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There is something poetic, almost romantic, about a freshly-poured pint of stout from a nitro tap. The cascading effect is mesmerizing; the waterfall of tiny bubbles slowly yielding to a dark brew with a fluffy, white head thick enough to float a bottle cap.

While nitro is normally associated with a certain brewery of Irish heritage hailing from Dublin, more and more craft breweries are embracing the nitrogenated method and adding such beers to their lineups. The number of bars adding independent (non-branded) nitro taps is growing as more establishments embrace craft beer and buck the traditions of larger breweries.

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There is no official tally on the number of craft breweries that are producing nitrogenated beers, but because of the complex science (and secrecy) that goes into the canned or bottle offerings, most are sticking to draft.

One exception is Left Hand Brewing Company in Longmont, Colo., which has a Milk Stout as part of their regular lineup. Since the standard CO2 version of the stout hit shelves more than a decade ago, the brewery was working to figure out how to nitrogenize bottles.

The brewery first released a bottled nitro version of Milk Stout to the public at the 2011 Great American Beer Festival. Sullivan and others pointed out that many breweries offer the same beer on both types of taps side by side. The difference between the two is vast, with the nitro beer taking on a creamy texture and more evenly distributed flavors while the CO2 beer is more aggressive on the tongue and aroma forward.

*Lunch and snacks are provided each day. Participants with dietary restrictions should contact nitrox@wctc.edu regarding dietary needs. Please note, we cannot guarantee we will be able to meet all requests. Students may choose to pack their own lunch to ensure safety.

WCTC is committed to providing equitable access to learning opportunities. If you have a documented disability that requires accommodations, please contact the Student Accessibility Office at SAO@wctc.edu as soon as possible after registration to discuss reasonable accommodations to meet your needs. WCTC is unable to provide personal care attendants.

Kendall GT-1 Competition Motor Oil, Nitro 70, is a high-quality automotive engine oil specially formulated for use in nitromethane- and alcohol- fueled drag racing vehicles. It is not recommended for use in passenger cars or light trucks.

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The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host DNA in the cytosol. Excessive release of type I IFNs through STING-dependent mechanisms has emerged as a central driver of several interferonopathies, including systemic lupus erythematosus (SLE), Aicardi-Goutires syndrome (AGS), and stimulator of IFN genes-associated vasculopathy with onset in infancy (SAVI). The involvement of STING in these diseases points to an unmet need for the development of agents that inhibit STING signaling. Here, we report that endogenously formed nitro-fatty acids can covalently modify STING by nitro-alkylation. These nitro-alkylations inhibit STING palmitoylation, STING signaling, and subsequently, the release of type I IFN in both human and murine cells. Furthermore, treatment with nitro-fatty acids was sufficient to inhibit production of type I IFN in fibroblasts derived from SAVI patients with a gain-of-function mutation in STING. In conclusion, we have identified nitro-fatty acids as endogenously formed inhibitors of STING signaling and propose for these lipids to be considered in the treatment of STING-dependent inflammatory diseases. 152ee80cbc

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