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Trained in facial plastic and reconstructive surgery, Rosenthal specializes in the treatment and reconstruction of head and neck cancer. His research interests involve the use of optical imaging techniques to better detect cancer during surgical procedures, and he has initiated multiple clinical trials in improving cancer surgery and assessing drug delivery. A mentor and frequently invited speaker, Rosenthal has authored or co-authored more than 250 peer-reviewed publications.

OHNS and the Vanderbilt Bill Wilkerson Center, which also includes the Department of Hearing and Speech Science, are recognized as international leaders in research for new treatments and cures for voice, cancer, hearing, and other diseases of the head and neck. As a result, OHNS is currently ranked No. 2 in the nation in total National Institutes of Health funding among departments of otolaryngology.

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Purpose: Positive margins dominate clinical outcomes after surgical resections in most solid cancer types, including head and neck squamous cell carcinoma. Unfortunately, surgeons remove cancer in the same manner they have for a century with complete dependence on subjective tissue changes to identify cancer in the operating room. To effect change, we hypothesize that EGFR can be targeted for safe and specific real-time localization of cancer.

Experimental design: A dose escalation study of cetuximab conjugated to IRDye800 was performed in patients (n = 12) undergoing surgical resection of squamous cell carcinoma arising in the head and neck. Safety and pharmacokinetic data were obtained out to 30 days after infusion. Multi-instrument fluorescence imaging was performed in the operating room and in surgical pathology.

Head and neck cancers become a severe threat to human's health nowadays and represent the sixth most common cancer worldwide. Surgery remains the first-line choice for head and neck cancer patients. Limited resectable tissue mass and complicated anatomy structures in the head and neck region put the surgeons in a dilemma between the extensive resection and a better quality of life for the patients. Early diagnosis and treatment of the pre-malignancies, as well as real-time in vivo detection of surgical margins during en bloc resection, could be leveraged to minimize the resection of normal tissues. With the understanding of the head and neck oncology, recent advances in optical hardware and reagents have provided unique opportunities for real-time pre-malignancies and cancer imaging in the clinic or operating room. Optical imaging in the head and neck has been reported using autofluorescence imaging, targeted fluorescence imaging, high-resolution microendoscopy, narrow band imaging and the Raman spectroscopy. In this study, we reviewed the basic theories and clinical applications of optical imaging for the diagnosis and treatment in the field of head and neck oncology with the goal of identifying limitations and facilitating future advancements in the field.

Commentators, players and fans were all divided on the red card decision with Cane collecting Jesse Kriel high with the smaller outside centre bracing for contact as the All Black's shoulder made contact with his head. The decision changed the dynamic of the match with the All Blacks playing with 14 men for the majority of the contest.

Diseases that confront otolaryngologist-head and neck surgeons cross ethnic, geographical, religious, or political boundaries and so does our membership. This was foremost on my mind as coordinator of the Scientific Program for the Foundation when I helped lead the restructuring of the Annual Meeting, which required a careful understanding of the different content demands, delivery formats, and learning styles of our membership.

Knowing we had a long hike ahead of us, we left as early as we could and started hiking the road to the trailhead. Not surprisingly, the road is not an interesting hike. Fortunately for us, when we were approaching the main road, a pick-up truck pulled up beside us. It was two of our park ranger buddies, who asked if we wanted a ride to the trailhead! K and I looked at each other, unsure if we should skip the experience of hiking the road. Thankfully, we said yes, and piled into the back of the pick-up. It was great luck, and we saved a lot of time.

The opening view from the trailhead is pretty spectacular, with a great cove next to it. As we started hiking, we left the ocean behind and starting hiking inland, through the middle of the peninsula. There were downed trees everywhere, and the existing trees struggle to get very tall due to the wind. Compared to other places we went on the island, Eastern Head is more exposed with some wide open spaces. It made for a nice change of pace.

