In our research lab, we are dedicated to pioneering advancements in in-vivo magnetic resonance imaging (MRI), MR spectroscopy (MRS), diffusion MRI modeling, and the integration of advanced MRI techniques with artificial intelligence and deep learning technologies.

Our primary focus is innovating non-invasive imaging solutions for neurological and oncological conditions, including kidney tumors, prostate cancer, breast cancer, glioma, traumatic brain injuries (TBI), and Alzheimer's disease.

Our investigations leverage state-of-the-art techniques including radiogenomics, radiomics, and deep learning to maximize the capabilities of multiparametric MRI (mpMRI), MR spectroscopy, arterial spin labeling (ASL), relaxometry, volumetry, and advanced diffusion MR techniques across varied cancer categories.

Recent additions to our methodology include AI-based MRI super-resolution (FSRCNN, SRDenseNet), physics-informed neural networks (PINNs) for biophysically constrained glioma modeling, single-shell to multi-shell diffusion MRI synthesis, and Hybrid Multi-dimensional MRI (HM-MRI) for tissue composition mapping in prostate cancer — the first such study in the Asian population.

• MRI Super-Resolution using FSRCNN and SRDenseNet deep learning models — enabling high-resolution imaging on standard 1.5T/3T scanners

• Physics-Informed Neural Networks (PINNs) applied to glioma MRI — embedding biophysical PDEs directly into neural network training for tumor growth modeling

• Single-Shell to Multi-Shell diffusion MRI synthesis using generative AI — enabling NODDI and CHARMED modeling from standard clinical acquisitions

• Hybrid Multi-dimensional MRI (HM-MRI) in prostate cancer — first study in the Asian population for non-invasive tissue composition mapping and biopsy guidance

While cancer research forms our foundation, we are branching out, examining the symbiotic relationship between advanced MRI methods and transfer learning, especially in the context of Alzheimer's disease, breast cancer, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Osteoarthritis research. Our aspiration extends beyond understanding – we aim to diagnose and pave the way for effective management of this debilitating neurological condition.

Our vision is unwavering to pioneer early detection and minimize the invasiveness of cancer diagnostic procedures. We remain resolute in our mission to extend the frontiers of scientific understanding, mentor the next wave of research talent, and make a tangible impact in the overarching healthcare domain. 

Embracing a multidisciplinary approach, we accentuate personalized medical strategies achieved through the continuous advancement and practical application of MR techniques. Rooted in the pillars of collaboration and innovation, we are set on redefining the panorama of dementia and cancer imaging, with the ultimate goal of enhancing patient care and outcomes.