Publications

Peer-Reviewed Manuscripts

1. Sarkar S, Malovic E, Plante B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility. J Vis Exp. 2017 Apr 13;

2. Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. NPJ Parkinsons Dis. 2017 Oct 17(Featured Paper);

3. Sarkar S, Malovic E, Harischandra DS, Ngwa HA, Ghosh A, Hogan C, Rokad D, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. Neurotoxicology. 2018 Jan (Paper of the Year);

4. Sarkar S, Malovic E, Sarda D, Lawana V, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Characterization and comparative analysis of a new mouse microglial cell model for studying neuroinflammatory mechanisms during neurotoxic insults. Neurotoxicology. 2018 Jul;

5. Sarkar S, Rokad DR, Malovic E, Harishchandra DS, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Manganese, an environmental neurotoxin, promotes NLRP3 inflammasome activation in cell culture and animal models of Parkinson's disease. Science Signaling, 2019 Jan (Cover article);

6. Sarkar S, Dammer E, Olsen A, Raza S, Gao T, Oliver D, Duong D, Joers V, Malovic E, Seyfried N, Huang M, Kukar T, Tansey M, Kanthasamy AG, Rangaraju S. Molecular signatures of neuroinflammation induced by α-synuclein aggregates in microglial cells, Frontiers in Immunology, 2020 Jan;

7. Sarkar S, Nguyen H, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal ML, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, Ay M, Charli A, Harishchandra DS, Jin L, Jin, H, Rangaraju S, Anantharam VA, Wulff H, Kanthasamy AG. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease; Journal of Clinical Investigation, 2020 Aug;

8.    Sarkar S, Murphy MA, Dammer EB, Olsen AL, Rangaraju S, Fraenkel E, Feany MB. Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy. NPJ Parkinsons Dis. 2020;6(1):40;

9.    Sarkar S, Olsen AL, Sygnecka K, Lohr K, Feany MB. α-synuclein impairs autophagosome maturation through abnormal actin stabilization. Plos Genetics. 2021 Feb;

10.  Sarkar S, Bardai F, Olsen A, Lohr K, Zhang Y, Feany MB. LRRK2 modification modulates α-synuclein toxicity by actin hyperstabilization, Molecular Neurodegeneration, 2021 May (Featured Paper);

11.  Sarkar S*. Mechanism of gene-environment interactions driving glial activation in Parkinson's disease. Current Environmental Health Reports, 2021 May;

12.  Sarkar S, Feany MB. Precision medicine on the fly: using Drosophila to decipher gene-environment interactions in Parkinson's disease, Toxicological Sciences, 2021 Aug (Cover article);

13.  Sarkar S*. Microglial Ion Channels: Key Players in Non-Cell Autonomous neurodegeneration, Neurobiology of Disease, Accepted in Press.

14.  Panicker N, Saminathan H, Jin H, Neal M, Harischandra DS, Gordon R, Kanthasamy K, Lawana V, Sarkar S, Luo J, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. J Neurosci. 2015 Jul 8;

15.  Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiol Dis. 2016 Sep;

16.  Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 Nov;

17.  Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG. Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxid Redox Signal. 2017 Nov 10;

18.  Lawana V, Singh N, Sarkar S, Charli A, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System. J Neuroimmune Pharmacol. 2017 Dec;12

19.  Sharma S, Carlson S, Puttachary S, Sarkar S, Showman L, Putra M, Kanthasamy AG, Thippeswamy T. Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy. Neurobiol Dis. 2018 Feb;

20.  Singh N, Lawana V, Luo J, Phong P, Abdalla A, Palanisamy B, Rokad D, Sarkar S, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events. Neurobiol Dis. 2018 Sep;

21.  Neal M, Luo J, Harischandra DS, Gordon R, Sarkar S, Jin H, Anantharam V, Désaubry L, Kanthasamy A, Kanthasamy A. Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia. 2018 Sep;

22.  Harischandra DS, Neal M, Rokad D, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Kanthasamy A, Anantharam V, Kanthasamy AG. Environmental neurotoxin manganese promotes cell-to-cell transmission of α-synuclein via exosomes in cell culture and animal models of Parkinson's disease. Science Signaling, 2019 March (Cover article);

23.  Panicker N, Sarkar S, Harischandra DS, Neal M, Kam T, Jin H, Saminathan H, Langley MR, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn kinase contributes to human α-synuclein induced priming and activation of the NLRP3 inflammasome in microglia, leading to exacerbated sterile inflammation and neurodegeneration in Parkinson's disease. Journal of Experimental Medicine 2019 June;

24.  Ghaisas S, Langley MR, Palanisamy BN, Dutta S, Narayanaswamy S, Plummer PJ, Sarkar S, Ay M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. MitoPark Transgenic Mouse Model Recapitulates the Gastrointestinal Dysfunction and Gut-Microbiome Changes of Parkinson's Disease. Neurotoxicology, 2019 Sept;

25.  Ghaisas S, Harischandra DS, Palanisamy BN, Proctor A,  Jin H, Sarkar S, Langley MR, Zenitsky G, Anantharam V, Kanthasamy A, Phillips GJ, Kanthasamy AG. Chronic Manganese Exposure Impairs Mitochondrial Function in the Enteric Nervous System and Induces Gastrointestinal Inflammation and Dysfunction. Environmental Health Perspectives, 2021 Aug;

26.  Hallacli E, Kayatekin C, Nazeen S, Wang HX, Sheinkopf Z, Sathyakumar S, Sarkar S, Jiang X, Dong X, Di Maio R, Wang W, Keeney M,  Felsky D, Sandoe J, Vahdatshoar A, , Xu P, Udeshi ND, Mani DR, Carr SA, Lindquist S, Jager PD, Bartel DP,  Myers CL, Greenamyre T. Feany MB, Sunyaev SR, Chung CY, Khurana V. The Parkinson’s disease protein alpha-synuclein is a modulator of RNA Processing-bodies and mRNA stability. Cell, accepted in Press.

27.  Palanisamy B, Sarkar S, Malovic E, Samidurai M, Charli A, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson’s Disease: Potential Relevance to Gut-Brain Axis Inflammation in Parkinson’s disease pathogenesis, The International Journal of Biochemistry & Cell Biology, accepted in Press.

28.  Langley MR, Rangaraju S, Dey A, Sarkar S*.  Editorial: Environmental Effects on Neuroinflammation and Neurodegeneration, Frontiers in Cellular Neuroscience Cellular Neuropathology, accepted in Press.

Book Chapter

1.  Sarkar S, Malovic E, Jin H, Kanthasamy A, Kanthasamy AG. Chapter Four - The role of manganese in neuroinflammation. In: Aschner M, Costa LG, editors. Advances in Neurotoxicology: Academic Press; 2019. p. 121-31.

2. · Beamish CR, Dey A, Sarkar S, Rand MD. Perspectives for advancing neurotoxicity studies with Drosophila. Advances in Neurotoxicology: Academic Press; in Press.

Pubmed Link:  https://www.ncbi.nlm.nih.gov/myncbi/1tWDmqj5imi5qw/bibliography/public/

Google Scholar Page: https://scholar.google.com/citations?user=N1qj3QcAAAAJ

Linkedin: https://www.linkedin.com/in/souvarishsarkar