Research

My research focuses on developing computationally efficient Bayesian Statistical models applicable for complex datasets, especially in Genomics. At the heart of my work lies the pursuit of scalable Bayesian methods designed for the integration of multi-omic data, allowing us to delve into the intricate regulatory mechanisms governing human traits and diseases. A particular focus of my research revolves around exploring how disease mechanisms vary across individuals of different ages and sexes. This line of inquiry seeks to uncover the nuances in disease etiology and progression, ultimately guiding the design of personalized medical interventions that can significantly impact patient outcomes. 

My research interests include: 

Publications:

2024

Bayesian inference of sample-specific coexpression networks

E Saha, V Fanfani, P Mandros, MB Guebila, J Fischer, KH Shutta, ...

Genome Research, gr. 279117.124

Gene regulatory networks reveal sex difference in lung adenocarcinoma

E Saha, M Ben Guebila, V Fanfani, J Fischer, KH Shutta, P Mandros, ...

Biology of Sex Differences 15 (1), 62

Sex-biased Regulation of Extracellular Matrix Genes in COPD

CM Lopes-Ramos, KH Shutta, MH Ryu, Y Huang, E Saha, J Ziniti, ...

American Journal of Respiratory Cell and Molecular Biology

Exploring the association between daily distributional patterns of physical activity and cardiovascular mortality risk among older adults in NHANES 2003-2006

SE Cho, E Saha, M Matabuena, J Wei, R Ghosal

Annals of Epidemiology 99, 24-31

node2vec2rank: Large Scale and Stable Graph Differential Analysis via Multi-Layer Node Embeddings and Ranking

P Mandros, I Gallagher, V Fanfani, C Chen, J Fischer, A Ismail, L Hsu, ...

bioRxiv

BONOBO: Bayesian Optimized Sample-Specific Networks Obtained by Omics Data

E Saha, V Fanfani, P Mandros, M Ben-Guebila, J Fischer, KH Shutta, ...

International Conference on Research in Computational Molecular Biology, 328-331

Unveiling sex differences in lung adenocarcinoma through multi-omics integrative protein signaling networks

C Chen, E Saha, DL DeMeo, J Quackenbush, CM Lopes-Ramos

Cancer Research 84 (6_Supplement), 3490-3490

Aging-associated Alterations in the Gene Regulatory Network Landscape Associate with Risk, Prognosis and Response to Therapy in Lung Adenocarcinoma

E Saha, M Ben Guebila, V Fanfani, KH Shutta, DL DeMeo, ...

bioRxiv, 2024.07. 02.601689

Selective loss of Y chromosomes in lung adenocarcinoma modulates the tumor immune environment through cancer/testis antigens

J Fischer, KH Shutta, C Chen, V Fanfani, E Saha, P Mandros, ...

bioRxiv, 2024.09. 19.613876

Reproducible processing of TCGA regulatory networks

V Fanfani, KH Shutta, P Mandros, J Fischer, E Saha, S Micheletti, C Chen, ...

bioRxiv, 2024.11. 05.622163

2023

Gender difference in the effects of chronic diseases on daily physical activity patterns in older adults: analysis of objectively measured physical activity in NHATS 2021

E Saha, R Ghosal

Annals of Epidemiology 86, 110-118. e4

Theory of posterior concentration for generalized Bayesian additive regression trees

E Saha

arXiv preprint arXiv:2304.12505

The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks

M Ben Guebila, T Wang, CM Lopes-Ramos, V Fanfani, D Weighill, ...

Genome Biology 24 (1), 45

2021

Impact of the COVID-19 induced lockdown measures on PM2. 5 concentration in USA

R Ghosal, E Saha

Atmospheric Environment 254, 118388

Flexible Bayesian Methods for High Dimensional Data

E Saha

The University of Chicago

2020 & Earlier

On theory for BART

V Ročková, E Saha

The 22nd international conference on artificial intelligence and statistics …

Dynamic sparse factor analysis

K McAlinn, V Rocková, E Saha

arXiv preprint arXiv:1812.04187

Some high-dimensional one-sample tests based on functions of interpoint distances

E Saha, S Sarkar, AK Ghosh

Journal of Multivariate Analysis 161, 83-95

SARIMA modeling of the monthly average maximum and minimum temperatures in the eastern plateau region of India

E Saha, A Hazra, P Banik

Mausam 67 (4), 841-848