Research

A: Ongoing Research

1. Multi-Biomarker Electrochemical Immunoassay Chip for Risk Assessment of Acute Kidney Injury Post-Cardiac Catheterization

Funding Agency: National Science and Technology Council, Taiwan

Grant No.: (NSTC) 114-2811-E-110-006

• Simultaneous detection of three renal biomarkers (e.g., NGAL, KIM-1, Cystatin C) using the electrochemical immunoassay chip.
  
  

• Assessment of renal function at pre-operative, immediate post-operative, and 1–2 weeks post-surgery timepoints.
  
  

• Validation of chip performance using clinical samples collected from hospital patients.

B: Past Research

1. Multiplexed Electrochemical Immunosensor for Bladder Cancer Detection

Funding Agency: Ministry of Science & Technology, Taiwan

Grant No.: MOST 107-2221-E-218-030-MY3

• Designed a 3D nanocomposite coating with oriented antibody immobilization and antifouling properties.

• Developed an electrochemical biosensor for early bladder cancer diagnosis.

2. Patch-Type Smart Sensing System for Chronic Respiratory Disease Monitoring

Funding Agency: Ministry of Science & Technology, Taiwan

Grant No.: MOST 110-2221-E-110-034-MY3

• Developed a printable nanocomposite-based conductive ink using bimetallic nanomaterials.

• Designed a wearable strain sensor for real-time respiratory monitoring.

3. Point-of-Care UACR-Based Creatinine Biosensor for Early CKD Detection

Funding Agency: Ministry of Science & Technology, Taiwan

Grant No.: MOST 111-2222-E-029-001-MY3

• Engineered core-satellite nanohybrids with zwitterion-based surface engineering for enhanced biosensing.

• Developed a novel proton exchange membrane for direct creatinine detection in untreated urine.

• Successfully translated research findings into a Taiwan ROC Patent (TWI815503B).

4. Metal-organic Frameworks with Specialized Functionalities for Biomedical Applications

Funding Agency: National Taiwan University, Ministry of Science & Technology, Taiwan

Grant No.: 11214000-1

• Developing bio-plastic and paper-based hybrid micro/nano-fluidic platforms for enhanced biomedical diagnostics.

• Investigating microfluidic-based sample enrichment techniques for circulating tumor cell (CTC) capture, integrating on-chip bio-imaging and electrochemical quantification.

5. Microstructure Manufacturing for microfluidic technologies for Affinity-based Electrochemical Detection

Funding Agency: Kaohsiung Armed Forces General Hospital

Grant No.: KAFGH_A_113062 and KAFGH_D_114083.

• Supervising research on clean room 1000-based microstructure fabrication for advanced microfluidic integration.

• Developing aptamer-functionalized hybrid biosensors for high-specificity electrochemical sensing applications.