Publications

Next generation risk assessment of biocides (PHMG-p and CMIT/MIT)-induced pulmonary fibrosis using adverse outcome pathway-based transcriptome analysis. JW Kim, HS Kim, HR Kim, KH Chung. (2024) J Hazard Mater, 476, 134986. 

Anti-inflammatory lignan and triterpenoid compounds from the twigs of Ligustrum lucidum. DH Sim, NK Vu, DD Le, HR Kim, ES Ma, BS Min, MH Woo. (2023) Phytochemistry Letters, 54, 1-6. 

Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells. MS Jeon, JW Kim, YB Han, MH Jeong, HR Kim, HS Kim, YJ Park, KH Chung. (2023) Environmental Toxicology, 38(2), 359-367. 

A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate. M Kim, S Hur, KH Kim, Y Cho, K Kim, HR Kim, KT Nam, KM Lim. (2022) Biomolecules & Therapeutics, 30(2), 126.

Reprogrammed lung epithelial cells by decrease of miR-451a in extracellular vesicles contribute to aggravation of pulmonary fibrosis. MH Jeong, HR Kim, YJ Park, KH Chung, HS Kim. (2022) Cell Biology and Toxicology, 38(5), 725-740.

Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat cerebrovascular endothelium. D Kim, Y Shin, EH Kim, Y Lee, S Kim, HS Kim, HC Kim, JH Leem, HR Kim, ON Bae. (2022) Toxicology Letters, 366, 45-57. 

Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition. YJ Park, DM Kim, HB Choi, MH Jeong, SH Kwon, HR Kim, JH Kwak, KH Chung. (2022) Nutrients, 14(1), 98.

Comparison of 3D airway models for the assessment of fibrogenic chemicals. JW Kim, MH Jeong, GE Kim, Y Han, YJ Park, KH Chung, HR Kim. (2022) Toxicology Letters, 356, 100-109.

Liposome leakage and increased cellular permeability induced by guanidine-based oligomers: effects of liposome composition on liposome leakage and human lung epithelial barrier permeability. Y Ha, Y Koo, SK Park, GE Kim, HB Oh, HR Kim, JH KWON. (2021) RSC advances, 11, 32000-32011.

Novel QSAR Models for Molecular Initiating Event Modeling in Two Intersecting Adverse Outcome Pathways Based Pulmonary Fibrosis Prediction for Biocidal Mixtures. M Seo, CH Chae, Y Lee, HR Kim, JW Kim. (2021) Toxics, 9(3), 59.

Pre-validation of a Calu-3 epithelium cytotoxicity assay for predicting acute inhalation toxicity of chemicals. MH Jeong, Y Han, IS Oh, DM Kim, DW Son, MS Jung, H Yang, K Lee, JY Shin, HR Kim, KH Chung. (2021) Toxicology in Vitro, 75, 105136.

Polyhexamethylene guanidine phosphate induces apoptosis through endoplasmic reticulum stress in lung epithelial cells. MH Jeong, MS Jeon, GE Kim, HR Kim. (2021) International Journal of Molecular Science, 22(3), 1215.

Prediction of acute inhalation toxicity using cytotoxicity data from human lung epithelial cell lines. SK Lim, J Yoo, H Kim, YM Lim, W Kim, I Shim, HR Kim, P Kim, I Eom. (2021) Journal of Applied Toxicology, 41(7), 1038-1049.

(-)-Catechin-7-O-β-d-apiofuranoside inhibits hepatic stellate cell activation by suppressing the STAT3 signaling pathway. YJ Park, DM Kim, MH Jeong, JS Yu, HM So, IJ Bang, HR Kim, SH Kwon, KH Kim, KH Chung. (2020) Cells, 9(1), 1-17.

Establishment study on quality and toxicity testing of respiratory 3D tissue model (SoluAirway) in Korea. MH Jeong, SY Kim, JW Kim, IJ Bang, GE Kim, HS Kim, SH Lee, HR Kim. (2019) Journal of Alternatives to Animal Experiments, 13(1), 17-23.

Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2. MH Jeong, HR Kim, YJ Park, KH Chung. (2019) Toxicology and Applied Pharmacology, 380, 114691.

Effects of β-sitosterol from corn silk on TGF-β1-induced epithelial-mesenchymal transition in lung alveolar epithelial cells. YJ Park, IJ Bang, MH Jeong, HR Kim, DE Lee, JH Kwak, KH Chung. (2019) Journal of Agricultural and Food Chemistry, 67, 9789-9795.

