Research

Modelling and simulation for drug delivery problems and multi-layer formulations for dissolution of drugs

• A computational model has been developed to understand drug dissolution for single and multi-layer formulations.

• The model considers diffusion, erosion, and swelling effects.

• Governing equations such as Fick's law, in the module of the transport of diluted species interface are solved by the finite element method using COMSOL multiphysics.

• Experiments are complemented with the multiphysics model that accounts for the diffusion, erosion, and swelling effects.

• Additionally, the swelling/erosion characteristics of polymers can be tailored to specific environmental and flow conditions.

Hydrodynamics of droplet generation in microfluidic devices

• A computational model was developed to understand droplet generation in a microfluidic device.

• The fluids are assumed to be Newtonian, isothermal, non-reactive, and incompressible.

• Governing equations, including N-S equations, are coupled with the conservative level set method and solved by using the finite element method using the COMSOL multiphysics.

• Results have been verified and show good agreement with the experimental and numerical studies.

• Insights from the study will help in designing microfluidic devices for dispensing droplets

Flow of a fluid past an air bubble in Microfluidic Devices:

• The simulation work aimed to explore the mechanism for eliminating air bubbles trapped in a microchannel.

• The computational domain consists of an air bubble, (a) circular and (b) elongated, placed between two parallel plates.

• The two-dimensional laminar flow is simulated using COMSOL multiphysics in combination with MATLAB.

• The results would provide insight into shear-induced particle migration in fluid flow.