Typically, as you would expect, a lot of us creatives find it difficult to conform to norms and so forth. I missed a lot of meetings in my first few days, and I had to figure out a way to stay ahead of that. I now have an NFC sticker on my table such that as soon as I get in, and drop my mobile on it, my calendar for the day pops up. This is typically how the day begins for me, a way to ensure I do not miss any other meetings. I use this to plan my to-do and schedule my activities around those meeting times. I do a lot of ideating, of course, and shooting happens almost every day. I came in as we were about to sign a big client, and immediately got to work on that. Initially, I had to also be the project manager for most of the work the video team was doing, but now we have a Project Manager, and because of her, I have some free time now.

Byers began taking several doses of Radithor per day, believing it gave him a "toned-up feeling", but stopped in October 1930 (after taking some 1400 doses) when that effect faded. He lost weight and had headaches, and his teeth began to fall out. In 1931, the Federal Trade Commission asked him to testify about his experience, but he was too sick to travel so the commission sent a lawyer to take his statement at his home; the lawyer reported that Byers's "whole upper jaw, excepting two front teeth and most of his lower jaw had been removed" and that "All the remaining bone tissue of his body was disintegrating, and holes were actually forming in his skull."[7]

Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

In patients with solid tumors the presence of lymph node (LN) metastases is considered an important negative prognostic factor for survival1,2. Although multiple imaging modalities are available for preoperative staging, including positron emission tomography combined with computed tomography (PET/CT) and magnetic resonance imaging (MRI), they are suboptimal in detecting occult LN (micro-) metastasis. In squamous cell carcinoma of the head and neck (HNSCC), there is up to a 30% chance of presence of occult nodal metastasis at the time of surgery, despite clinical and radiographic evidence to support the absence of tumor in the LNs of the neck (cN0)2. Consequently, patients with early stage disease and no clinical and radiographic evidence of regional LN metastasis routinely undergo an elective neck dissection3,4,5.

The current study evaluates the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

N.N and N.S.vdB designed the study, performed data acquisition, data analysis and data interpretation as well as drafting and finalizing the manuscript. N.N and N.S.vdB contributed equally to this work. B.A.M. did oversee the pathological process, harvested lymph nodes, assessed the data and critically revised the manuscript. S.vK., S.F., N.T., S.U.C., N.J.O., G.L. and C.H. supported in data collection and analysis and critically revised the manuscript. M.J.K and V.D. performed head and neck cancer surgeries, and critically revised the manuscript. A.D.C. supervised the study, signed off on inclusion of study patients, and critically revised the manuscript. E.L.R obtained funding, designed and supervised the study, performed head and neck cancer surgery, interpreted data, and drafted and assisted in finalizing the manuscript. All authors approved the final manuscript.

Dr. Chou spent five years in the San Francisco Bay Area, completing his head and neck surgery residency at Kaiser Permanente (Oakland, CA), where he trained with experts in rhinoplasty, facial feminization surgery, cleft and craniofacial surgery, and microtia reconstruction.

He then moved to New York City for a fellowship in facial plastic and reconstructive surgery at the prestigious Mount Sinai Hospital to further specialize in facial paralysis surgery, cosmetic procedures, gender-affirming facial surgery, revision rhinoplasty, and complex reconstruction. Dr. Chou takes pride in delivering the most compassionate and high-quality care for his patients, and he is excited to bring his expertise to the metro Atlanta area.

Dr. Chou is actively involved in resident and medical student education, and his academic pursuits have led him to author dozens of research publications and book chapters as well as present at numerous national surgical conferences.

As a lifelong musician, photographer, artist, and traveler, Dr. Chou is particularly passionate about the creative and humanistic aspects of facial plastic surgery. Along the way, he has coordinated Art in Medicine courses for medical students and traveled abroad to perform cleft lip surgeries and medical mission work in the Philippines.

He currently offers a full complement of facial surgery and rejuvenation procedures, including rhinoplasty, ear reconstruction (microtia), facial paralysis surgery (facial reanimation), gender-affirming facial surgery/facial feminization, skin cancer reconstruction, scar revision, face/neck lift, eyelid surgery (blepharoplasty), as well as various injectables treatments. 006ab0faaa