Microbiome and Cancer

Cancer and Omics Data:

We are the first paper to reveal previously unknown epigenetic regulation of TSGs in host cells through inducing DNA methyltransferase by F. nucleatum and H. hathewayi, and established the latter as CRC- promoting bacteria.

Paper: Xia, X., Wu, W. K. K., Wong, S. H., Liu, D., Kwong, T. N. Y., Nakatsu, G., Yan, P. S., Yeoh, Y. Y., Zhao, L., Wang, X., Cheng, W. Y., Chan, M. T. V., Chan, P. K. S., Sung J. J. Y., Wang M. H., Yu, J. (2020). Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer. Microbiome, 8(1), 1-13. IF: 16.837, Q1, Rank 9/136 (6.62%) in Microbiology.