Embedded Files
Howery, et al.,
Research in Microbiology, (2018)
Positive autoregulation of flhDC operon in Proteus mirabilis
Şimşek and Kim,
The International Society for Microbial Ecology (ISME) Journal, (2018)
The emergence of metabolic heterogeneity in isogenic bacterial cells
Starvation is not an exception, but the rule for microbial systems in nature. Nutrients only occasionally come and don' t last long. Thus, how-well microbes survive starvation and utilize the nutrients once available are fundamental determinants of their populations dynamics. Here, under the microscope in the laboratory, we unveil that carbon starved bacteria can promptly take up and catabolize a newly introduced carbon source (glucose). But a small fraction of an isogenic population emerges with inactive anabolism, while the majority exhibits anabolism rapidly and grows. The cells in this subpopulation with the partial metabolism can spontaneously activate anabolism and grow at later times (hours to days). Finally, we show evidence to suggest that the partial metabolism is promoted by oxidative stress, a presumably inevitable consequence of bacterial respiration under starvation.
Coates*, Park*, et al.,
eLife, (2018)
Antibiotic-induced population fluctuations and stochastic clearance of bacteria
Howery, et al.,
Journal of Bacteriology, (2015)
Regulation of the Min cell division inhibition complex by the Rcs phosphorelay in Proteus mirabilis
* equal contribution
Bold indicates my first-authorship.
Page updated
Google Sites
Report abuse