The Annex XVII of REACH regulation contains the list of restrictions of certain hazardous substances, mixtures and articles for their marketing and use on the European market. A restriction can apply to any substance on its own, in a mixture or in an article, including those that do not require registration. The list is often known as REACH restricted substances list or simply as REACH annex XVII.

The example below is entry 61 for Dimethylfumarate (DMF) and entry 48 for toluene in REACH Annex XVII restricted substances list . The restriction conditions are listed as follows.


Download Reach Restricted Substance List (reach Annex Xvii) In Excel Table


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Some substances are literally banned by REACH annex XVII. These substances include Polychlorinated terphenyls (PCTs),asbestos fibres, pentachlorophenol and and its salts and esters, and monomethyl-tetrachlorodiphenyl methane. Many of them are persistent organic pollutants (POPs). A complete list of banned persistent organic pollutants under the Stockholm Convention can be accessed here.

If you would like to download the latest list of REACH restricted substances in excel format, please click the picture below and choose "export results to CSV" at the right bottom of the table.

REACH SVHC list is not a static list and it is updated frequently. Up to 17 Jan 2023, there are 233 substances/entries on the SVHC candidate list. Please click the picture below to download the latest REACH SVHC list in excel table. The date of inclusion is also listed.

The table has been prepared by the European Chemicals Agency (ECHA) to facilitate the searching of restricted substances in the Annex XVII of the REACH Regulation, and the table provides additional information related to the specific restriction entry.

The entry 28, 29 and 30 of REACH annex XVII restricts the use of CMR category 1A and 1B substances in products supplied to the general public (i.e, cleaning products, paints) and requires additional labeling for products intended for professional users. In this article, we have summarized how to find out if a substance is restricted, what restriction conditions are and if there are any exemptions.

Not all CMR substances are restricted by REACH. Only CMR category 1A/1B substances listed in the table 3.1 of annex VI to CLP regulation (see table below) are restricted by REACH. You can click here to download the complete table. If any substance has been assigned with hazard statement code H340, H350 or H360, it will be restricted by REACH.

The DSL is used globally by EEE manufacturers, suppliers, and IT solution providers as a common list of substances that should be declared throughout the supply chain, allowing downstream manufacturers to access product compliance to substance regulations around the world. The DSL includes declarable substances and substance groups together with reporting thresholds, reportable applications, and other information that is important for creating a material declaration.

Considering liver-related AOs (hepatotoxicity and liver cancer), evidence for TDCIPP, TCEP, TMPP, TBBPA, TPhP and TNBP relied exclusively on animal studies [9, 10, 15, 67, 68, 72]. Our search identified AOP 144 (all AOPs listed in Table 4) as a plausible mechanism for TMPP-, TBBPA-, TPhP-, TNBP- and TDCIPP-induced hepatotoxicity, and AOP 220 as a plausible mechanism for TCEP-, TBBPA-, TNBP- and TDCIPP-induced liver cancer. Considering reproductive toxicity, effects of TCEP, TMPP, TDCIPP and TPhP exposure on male tract formation and semen quality have been reported in rodent studies and a few human studies found correlations between TDCIPP and TPhP exposure and semen quality [7, 9, 41, 42, 68, 72]. We found five plausible AOPs that lead to either of the two AOs related to male reproductive toxicity. Finally, considering neurotoxicity, several fish studies report effects of most Cat I FRs on locomotor activity and a couple of human studies report statistical associations between TPhP or TCEP exposure and neurobehavior/cognition in children [8, 24, 38]. Several animal studies analyzing the neurotoxic effects of TBBPA reached contradictory conclusions, ranging from LOAELs of 0.1 mg/kg/day in mice or 0.0064 M in zebrafish to NOAELs of 1000 mg/kg/day in rats [16, 26, 32, 46, 47, 50, 77]. We also identified plausible AOPs for TPhP-, TBBPA-, TDCIPP- and TCEP-induced effects on neurobehavior/cognition. Our search, therefore, provides mechanistic supports for the major outcomes of several Cat I FRs, reinforcing the conclusion that these are plausible adverse effects of novel FRs, such as TBBPA- and TCEP-induced neurotoxicity, TDCIPP-induced liver cancer or TDCIPP- and TPhP-induced effects on male fertility. Whether these health outcomes will be observed in humans also depends on the levels of FRs to which people are exposed. e24fc04721

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