Publications

You can find an updated list of my publications HERE

Selected publications:

1.Araldi E, Fernandez-Fuertes M, Canfran-Duque A, Tang W, Madrigal-Matute J, Basit A, Chamorro-Jorganes A, Lasuncion MA, Wu D, Fernandez-Hernando C and Suarez Y. “Lanosterol modulates innate immune responses in macrophages.” Cell Reports, 2017 Jun 27;19(13):2743-2755. 
doi: 10.1016/j.celrep.2017.05.093. 
[PhD thesis work on lanosterol function in macrophages]

2. Araldi E, Khatri R, Simon MC, Giaccia AJ, Schipani E. “Lack of HIF-2α in limb bud mesenchyme causes only a very modest and transient delay of endochondral bone development.” Nature Medicine. 2011 Jan;
17(1):25-6. [Master thesis work on hypoxia in bone development] 


3.Kobiita AA, Godbersen S, Araldi E, …., Stoffel M. “The diabetes gene JAZF1 is essential for the homeostatic control of ribosome biogenesis and function in metabolic stress.” Cell Reports 2020, 32(1),107846. https://doi.org/10.1016/j.celrep.2020.107846 
[Collaboration in the Stoffel laboratory analyzing the UK Biobank to characterize patients carrying Jazf1 polymorphisms]

4.Araldi E, Schipani E. “Hypoxia, HIFs and bone development.” Bone. 2010 Aug; 47(2):190-6. Epub 2010 May 2. 
[Highly cited review on hypoxia and bone development]

5.Aryal B, Araldi E*, Rotllan N*, … , Fernandez-Hernando C. “ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.” Nature Communications, 2016 Jul 27;7:12313. doi: 10.1038/ncomms12313 
[Collaborative project during my PhD to characterize the hematopoietic compartment of ANGPL4 knockout animals]

6. Chamorro-Jorganes A, Araldi E, Penalva LO, Sandhu D, Fernandez-Hernando C, Suarez Y. 
“MicroRNA-16 and MicroRNA-424 Regulate Cell-Autonomous Angiogenic Functions in Endothelial Cells via Targeting Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1.” Arterioscler Thrombosis Vascular Biology. 2011 Nov;31(11):2595-606. [Highly cited collaborative project during my PhD to characterize microRNA function in endothelial cells]

Other peer-reviewed publications

1. Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfran-Duque A, Diaz-Ruiz A, Araldi E, Baldan A, Camporez JP, Suarez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernandez-Hernando C. ”Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.” Cell Reports 2018 Feb 20;22(8):2133-2145. doi: 10.1016/j.celrep.2018.01.074.

2. Canfran-Duque A, Rotllan N, Zhang X, Fernandez-Fuertes M, Ramırez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernandez-Hernando C, Suarez Y. ”Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis.”EMBO Molecular Medicine, 2017 Sep;9(9):1244-1262. doi: 10.15252/emmm.201607492.

3. Montenont E, Echagarruga C, Allen N, Araldi E, Suarez Y, Berger JS. ”Platelet WDR1 suppresses platelet activity and associates with cardiovascular disease.” Blood, 2016 Sep 8. pii: blood-2016-03-703157.

4.Ulrich V, Rotllan N, Araldi E, …, Fernandez-Hernando C, Sessa WC. “Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice.” EMBO Molecular Medicine 2016 Jun 1;8(6):643-53. doi: 10.15252/emmm.201506031. 


5. Goedeke L, Rotllan N, Ramirez CM, Aranda JF, Canfran-Duque A, Araldi E, Fernandez-Hernando A, de Cabo R, Baldan A, Suarez Y, Fernandez-Hernando C. ”miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice.” Atherosclerosis, 2015 Dec;243(2):499-509. doi: 10.1016/j.atherosclerosis.2015.09.033.

6. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O’Riley R, Wilson TL, Sandusky G, Abadie J, Lyons K, Giaccia AJ, Schipani E. “Fibrosis and Hif1a-dependent tumors of the soft tissue upon loss of Vhl in mesenchymal progenitors.” The American Journal of Pathology, 2015 Nov;185(11):3090-3101. doi: 10.1016/j.ajpath.2015.07.008. Epub 2015 Sep 6.

7. Goedeke L, Rotllan N, Canfran-Duque A, Aranda JF, Ramirez CM, Araldi E, Lin CS, Anderson N, Wagschal, de Cabo R, Horton JD, Lasuncion MA, Naar AM, Suarez Y, Fernandez-Hernando C. “Identification of miR-148a as a novel regulator of cholesterol metabolism.” Nature Medicine, 2015 Oct 5. doi: 10.1038/nm.3949.

