American Journal of Human Genetics, ‘Paving a post-GWAS pathway’)

• Long E,…, Amos CI#, Choi J#. Functional Studies of Lung Cancer GWAS beyond Association. Human Molecular Genetics 2022

• Long E,…, Choi J#. The case for increasing diversity in tissue-based functional genomics datasets to understand human disease susceptibility. Nature Communications 2022

• Wang W#, Gao X#, Zhu Y#, Long E#. Computational Medicine in Visual Impairment and Its Related Disorders. Frontiers in Medicine 2022

• Byun J*, Han Y*, Li Y*, Xia J*, Long E*, Choi J, …, Amos CI#. Trans-ancestry genome-wide meta-analysis of 60,290 cases and 896,712 controls identifies novel genomic cross-ancestry loci contributing to lung cancer susceptibility. Nature Genetics 2022 (Highlighted by Cancer Discovery, ‘Cross-ancestry Genomic Data Reveal New Susceptibility Loci in Lung Cancer’)

• Wan P,…, Long E#, Zhuo Y#. Reciprocal regulation between lncRNA ANRIL and p15 in steroid-induced glaucoma. Cells 2022

• Yan J, Wan P, Choksi S, Liu ZG#. Necroptosis and tumor progression. Trends in Cancer 2022

• Wan P*#, Yan J*, Liu ZG. Methodological advances in necroptosis research: from challenges to solutions. Journal of the National Cancer Center 2022

• Baik JY*, Wan P*, Liu ZG#. Examining MLKL phosphorylation to detect necroptosis in murine mammary tumors. STAR Protocol 2022

2021

• Long E, Zhang J#. Natural selection contributes to the myopia epidemic. National Science Review 2021

• Long E, Wu X#,…, Lin H#. Real-world big data demonstrates population trends and developmental patterns of myopia: A retrospective, multicenter study. Annals of Translational Medicine 2021

• Wan P*, Long E*,…, Zhuo Y#. TET dependent GDF7 hypomethylation impairs intraocular circulation and serves as a potential therapeutic target in glaucoma. Molecular Therapy 2021

2020

• Long E*, Chen J*, Wu X*, Lin Z*, Wang L*, …, Lin H#. Artificial intelligence manages congenital cataracts with individualized prediction and telehealth computing. NPJ Digital Medicine 2020

• Long E, Zhang J#. The coupon collection behavior in human reproduction. Current Biology 2020 (Highlighted by Nature, ‘Parents desire for one boy and one girl pushed trend in family patterns’; Highlighted by Current Biology, 'The Sex Ratio: A Biological and Statistical Conundrum')

• Long E*, Gao X*,…, Lin H#. The Detrimental Effect of Noisy Visual Input on the Visual Development of Human Infants. iScience 2020

• Wan P*,..., Long E, Zhuo Y#. LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury. Cell Death & Differentiation 2020

2019

• Long E, Zhang J#. Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease. Nature Ecology & Evolution 2019

• Long E*, Lin Z*, Xiang Y*,…, Lin H#, Liu Y#. Discrimination of the behavioural dynamics of visually impaired infants via deep learning. Nature Biomedical Engineering 2019 (Cover Highlights)

2018

• Lin H*, Long E*,…, Liu Y#. Prediction of myopia development among Chinese school-aged children using refraction data from electronic medical records: A retrospective, multicentre machine learning study. PLoS Medicine 2018

• Wan P, Long E#. Pollution Control for a Healthier Chinese Population. Lancet Planetary Health 2018.

• Long E#. Evolutionary medicine: Why does prevalence of myopia significantly increase? Evolution, Medicine, Public Health 2018

• Wan P, Long E#. Use of a Neural Net to Model the Impact of Optical Coherence Tomography Abnormalities on Vision in Age-related Macular Degeneration. American Journal of Ophthalmology 2018

2017

• Long E*, Lin H*#,…, Liu Y#. An artificial intelligence platform for the multihospital collaborative management of congenital cataracts. Nature Biomedical Engineering 2017 (Cover Highlights)

• Long E, Wan P#, Zhuo Y. Predicting the Real-World Future of Glaucoma Patients? Cautions Are Required for Machine Learning. Translational Vision Science & Technology 2017

• Long E,…, Cai J#, Lin H#. Construction and implications of structural equation modeling network for pediatric cataract: a data mining research of rare diseases. BMC Ophthalmology 2017

• Long E*, Lin Z*, Chen J*,…, Lin H#. Monitoring and Morphologic Classification of Pediatric Cataract Using Slit-Lamp-Adapted Photography. Translational Vision Science & Technology 2017

• Long E*, Zhang X*,…, Lin H#. Dynamic response to initial stage blindness in visual system development. Clinical Science 2017 (Cover Highlights)

• Long E, Wan P#, Zhuo Y. Comment on 'Visual acuity and its predictors after surgery for bilateral cataracts in children'. Eye 2017

• Wan P,..., Zhuo Y#. Trimetazidine protects retinal ganglion cells from acute glaucoma via the Nrf2/Ho-1 pathway. Clinical Science 2017 (Cover Highlights)

• Wan P, Su W#, Zhuo Y#. Precise long non-coding RNA modulation in visual maintenance and impairment. Journal of Medical Genetics 2017

• Wan P, Su W#, Zhuo Y#. The Role of Long Noncoding RNAs in Neurodegenerative Diseases. Molecular Neurobiology 2017

2016

• Wan P, Long E#. Expectations of medical students in China. Lancet 2016

2015

• Lin H, Long E, Chen W, Liu Y#. Documenting rare disease data in China. Science 2015

2014

• Yang F*, Long E*, Wen J*, Cao L*,…, Wu Z#, Lv Z#. Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum. Parasite & Vectors 2014