Concerns

Because CRISPR/Cas9 is a relatively newer concept, it may have unintended consequences like genetic mutations and other health risks that could be even more dangerous to the individual than the original disease being treated.

Genetic edits made to embryos or sex cells may be passed down to future generations with unknown effects to the new individual.

People may abuse the technology and create "designer babies", where it is used to enhance certain physical/cognitive traits in humans outside of its intended purpose for curing diseases. 

As with many costly medical advancements, socioeconomic status plays a huge role in the accessibility of the CRISPR/Cas9 technology, and this gene therapy may be unavailable to those who need it most. 

Minority patients may have a limited awareness and knowledge of the CRISPR therapies due to a lack of education and resources in underdeveloped areas. 

In these earlier stages of development, this technology may be unavailable to individuals with more complex diseases, meaning they will not be able to receive the same benefits as those with more common diseases. 

Like with many other gene-editing methods, CRISPR/Cas9 technology can be challenging because all components must be delivered into cells in the right concentrations at the right times for success. 

As the technology is still being developed, it is possible that the Cas9 nuclease targets an incorrect section of the genome causing a much broader range of problems than initially present. 

Efficacy revolving the gRNA/Cas protein uptake by cells can prove to be difficult as sometimes the gene-editing activity may not occur if not taken up properly.