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Sonic the Hedgehog[c] is a 1991 platform game developed by Sonic Team and published by Sega for the Genesis/Mega Drive. It was released in North America on June 23 and in PAL regions and Japan the following month. Players control Sonic the Hedgehog, who can run at near supersonic speeds; Sonic sets out on a quest to defeat Dr. Robotnik, a scientist who has imprisoned animals in robots and seeks the powerful Chaos Emeralds. The gameplay involves collecting rings as a form of health, and a simple control scheme, with jumping and attacking controlled by a single button.

Development began in 1990 when Sega ordered its developers to create a game featuring a mascot for the company. The developers chose a blue hedgehog designed by Naoto Oshima after he won an internal character design contest, and named themselves Sonic Team to match their character. It uses a novel technique that allows Sonic's sprite to roll along curved scenery which was based on a concept by Oshima from 1989.[2] Sonic the Hedgehog, designed for fast gameplay, was influenced by games by Super Mario series creator Shigeru Miyamoto. The music was composed by Masato Nakamura, bassist of the J-pop band Dreams Come True.

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The team developed ideas for characters, an engine, and gameplay mechanics. Development emphasized speed, so Sega considered fast creatures such as kangaroos and squirrels and eliminated designs not associated with fast animals.[3] One idea, a rabbit able to grasp objects with prehensile ears, showed promise but was too complex for the Genesis hardware. The team narrowed its search to animals that could roll into a ball, their idea for an attacking move, and considered armadillos and hedgehogs.[12] The hedgehog character, proposed by Naoto Ohshima,[15] prevailed. Ohshima went on vacation to New York, taking sketches with him. He went to Central Park and asked locals for their opinions on them, and Sonic was the favorite. A man with a moustache, who eventually became Dr. Robotnik, was in second place.[16]

Ohshima said that "Sonic" was chosen because it represented speed.[22] Ideas proposed to flesh out the character included placing him in a rock band, giving him vampire fangs, and giving him a human girlfriend named Madonna.[23] Sega of America scrapped these ideas to keep his identity simple. Sega of America also expressed concerns that most Americans would not know what a hedgehog is.[15] According to Mark Cerny, who worked in Tokyo as an intermediary between the Japanese and American Sega offices, the American staff felt the character was "unsalvageable". They made plans to educate Sonic Team on character design with the work of Will Vinton, the creator of the California Raisins.[24] They proposed a full-scale recreation of the character, but compromised with Sonic Team to simply make design changes for western audiences.[15] The antagonist was named "Dr. Eggman" in Japan and "Dr. Robotnik" in other regions as a result of a dispute between Sega's American and Japanese divisions.[18]

Sonic the Hedgehog was developed by a team of seven: two programmers, two sound engineers, and three designers,[27] although it began with just Ohshima and Naka.[22] People came onto the team as the need for content increased.[22] After being assigned a project with the code name "Defeat Mario", Ohshima and Naka began work, but encountered problems: Ohshima's Rabbit proved hard to program. Catching items and throwing them caused the action's rhythm to break. Naka stated that the rabbit was not suitable for his game engine, and he also wanted the game to be playable with only one button. Hirokazu Yasuhara came onto the team to supervise Ohshima and Naka and develop levels. He became the lead designer due to his greater experience, and found the way to make the game playable with only one button by having Sonic do damage by jumping. The trio came up with the idea of him rolling into a ball. After the hedgehog character was chosen, many characters were redrawn, and the team agreed on the environments' visual complexity, with particular focus on the colors. After this, four people came onto the team to speed development up.[28]

Considering Sonic is known for taking on a spherical form and rolling/dashing around, it would seem the blue hedgehog would make a terrific fit for a pinball "spin" off. This is especially true given some of the level design in the main games which resembles -- and even directly takes on -- the pinball motif.

Despite feeling a touch dated on account of its '91 release - and the absence of Sonic's trademark spin dash, you have to tip your cap to the iconic debut for Sega's blue hedgehog. This platformer changed the game with its blend of fast-paced insanity and solid mechanics. You had the catchy tunes of Masato Nakamura and some colorful environments that are truly impressive for a game that's nearly 2 decades old.