In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay. MH Jeong, HR Kim, IJ Bang, SH Yoo, SJ Lee, KH Lee, KH Chung. (2019) Journal of Pharmacological and Toxicological Methods, 98, 106576.

PHMG-p, PHMB, and PGH induced epithelial-mesenchymal transition in A549 alveolar epithelial cells. YJ Park, MH Jeong, IJ Bang, HR Kim, KH Chung. (2019) Inhalation Toxicology, 31(4), 161-166.

Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells. JS Park, YJ Park, HR Kim, KH Chung. (2019) Journal of Toxicological Sciences, 44(6), 415-424.

Polyhexamethylene guanidine phosphate-induced upregulation of MUC5AC via activation of the TLR-p38 MAPK and JNK axis. MH Jeong, YJ Park, HR Kim, KH Chung. (2019) Chemico-Biological Interactions, 305, 119-126.

β-peltoboykinolic acid from Astilbe rubra attenuates TGF-β1-induced epithelial-to-mesenchymal transitions in lung alveolar epithelial cells. IJ Bang, HR Kim, Y Jeon, MH Jeong, YJ Park, JH Kwak, KH Chung. (2019) Molecules, 24(14), 2573.

A review of current studies on cellular and molecular mechanisms underlying pulmonary fibrosis induced by chemicals. HR Kim, DY Shin, KH Chung. (2018) Environmental Analysis Health and Toxicology, 33(3), 1-7.

MicroRNA regulatory networks reflective of polyhexamethylene guanidine phosphate-induced fibrosis in A549 human alveolar adenocarcinoma cells. DY Shin, MH Jeong, IJ Bang, HR Kim, KH Chung. (2018) Toxicology Letters, 287, 49-58.

Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson’s disease model. SM Kim, YJ Park, MS Shin, HR Kim, MJ Kim, SH Lee, SP Yun, SH Kwon. (2017) Bioorganic & Medicinal Chemistry Letters, 27(23), 5207-5212.

In vitro inflammatory effects of polyhexamethylene biguanide through NF-ĸB activation in A549 cells. HR Kim, DY Shin, KH Chung. (2017) Toxicology In Vitro, 38, 1-7.

Novel approach to study the cardiovascular effects and mechanism of action of urban particulate matter using lung epithelial-endothelial tetra-culture system. HR Kim, HS Cho, DY Shin, KH Chung. (2017) Toxicology In Vitro, 38, 33-40.

Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate. HR Kim, GW Hwang, A Naganuma, KH Chung. (2016) Journal of Toxicological Sciences, 41(6), 711-717.

Occurence of health damage by humidifier disinfectant in Korea. GW Hwang, HR Kim, A Naganuma, KH Chung. (2016) Toxicology News, 41(5), 96-102.

Inhibitory effect of Sphagnumpalustre extract and its bioactive compounds on aromatase activity. HJ Eom, YJ Park, HR Kang, HR Kim, IJ Bang, HB Park, KH Chung, KH Kim. (2016) Bangladesh Journal of Pharmacology. 11(3), 1730-1733.

Polyhexamehtylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses. HR Kim, KH Lee, CW Park, JA Song, DY Shin, YJ Park, KH Chung. (2016) Archives of Toxicology, 90(3), 617-632.

Ginkgo biloba extract EGb761-mediated inhibition of aromatase for the treatment of hormone-dependent breast cancer. YJ Park, HY Ahn, HR Kim, KH Chung, SM Oh. (2016) Food and Chemical Toxicology, 87, 157-165.

Inhibitory aromatase effects of flavonoids from Ginkgo biloba extracts on estrogen biosynthesis. YJ Park, WH Choo, HR Kim, KH Chung, SM Oh. (2015) Asian Pacific Journal of Cancer Prevention, 16(15), 6317-6325.

Ethanolic extract of dandelion (Taraxacum mongolicum) induces estrogenic activity in MCF-7 cells and immature rats. SM Oh, HR Kim, YJ Park, YH Lee, KH Chung. (2015) Chinese Journal of Natural Medicines, 13(11), 808-814.

The role of NF-ĸB signaling pathway in polyhexamethylene guanidine phosphate induced inflammatory response in mouse macrophage RAW264.7 cells. HR Kim, DY Shin, KH Chung. (2015) Toxicology Letters, 233(2), 148-155.

