Agenda

Day 1

26.05.2021

14:00–14:20 CET Berlin
08:00–08:20 am EDT Boston

Welcome and Introduction Epithelioid Sarcoma Digital Expert Panel 2021

Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany, Paolo Casali, Istituto Nazionale Tumori, Italy, Andrea Bolzicco, Orchestra per la Vita, Italy, Michael Wortmann, SMARCB1 e.V., Germany

14:20–15:40 CET Berlin
08:20–09:40 am EDT Boston

Presentations (10-15 min.) & Discussion (10-15 min.).
Moderation Thomas Grünewald

From Enzinger to WHO 2020, fifty years of epithelioid sarcoma diagnoses
Angelo Paolo Dei Tos, Istituto Nazionale Tumori, Italy

Epithelioid Sarcoma: Epidemiology and registry

Annalisa Trama, Istituto Nazionale dei Tumori, Milan, Italy

Natural history and prognostic of epithelioid sarcoma: what is known and what is left to know
Anna Maria Frezza, Istituto Nazionale dei Tumori, Milan, Italy

The proteomic landscape of SMARCB1-deficient sarcomas
Paul Huang, The Institute of Cancer Research, United Kingdom

Break 15:40–15:55 CET Berlin
09:40–09:55 am EDT Boston

15:55–16:55 CET Berlin
09:55–10:55 am EDT Boston

Presentations (10-15 min.) & Discussion (10-15 min.).
Moderation Paolo Casali

Functional and translational genomics of epithelioid sarcoma
Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany

Novel Pipeline for Precision Immunotherapy
Vincezo Cerullo, ImmunoViroTherapy Lab, University of Helsinki, Finland

Immunomodulation approach for Epithelioid Sarcoma
Javier Martin-Broto, MUsculoSkeletal Tumor Board of Excellence Sevilla (MUSTBE SEVILLA), Instituto de Biomedicina de Sevilla, Spain

Break 16:55–17:10 CET Berlin
10:55–11:10 EDT Boston

17:10–17:50 CET Berlin
11:10–11:50 am EDT Boston

Presentations (10-15 min.) & Discussion (10-15 min.).
Moderation Thomas Grünewald

Novel multitarget inhibitors in Epithelioid Sarcoma treatment: an in vitro preliminary study
Alessandro Sgambato, Centro di Riferimento Oncologico della Basilicata (CROB), Italy

May we target sarcoma metastasis with immunotherapy?
Antonio Perez-Martinez, Hospital La Paz Institute for Health Research (IdiPAZ), Spain

17:50–18:20 CET Berlin
11:50 am –12:20 pm EDT Boston

Discussion “Future strategy against Epithelioid Sarcoma”
Moderation Thomas Grünewald / Paolo Casali

▪ Which questions are unresolved and need to be answered urgently (biology and therapy)?
▪ How can basic research and clinical research be linked? (knowledge transfer)
▪ Which other disciplines need to be involved?

18:20-19:00 CET Berlin
12:20–01:00 pm EDT Boston

Digital getTogehter

Available Rooms with specific Topics:
▪ "Immunotherapy“ with Vincenzo Cerullo, University of Helsinki
▪ Further Rooms to be announced

End of Event 19:00 CET Berlin
01:00 pm EDT Boston



Day 2

27.05.2021

14:00–14:20 CET Berlin
08:00–08:20 am EDT Boston

Welcome and Introduction Epithelioid Sarcoma Digital Expert Panel 2021

Paolo Casali, Director of the Medical Oncology Unit 2 at the Istituto Nazionale Tumori, Milan, Italy, Thomas Grünewald, Head of Dept. Translational Pediatric Sarcoma Research, German Cancer Research Center DKFZ / Hopp-Kindertumorzentrum (KiTZ) Heidelberg, Germany Andrea Bolzicco, Orchestra per la Vita, Italy, Michael Wortmann, SMARCB1 e.V., Germany

14:20–15:40 CET Berlin
08:15–09:40 am EDT Boston

Presentations (10-15 min.) & Discussion (10-15 min.).
Moderation Paolo Casali

Challenges in Epitheloid Sarcoma - Along with developing countries perspective
Sameer Rastogi, All India Institute of Medical Sciences, India

Systemic treatments in the advanced disease
Silvia Stacchiotti, Istituto Nazionale dei Tumori, Milan, Italy

Localized epithelioid sarcoma: should we tailor the surgical strategy to the histologic subtype?
Alessandro Gronchi, Istituto Nazionale dei Tumori, Milan, Italy

Photodynamic therapy of sarcomas
Nicola Baldini, IRCCS Istitute Ortopedico Rizzoli, Italy

Break 15:00–15:55 CET Berlin
09:40–09:55 am EDT Boston

15:55–17:15 CET Berlin
09:55–11:15 am EDT Boston

Presentations (10-15 min.) & Discussion (10-15 min.).
Moderation Thomas Grünewald

The real-world treatment patterns and outcomes of patients with locally advanced or metastatic epithelioid sarcoma
Anna Czarnecka, Maria Sklodowska-Curie National Research Institute of Oncology, Poland

Structure and function of mammalian SWI/SNF chromatin remodeling complxes in human cancer
Cigall Kadoch, Kadoch LAB, Dana-Farber Cancer Institute, Harvard Medical School, USA

Immunotherapy and Sarcoma
Andrew Pecora, John Theurer Cancer Center, Hackensack University Medical Center, USA

The functional genomic landscape of Epithelioid Sarcoma
Charles Keller, Children’s Cancer Therapy Development Institute, USA

Break 17:15–17:30 CET Berlin
11:15–11:30 am EDT Boston

17:30–18:00 CET Berlin
11:30 am–12:00 pm EDT Boston

Discussion “Future strategy against Epithelioid Sarcoma”
Moderation Thomas Grünewald / Paolo Casali

▪ How can basic research and clinical research be linked? (knowledge transfer)
▪ Which other disciplines need to be involved?
▪ Organization/coordination of research management

18:00–18:30 CET Berlin
12:00–12:30 pm EDT Boston

Discussion "Establishment of a working group Epithelioid Sarcoma "
Moderation Paolo Casali / Thomas Grünewald

▪ Goal of regular meetings and knowledge exchange
▪ Tasks and goals result from the formulation of the future strategy
▪ Organization/coordination/financing
▪ Takeaway and Deliverables of EPS 2021 Meeting / Next Steps

18:30-19:00 CET Berlin
12:30–01:00 pm EDT Boston

Digital getTogehter

Available Rooms with specific Topics:
▪ "Innovation and Technology for EPS Cures“ with Charles Keller, Children’s Cancer Therapy Development Institute
▪ Further Rooms to be announced

End of Event 18:30 CET Berlin
01:00 pm EDT Boston