Title : A Study on Lipoprotein Pattern in case of Diabetes Mellitus Type 2 under Treatment of Various Hypoglycemic Drugs
Advisor: Dr. Uday Kumar, Prof. & H.O.D., Clinical Biochemistry, IGIMS, Patna
Places:
Department of Biochemistry, PU, Patna
Arvind critical Diabetic care & Research centre, Patna
Indira Gandhi Institute of Medical sciences, Sheikhpura, Patna
Atherosclerosis and coronary heart disease (CHD) are the major vascular complications of diabetes and they have enormous impact on the health of those affected. The present study was carried out to determine the effect of different therapies (oral hypoglycemic drug (OHD) and insulin) on the lipid profile of diabetic patients. There are reports that in the case of diabetes mellitus the lipid profile becomes irregular and are associated with atherosclerosis and CHD.
For the present study 60 diabetic patients were selected randomly in the age group of 35-55 years, 30 of them are oral drug users and 30 use. 30 healthy persons of comparable age were selected as control. The fasting plasma sugar was estimated by O-Toluidine method, serum cholesterol and HDL-c was estimated by cholesterol oxidase-peroxidase method and serum triglyceride was estimated by glycerol-3-phosphate oxidase method. LDL-c and VLDL were estimated by using Friedelwald’s formula.
Fasting plasma glucose level was significantly higher in both the in comparison to the control group. But there was no significant difference in between insulin and OHD users. The total cholesterol, triglyceride, LDL-C, VLDL-C of diabetic patients were significantly in both the insulin and OHD users when compared to control. Whereas the HDL-C was significantly lower in diabetic patients when compared to the control.