Comparative evaluation of the mutagenicity and sgenotoxicity of smoke condensate derived from Korean cigarettes. HR Kim, JE Lee, MH Jeong, SJ Choi, KH Lee, KH Chung. (2015) Environmental Analysis Health and Toxicology, 30, 1-7.

Developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in artificially fertilized crucian carp (Carassius auratus) embryo. YJ Park, MJ Lee, HR Kim, KH Chung, SM Oh. (2014) Science of the Total Environment, 491-492, 271-278.

Silver nanoparticles induce p53-mediated apoptosis in human brochial epithelial (BEAS-2B) cells. HR Kim, DY Shin, YJ Park, CW Park, SM Oh, KH Chung. (2014) Journal of Toxicological Sciences, 39(3), 401-412.

Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells. HR Kim, MH Jung, SY Lee, SM Oh, KH Chung.  (2013) Journal of Toxicological Sciences, 38(3), 337-347.

Chemopreventive effects of Ginkgo biloba extract in estrogen-negative human breast cancer cells. YJ Park, MJ Kim, HR Kim, MS Yi, KH Chung, SM Oh. (2013) Archives of Pharmacal Research, 36(1), 102-108.

Appropriate in vitro methods for genotoxicity testing of silver nanoparticles. HR Kim, YJ Park, DY Shin, SM Oh, KH Chung. (2013) Environmental Analysis Health and Toxicology, 28, 1-8.

The role of p53 in marijuana smoke condensates-induced genotoxicity and apoptosis. HR Kim, BH Son, SH Lee, KH Chung, SM Oh. (2012) Environmental Analysis Health and Toxicology, 27, 1-8.

Genotoxic effects and oxidative stress induced by organic extracts of particulate matter (PM10) collected from a subway tunnel in Seoul, Korea. MH Jung, HR Kim, YJ Park, DS Park, KH Chung, SM Oh. (2012) Mutation Research – Genetic Toxicology and Environmental mutagenesis, 749(1-2), 39-47.

Estrogenic effects and their action mechanism of the major active components of party pill drugs. CR Min, MJ Kim, YJ Park, HR Kim, SY Lee, KH Chung, SM Oh. (2012) Toxicology Letters, 214(3), 339-347.

Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells). SM Oh, HR Kim, YJ Park, SY Lee, KH Chung. (2011) Mutation Research – Genetic Toxicology and Environmental mutagenesis, 723(2), 142-151.

Molecular cloning and characterization of the estrogen receptor from the striped bitterling (Acheilognathus yamatsutae). JG Kim, HR Kim, YJ Park, KH Chung, SM Oh. (2011) Environmental Analysis Health and Toxicology, 26, 1-11.

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells. HR Kim, MJ Kim, SY Lee, SM Oh, KH Chung. (2011) Mutation Research – Genetic Toxicology and Environmental mutagenesis, 726(2), 129-135.

Molecular cloning of vitellogenin gene and mRNA expression by 17alpha-ethinylestradiol from slender bitterling. HR Kim, YJ Park, JG Kim, KH Chung, SM Oh. (2010) General and Comparative Endocrinology, 168(3), 484-495.

Early life stage toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in crucian carp (Carassius auratus). YJ Park, HR Kim, MJ Lee, WO Lee, JS Lee, KH Chung, SM Oh. (2010) Environmental Analysis Health and Toxicology, 25(3), 241-251.

Molecular cloning of CYP1A gene and its expression by benzo(a)pyrene from goldfish (Carassius auratus). SM Oh, BT Ryu, HR Kim, K Choi, KH Chung. (2009) Environmental Toxicology, 24(3), 225-234.

In vitro estrogenic and antiestrogenic potential of chlorostyrenes. SM Oh, HR Kim, KH Chung. (2009) Toxicology In Vitro, 23(7), 1242-1248.

Identification of estrogen-like effects and biologically active compounds in river water using bioassays and chemical analysis. SM Oh, HR Kim, HK Park, K Choi, J Ryu, HS Shin, JS Park, JS Lee, KH Chung. (2009) Science of the Total Environment, 407(21), 5787-5794. 

Early life stage of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in goldfish (Carassius auratus). SM Oh, BT Ryu, HR Kim, KH Chung. (2009) Journal of Environmental Toxicology, 24(1), 1-8.

Effects of ginkgo biloba on in vitro osteoblast cells and ovariectomized rat osteoclast cells. SM Oh, HR Kim, KH Chung. (2008) Archives of Pharmacal Research, 31(2), 216-224.