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Recent studies demonstrate that cells contribute to glucose-stimulated insulin secretion (GSIS). Glucagon-like peptide-1 receptor (GLP-1R) agonists potently potentiate GSIS, making these drugs useful for diabetes treatment. However, the role of and cell paracrine interactions in the effects of GLP-1R agonists is undefined. We previously found that increased cell GLP-1R signaling activates cell GLP-1 expression. Here, we characterized the bidirectional paracrine cross-talk by which and cells communicate to mediate the effects of the GLP-1R agonist, liraglutide. We find that the effect of liraglutide to enhance GSIS is blunted by cell ablation in male mice. Furthermore, the effect of cell GLP-1R signaling to activate cell GLP-1 is mediated by a secreted protein factor that is regulated by the signaling protein, 14-3-3-zeta, in mouse and human islets. These data refine our understanding of GLP-1 pharmacology and identify 14-3-3-zeta as a potential target to enhance cell GLP-1 production.

Speed of introduction of new formulations is the key to product success. Measurement of zeta potential is one of the ways to shorten stability testing by reducing the number of candidate formulations, hence reducing the time and cost of testing as well as improving shelf life.

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Malvern Panalytical offers leading zeta potential analyzers for the measurement of zeta potential, or electrophoretic mobility. The Zetasizer Range provides a simple, fast and accurate way to measure zeta potential in either laboratory or process environments and a variety of cell types, including affordable disposable folded capillary cells.

The zeta sedimentation ratio (ZSR) is a measurement similar to the determination of the erythrocyte sedimentation rate (ESR) but possesses sevaral advantages. It is unaffected by anemia and responds in a linear manner to increase in fibrinogen and/or gamma globulin. The normal range is identical for males and females. A blood sample, contained within a vertically oriented capillary tube, is subjected to four cycles of dispersion and compaction. At the conclusion of this process, the hematocrit of the blood in the red cell-containing portion of the capillary tube is measured. This hematocrit, a measure of the closeness with which red cells will approach each other under a standardized stress, is the ZSR.

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Zeta Tau Alpha encourages our alumnae to recommend outstanding women for membership in ZTA by submitting voluntary references (Membership Information Sheets). MIS forms can be submitted electronically on the Sisters Only area of the Zeta Tau Alpha website ( ). A login from a member in good standing is required. For more information or assistance logging in, email zetataualpha@zetataualpha.org

(This information was updated on 4/12/2023.)

For the accurate determination of the zeta potential and colloidal stability, the STABINO ZETA is the first choice. It can replace the classical zeta potential measurement and is able to perform very fast titrations.

Nowadays, particle surface charge and interface potentials, such as the zeta potential and the streaming potential, are widely used to characterize the stability of suspensions, emulsions and nanoparticles. These parameters have established as a typical measure representing the electrostatic repulsion between particles.

The STABINO ZETA has a high resolution and data point density, which allows very fast, precise and reproducible zeta potential measurements. It is possible to measure the zeta potential of particles in the range of 0.3 nm to 300 m in a concentration range of up to 40 volume percent. Regarding the optimized measurement technology, the STABINO ZETA can measure up to 5 parameters simultaneously and within a few seconds: Zeta potential, streaming potential, conductivity, pH value, and temperature. In combination with our unique NANOTRAC FLEX, the particle size can also be measured as a sixth parameter simultaneously in the same sample.

To determine the quality of your samples, do you need more than just one measurement parameter? The STABINO ZETA provides you with information about the conductivity, zeta potential, streaming potential, temperature and pH of your sample with each measuring point.

Most known analytical systems are based on the zeta potential of electrophoresis, where titrations are often too inaccurate and time-consuming. For high sample throughput and thus valuable time savings, the STABINO ZETA has been optimized so that parameters required for quality assurance, for example, can be determined within seconds. For a polyelectrolyte or pH titration, the STABINO ZETA requires only 5 - 15 minutes and can record several hundred data points.

You are not only interested in the zeta potential of your sample, but also want to determine the particle size distribution?

The NANOTRAC FLEX can easily be combined with the STABINO ZETA, i.e. the NANOTRAC FLEX measuring probe can be integrated into the STABINO ZETA measuring cell. This allows the size distribution to be determined either alone or, for example, during a charge titration. Coagulation becomes "visible" in-situ based on particle size, and it is possible to identify the critical agglomeration point of a sample. This is very helpful to evaluate colloidal systems even more precisely. 006ab0faaa