Download ((TOP)) Synapse X Remake

At the synapse, an electrical signal arrives at the pre-synaptic terminal and triggers vesicles to release neurotransmitters into the synaptic cleft. The neurotransmitters activate receptors in the post-synaptic neuron and produce electrical signals.

Neurons can form excitatory connections or inhibitory ones, depending on which neurotransmitters they release across the synapse. The neurotransmitter glutamate passes along an excitatory signal, meaning that it boosts the chance that the electrical signal from the first cell will be passed along to the second. The neurotransmitters GABA and glycine, on the other hand, transmit an inhibitory message, telling the subsequent cell not to fire.

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Vesicle recycling involves three steps: First, lipid membrane must be pinched off from the neuron's membrane to form vesicles, a process called endocytosis. Then, the vesicles must be refilled with neurotransmitter. Finally, filled vesicles must be transported to the release site. Although endocytosis has been well-studied, little was known about the refilling process. Prof. Takahashi, in collaboration with a former OIST researcher and colleagues at Doshisha University, now show that for at least one major type of synapse, refilling takes longer than endocytosis.

The findings show that the refilling step can determine the rate at which vesicles are recycled and reused at the synapse. Neuroscientists have long thought that it was endocytosis that limited the speed of recycling, says Prof. Takahashi. "However, we showed that vesicle refilling rate is also an important factor."

At excitatory synapses, Prof. Takahashi's group has previously measured the rate at which glutamate is taken up into vesicles during recycling. However, this refilling rate had not been studied in inhibitory synapses. Prof. Takahashi and colleagues used glass electrodes to simultaneously take recordings from the pre-synaptic terminal and the post-synaptic terminal at an inhibitory synapse. They showed that, at inhibitory terminals, GABA is taken up into vesicles five to six times more slowly than glutamate at excitatory synapses.

More information: Manami Yamashita et al. Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression, Cell Reports (2018). DOI: 10.1016/j.celrep.2018.02.080Journal information:Cell Reports Provided byOkinawa Institute of Science and Technology Citation: Remake, refill, reuse: recycling at the synapse revealed (2018, March 26) retrieved 29 December 2023 from -03-remake-refill-reuse-recycling-synapse.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further

A neuron, when activated, propagates an electrical signal. But that signal cannot cross the synapse -- the junction between two neurons. So, communication from one neuron to the next is accomplished by the release of tiny membrane capsules containing signaling chemicals called neurotransmitters across the synapse.

Because the neurotransmitter signal goes in one direction -- from the pre-synaptic neuron to the post-synaptic one -- vesicles must be re-formed for the process to continue. "Recycling is a critical process to keep synapses functional," explains Professor Takahashi, leader of the Cellular & Molecular Synaptic Function Unit at the Okinawa Institute of Science and Technology Graduate University (OIST). In a study recently published in Cell Reports, Takahashi and his colleagues shed light on a poorly-understood part of vesicle recycling.

Remarkably, they showed that the time taken to refill the vesicles with GABA is nearly identical to the overall time taken for a synapse to recover from synaptic depression -- a neuron's inability to fire because the vesicles carrying the message across the synapse are used up. This implies that most of the recovery time is devoted to refilling the vesicles. In contrast, reforming the vesicles takes relatively less time. Vesicle refilling is time consuming because GABA is concentrated 10-100 times inside the vesicle, compared to the rest of the cell, using molecular pumps.

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