Combining the gimlet-eye of Philip Roth with the precisive mind of Lionel Trilling, AJ Robinson writes about what goes bump in the mind, of 21st century adults. Raised in Boston, with summers on Martha's Vineyard, AJ now lives in Florida. Working, again, as an engineeer, after years out of the field due to 2009 recession and slow recovery, Robinson finds time to write. His liberal, note the small "l," sensibilities often lead to bouts of righteous indignation, well focused and true. His teen vampire adventure novel, "Vampire Vendetta," will publish in 2020. Robinson continues to write books, screenplays and teleplays and keeps hoping for that big break.
Mucopolysaccharidosis type I (MPS I) is a progressive, multi-systemic, inherited metabolic disease caused by deficiency of -L-iduronidase (IDUA). Current treatments for this disease are ineffective in treating central nervous system (CNS) disease due to the inability of lysosomal enzymes to traverse the blood-brain barrier. A noninvasive and effective approach was taken in the treatment of CNS disease by intranasal administration of an IDUA-encoding adeno-associated virus serotype 9 (AAV9) vector. Adult IDUA-deficient mice aged 3 months were instilled intranasally with AAV9-IDUA vector. Animals sacrificed 5 months post instillation exhibited IDUA enzyme activity levels that were up to 50-fold that of wild-type mice in the olfactory bulb, with wild-type levels of enzyme restored in all other parts of the brain. Intranasal treatment with AAV9-IDUA also resulted in the reduction of tissue glycosaminoglycan storage materials in the brain. There was strong IDUA immunofluorescence staining of tissue sections observed in the nasal epithelium and olfactory bulb, but there was no evidence of the presence of transduced cells in other portions of the brain. This indicates that reduction of storage materials most likely occurred as a result of enzyme diffusion from the olfactory bulb and the nasal epithelium into deeper areas of the brain. At 8 months of age, neurocognitive testing using the Barnes maze to assess spatial navigation demonstrated that treated IDUA-deficient mice were no different from normal control animals, while untreated IDUA-deficient mice exhibited significant learning and navigation deficits. This novel, noninvasive strategy for intranasal AAV9-IDUA instillation could potentially be used to treat CNS manifestations of human MPS I.
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Dr. Duff is married and has three adult children and eight grandchildren. His outside interests include spending time with family, reading mystery novels, watching movies, attending UF sporting events, and playing the acoustic guitar in a band.
Based on the 1936 science fiction novel "War with the Newts" by Czech writer, playwright and social critic Karel apek, "Newts!" is a musical podcast adaptation. While on his Watson in the Czech Republic Sam investigated apek's legacy on the country....
Bridgett Davis, filmmaker, novelist, professor, and 1982 Watson Fellow, creates "a daughter's gesture of loving defiance, an act of reclamation, an absorbing portrait of her mother in full". -Jennifer Szalai, NYT...
This rich and charming novel about a virtuous young woman's search for love amidst the fickle world of country gentry in Regency England is one of Jane Austen's most memorable works. Anne Elliot exists in a world where shallowness and hypocrisy present a challenge to her centered values and tender emotions. Anne vies for the affections of the man she loves while at the same time her willpower is threatened as she battles the conventions of a proper parochial society.
The ASPIRE project aims to improve patient safety for individuals using high-risk immunosuppressive medications. The proposed research will contribute novel information about emerging patient safety errors, rigorously evaluate a registry-based healthcare quality measurement program, and create the first toolkit to address ambulatory patient safety for immune-mediated diseases.
FrenemiesDirected byDaisy von Scherler MayerProduced byLes Morgenstein
Bob LEvyWritten byDava Savel
Wendy Weiner
Jim KriegStarringBella Thorne
Zendaya
Mary Mouser
Nick Robinson
Stefanie ScottStudio(s)Alloy Entertainment
Coin Flip ProductionsDistributorDisney Channel Original MovieReleasedJanuary 13, 2012Running time86 minutesLanguageEnglishSourceFrenemies is a 2012 television film and anthology based on the novel of the same name by Alexa Young. It features an ensemble cast of Bella Thorne, Zendaya, Stefanie Scott, Nick Robinson, and Mary Mouser. The film follows three pairs of friends that go from friends to enemies and back again. The film is directed by Daisy Mayer and written by Dava Savel, Wendy Weiner, and Jim Krieg. The Disney Channel Original Movie premiered on premiered on January 13, 2012 in the USA and January 8, 2012 in the UK.
To save on costs, many of Hallmark's Christmas and wintry movies are shot in Canada, where tax breaks and other perks allow each film's budget to stretch a little farther. For many of the network's biggest actors, spending a few blustery months in the Great White North is a novel, and cold, experience. That's not the case for Hallmark veteran Andrew Walker (the novel part, that is), as he grew up in Montreal and even booked his first few jobs in the city before moving to California.
This is an allegorical novel that defies genre. Jam lives in a world that refuses to acknowledge that monsters exist, but just because you don't acknowledge them doesn't mean they aren't there. A quick, powerful read. Recommended by Becca.
One of the best things I read in 2019 was this novel. I loved the juxtapositioning between Tru's life in Jamaica, wondering where her mother Patsy is, and Patsy's trials in New York City, keeping a light aloft for the loves never realized. Recommended by Mimosa. 2351a5e196
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