8.Chamorro-Jorganes A, Lee MY, Araldi E, …. , Suarez Y. “VEGF-Induced Expression of miR-17 92 Cluster in Endothelial Cells is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis.”, Circulation Research, 2015 Oct 15. pii: CIRCRESAHA.115.307408.


9. Rotllan N, Chamorro-Jorganes A, Araldi E, …., Suarez Y, Fernandez-Hernando C. “Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis.” FASEB Journal. 2015 Feb;29(2):597-610. doi: 10.1096/fj.14-262097 


10. Mangiavini L, Merceron C, Araldi E, …, Schipani E. “Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.” Developmental Biology. 2014 Sep 1;393(1):124-36. doi: 10.1016/j.ydbio.2014.06.013.

11.van Solingen C, Araldi E, Chamorro-Jorganes A, Fernandez-Hernando C, Suarez Y. 
“Improved repair of dermal wounds in mice lacking microRNA-155.” Journal of Cellular and Molecular Medicine. 2014 Mar 17. doi: 10.1111/jcmm.12255. 


12. Chamorro-Jorganes A, Araldi E, Rotllan N, Cirera-Salinas D, Suarez Y. “Autoregulation of glypican-1 by intronic microRNA-149 fine-tunes the angiogenic response to fibroblast growth factor in human endothelial cells.” Journal of Cell Science. 2014 Jan 24.

13. Miller AM, Gilchrist DS, Nijjar J, Araldi E, Ramirez CM, Lavery CA, Fernandez-Hernando C, McInnes IB, Kurowska-Stolarska M. “MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice.”PLoS One. 2013;8(8):e72324. doi: 10.1371/journal.pone.0072324.

14. Ramirez CM, Rotllan N, Vlassov AV, Davalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, Wanschel A, Zavadil J, Castrillo A, Kim J, Suarez Y, Fernandez-Hernando C. “Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144.” Circulation Research. 2013 Jun 7;112(12):1592-601. doi: 10.1161/CIRCRESAHA.112.300626.

15. Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I. “Notch pathway activation targets AML-initiating cell homeostasis and differentiation.” Journal of Experimental Medicine. 2013 Feb 11;210(2):301-19. doi: 10.1084/jem.20121484.

16.Rankin EB, Wu C, Khatri C, Wilson TLS, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, and Giaccia AJ. “The HIF signaling pathway in osteoblasts directly regulates erythropoiesis through the production of EPO.” Cell. 2012 Mar 30;149(1):63


17.Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Amato J. Giaccia AJ, Haigh JJ, Carmeliet G and Schipani E. “VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.” Journal of Bone Mineral Research. 2011 Dec 8. doi: 10.1002/jbmr.1487. 



18. Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, …., Aifantis I. “A novel tumor-suppressor function for the Notch pathway in myeloid leukemia.” Nature. 2011 May 12;473(7346):230-3. 


Reviews and meetings proceedings

1. Araldi E, Suarez Y. “miRNAs as regulators of endothelial cell functions in cardiometabolic diseases.” Biochim Biophys Acta. - Molecular and Cell Biology of Lipids, 2016 Jan 26. pii: S1388-1981(16)30012-9. doi: 10.1016/j.bbalip.2016.01.013. 



2. Araldi E*, Chamorro-Jorganes A*, van Solingen C*, Fernandez-Hernando C, Suarez Y. “Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.” Current Vascular Pharmacology. 2013 May 13.

3. Araldi E*, Chamorro-Jorganes A*, Suarez Y. “MicroRNAs as pharmacological targets in endothelial cell function and dysfunction.” Pharmacological Research. 2013 Sep;75:15-27.doi: 10.1016/j.phrs.2013.04.002. VII

4. Araldi E*, Krmer-Albers EM*, Nolte-’t Hoen E*, Peinado H*, Psonka-Antonczyk KM*, Rao P*, van Niel G*, Yez-M M*, Nazarenko I. “International Society for Extracellular Vesicles: first annual meeting, April 17-21, 2012: ISEV-2012” Journal of Extracellular Vesicles 2012, 1: 19995 http://dx.doi.org/10.3402/jev.v1i0.19995

5.Araldi E, Schipani E. “MicroRNA-140 and the silencing of osteoarthritis.” Genes and Development. 2010 Jun 1;24(11):1075-80.

* These authors contributed equally