Purpose: : Shh is a signaling molecule that plays critical roles in cell fate specification and cell proliferation during embryogenesis. In the vertebrate retina, the first-born retinal ganglion cells (RGCs) express Shh. Previously, we have shown that RGC-derived Shh negatively regulates RGC production behind the neurogenic wave front in the developing chicken retina. The purpose of this study is to further examine the cellular mechanisms that mediate the influence of Shh on retinogenesis. The bHLH protein Hes1 (chicken homologue Hairy2) is a transcription repressor and a downstream effector of Notch-Delta signaling pathway, which also suppresses RGC differentiation. The vertebrate homologue of the fly Atonal gene is a proneural bHLH gene required for RGC fate specification. We have investigated how Shh signaling influences these bHLH transcription factors during the peak period of RGC production in the chicken retina.

Methods: : Retroviral viral vectors were used to express Shh or Ath5 and to infect the chicken retina in vivo during early retinogenesis. Effects of perturbing Shh and Ath5 expression were analyzed by in situ hybridization, RT-PCR, immunocytochemistry and flow cytometry.

Results: : During early chicken retinal development, Shh signals stimulated Hairy2 expression and suppressed Ath5 expression. Ath5 elevation behind the neurogenic wave front resulted in a dramatic overproduction of RGCs and a mild increase of photoreceptor cells. However, misexpression of Ath5 ahead of the neurogenic wave front only caused sporadic induction of precocious neurogenesis. Furthermore, forced Ath5 expression led to decreased proliferation of retinal progenitor cells by reducing S phase reentry.

The development of basal cell carcinoma, the commonest human cancer in fair skinned populations, is clearly associated with constitutive activation of sonic hedgehog signaling. Insight into the genesis of BCC came from the identification of germline mutations of the tumor suppressor gene, PATCHED, a key regulatory component of hedgehog signaling in the nevoid basal cell carcinoma syndrome. Analysis of sporadic basal cell carcinomas and those from repair deficient xeroderma pigmentosum patients has revealed mutational inactivation of PATCHED and gain of function mutations of the proto-oncogenes, SMOOTHENED and SONIC HEDGEHOG associated with solar UV exposure. The molecular mechanisms involved in alterations of the hedgehog signaling pathway that lead to the formation of basal cell carcinomas are being unraveled and has already allowed the investigation of future therapeutic strategies for treating these skin cancers.

In 1991, Sega made everyone rethink their concept of a side-scrolling platform game. That's the year the company published Sonic the Hedgehog for its Sega Genesis console. Nintendo's Mario games typically focused on gradual progress through a level and cautious jumping, but Sonic emphasized blazing speed. While Mario was relatively slow, Sonic could run like the wind. Mario was impish and stale, Sonic was skinny and cool. Back then, Sega's blue hedgehog simultaneously revolutionized the platform genre and gave people a legitimate alternative to Nintendo's fat plumber. To celebrate that landmark moment in video game history, Sega, in a flash of delicious irony, has brought Sonic's original adventure to Nintendo's Game Boy Advance handheld. As the title suggests, Sonic the Hedgehog Genesis strives to be a pixel-for-pixel replica of the original Sega Genesis game. All of the grassy hills, speedy loops, and bouncy pinball bumpers look exactly as they did on the Genny, only now they're coming to you on the GBA. Further sweetening the pot, it also implements some welcome improvements, such as a save feature, a level select, and a mode that incorporates Sonic's spin-dash move from later games. Unfortunately, there's just one very big problem: The GBA doesn't seem to be able to keep up with Sonic's speed, and that completely breaks the game.

Sonic the Hedgehog is the first of many games starring Sega's premier hedgehog, Sonic. It's a side-scrolling platform game with a difference: speed. Sonic rushes through levels with incredible speed, allowing him to traverse loops and jumps with ease.

The Good

Sonic is one of those games that are neither hard nor too easy. the difficulty is just about right for me because it starts off easy and the difficulty progresses at just the right speed, for me at least.

The Bad

The bad dudes are perhaps a little TOO easy to crush, if it be a ground unit or an air unit all you have to do is spin attack them and they're history.Also the levels are pretty much the same. Spin attack a few dozen units and you're done!!!You could also get a little dizzy from all the spinning.

The Bottom Line

a pretty o.k game if you're a fan of sonic.

With sponsorship from SEGA, Sonic appeared on the Williams Formula 1 team in 1993. The hedgehog could be seen on the drivers' cars, and their helmets. Their rival team McLaren would often paint a squashed Sonic on their drivers' helmets after winning a race against Williams. Williams, however, would have the last laugh, when their team leader Alain Prost, secured the drivers' championship, and with the help of Damon Hill, the constructors' championship for 1993. ff782bc1db