Scroll down to the bottom or check Google Scholar for a full publication list.
(Below are selected ones with brief description)
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Nature 2025, https://doi.org/10.1038/s41586-025-09417-w
Nature 2025, https://doi.org/10.1038/s41586-025-09417-w
We introduced a genetically encodable protein spin qubit based on yellow fluoresence protein (YFP).
(Artwork by Peter Allen, Second Bay Studios)
Nature Protocols 2025, https://doi.org/10.1038/s41596-025-01177-1
Nature Protocols 2025, https://doi.org/10.1038/s41596-025-01177-1
This is a comprehensive protocol providing extensive details about performing NASR experiment -- a simple yet powerful solution NMR technique allowing quantitative detection of protein internal dynamics on the ns-μs timescales, a range that many loop motions fall in.
Nature Communications 2024, 15, 8788
Nature Communications 2024, 15, 8788
Combining material engineering and quantum technologies, we managed to fabricate high-quality diamond membrane heterostructures as thin as 10 nm to be unique platforms for nanophotonics and quantum biosensing applications. In this movie, bacteria expressing green fluorescence protein are swimming near a diamond membrane, which contains nitrogen-vacancy spin qubit sensors.
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119, e2114186119
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119, e2114186119
We developed a biocompatible, versatile, stable, and recyclable surface functionalization method to place biomolecules of interest to the surface of a diamond quantum sensor, which is the first step toward realization of single-molecule quantum biosensing.
Highlighted by Nat. Rev. Mater.
Science Advances, 2019, 5, eaax5560
Science Advances, 2019, 5, eaax5560
In this study, we developed a nanoparticle-assisted detection approach based on NMR spin relaxation, which expands the observation window of intrinsic protein motions from traditional nanosecond regime to microsecond regime. It will allow us to explore protein functionalities that are previously unknown.
Journal of American Chemistry Society, 2020, 142, 10730.
Journal of American Chemistry Society, 2020, 142, 10730.
We developed a quantitative binding model, named SILC, which describes the dual role that residues play in intrinsically disordered proteins simultaneously as linkers and ligands when interact with nanomaterials or other biomolecules. The SILC model is based on first principle statistical mechanics and explicitly includes cooperativity effects in a fully analytical manner.
Journal of Physical Chemistry Letters, 2020, 11, 10401
Journal of Physical Chemistry Letters, 2020, 11, 10401
We discovered and systematically studied the "silica-philic" propensity of N-methyl motif. This motif is common to many biological molecules including nucleosides that control the flow of genetic information as a form of epigenetic modification.
Full publication list
Full publication list
* Equal contributions; ^ Correspondence
16. J.S. Feder*, B.S. Soloway*, S. Verma, Z.Z. Geng, S. Wang, B.B. Kifle, E.G. Riendeau, Y. Tsaturyan, L.R. Weiss, M. Xie, J. Huang, A. Esser-Kahn, L. Gagliardi, D.D. Awschalom^ & P.C. Maurer^. "A fluorescent-protein spin qubit" Nature. 2025, https://www.nature.com/articles/s41586-025-09417-w.
15. X. Xiang, A.L. Hansen, L. Bruschweiler-Li, R. Brüschweiler^ & M. Xie^. "Detection of intramolecular protein dynamics on nanosecond-to-microsecond timescales by nanoparticle-assisted NMR spin relaxation (NASR)" Nature Protocols. 2025, https://doi.org/10.1038/s41596-025-01177-1. A complimentary view-only copy is provided by the publishing house at https://rdcu.be/evmDs.
14. X. Guo, M. Xie*, A. Addhya*, A. Linder*, U. Zvi, T.D. Deshmukh, Y. Liu, I.N. Hammock, Z. Li, C.T. DeVault, A. Butcher, A.P. Esser-Kahn, D.D. Awschalom, N. Delegan, P.C. Maurer, F.J. Heremans & A.A. High^. "Direct-bonded diamond membranes for heterogeneous quantum and electronic technologies" Nature Communications. 2024, 15, 8788.
