Molecular & environmental Toxicology Laboratory
Molecular & environmental Toxicology Laboratory
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We Lead the Way in Developing New Approach Methodologies for Regulatory Toxicology.
New Approach Methodologies (NAMs) are an emerging tool in toxicology for performing risk assessment. NAMs reduce animal testing while increasing robustness, throughput and providing a mechanistic understanidng of chemical mode-of-actions, in accordance with the Next Generation Risk Assessment principles. With the mission to educate, lead, and serve professionals in toxicology and related disciplines by promoting the learning of information and perspectives on toxicology and NAMs, We provide you with numerous opportunities to engage in professional education and research.
Development of New Approach Methodologies
Development of New Approach Methodologies
New Approach Methodologies are defined as any technology, methodology, approach, or combination that provide information on chemical hazard and risk assessment without the use of animals, including in silico, in chemico, and in vitro approaches. We study the development of novel in vitro technologies using 3D tissue models and organ-on-a-chip that mimic human organs.
Elucidation of Toxic Mechanisms of Chemicals
Elucidation of Toxic Mechanisms of Chemicals
An adverse outcome pathway (AOP) is a model that identifies the sequence of molecular and cellular events required to produce a toxic effect when an organism is exposed to a substance. AOPs can provide a conceptual basis for non-animal testing strategies. To contribute to the AOP framework, we study the toxic mechanisms of various subtances such as toxicants, E-cigarette, airborne particles, and humidifier disinfectants.
Advancing Risk Assessment
Advancing Risk Assessment
Next Generation Risk Assessment (NGRA) is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates in silico, in chemico, and in vitro approaches. Developing an NGRA not relying on animal data is not only a challenge, but also an opportunity for all involved, to increase receptiveness and acceptance of non-animal data in safety decision making. In this context, we study advanced methodologies of risk assessment.
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