### Prior to ASU ###
13. M. Xie*, X. Yu*, L.V.H. Rodgers, D. Xu, I. Chi-Durán, A. Toros, N. Quack, N.P. de Leon & P.C. Maurer^. "Biocompatible surface functionalization architecture for a diamond quantum sensor" Proceedings of the National Academy of Sciences of the United States of America, 2022, 119, e2114186119. An authors' copy is on arXiv.
12. L.V.H. Rodgers, L.B. Hughes, M. Xie, P.C. Maurer, S. Kolkowitz, A.C. Bleszynski Jayich & N.P. de Leon^. "Materials challenges for quantum technologies based on color centers in diamond" MRS Bulletin, 2021, 46, 623. [Invited review] A complimentary view-only copy is provided by the publishing house at https://rdcu.be/ctXz8. An authors' copy is on arXiv.
11. M. Xie^ & R. Brüschweiler^. "Degree of N-methylation of nucleosides and metabolites controls binding affinity to pristine silica surfaces" Journal of Physical Chemistry Letters, 2020, 11, 10401.
10. S. Wardenfelt*, X. Xiang*, M. Xie*, L. Yu, L. Bruschweiler-Li & R. Brüschweiler^. “Broadband dynamics of ubiquitin by anionic and cationic nanoparticle-assisted NMR spin relaxation" Angewandte Chemie International Edition, 2020, 60, 148.
9. D.-W. Li^, M. Xie & R. Brüschweiler^. “Quantitative cooperative binding model for intrinsically disordered proteins interacting with nanomaterials” Journal of American Chemistry Society, 2020, 142, 10730.
8. M. Xie*, L. Yu*, L. Bruschweiler-Li, X. Xiang, A.L. Hansen & R. Brüschweiler^. “Functional protein dynamics on uncharted timescales detected by nanoparticle-assisted NMR spin relaxation” Science Advances, 2019, 5, eaax5560.
7. M. Xie, D.-W. Li, J. Yuan, A.L. Hansen & R. Brüschweiler^. “Quantitative binding behavior of intrinsically disordered proteins to nanoparticle surfaces at individual residue level” Chemistry-A European Journal 2018, 24, 16997.
6. J. Yuan, C. Yuan, M. Xie, L. Yu, L. Bruschweiler-Li & R. Brüschweiler^. “The intracellular loop of the Na+/Ca2+ exchanger contains an “awareness ribbon”-shaped two-helix bundle domain” Biochemistry 2018, 57, 5096.
5. B. Zhang^, M. Xie, L. Bruschweiler-Li & R. Brüschweiler^. “Nanoparticle-assisted metabolomics” Metabolites 2018, 8, 21. [Invited review]
4. M. Xie, A.L. Hansen, J. Yuan & R. Brüschweiler^. “Residue-specific interactions of an intrinsically disordered protein with silica nanoparticles and their quantitative prediction” The Journal of Physical Chemistry C 2016, 120, 24463.
3. A.K. Bingol, L. Bruschweiler-Li, D.-W. Li, B. Zhang, M. Xie & R. Brüschweiler^. “Emerging new strategies for successful metabolite identification in metabolomics” Bioanalysis 2016, 8, 557. [Invited review]
2. B. Zhang, M. Xie, L. Bruschweiler-Li & R. Brüschweiler^. “Nanoparticle-assisted removal of protein in human serum for metabolomics studies” Analytical Chemistry 2016, 88, 1003.
1. B. Zhang*, M. Xie*, L. Bruschweiler-Li, A.K. Bingol & R. Brüschweiler^. “Use of charged nanoparticles in NMR-based metabolomics for spectral simplification and improved metabolite identification” Analytical Chemistry 2015, 87, 7211. [Selected as one of the 28 papers in ACS virtual issue “NMR Developments and Application”. Analytical Chemistry 2017, 89, 1391]
Ph.D. Dissertation
Probing and modeling of biomolecule-nanoparticle interactions by NMR spectroscopy. The Ohio State University. 2018.
Last update: Nov. 2025
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