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The Confluence project will develop a large research resource to uncover breast cancer genetics through genome-wide association studies (GWAS). The resource will include at least 300,000 breast cancer cases and 300,000 controls of different races/ethnicities. This will be accomplished by the confluence of existing GWAS and new genome-wide genotyping data to be generated through this project.

In geography, a confluence (also: conflux) occurs where two or more watercourses join to form a single channel.[1] A confluence can occur in several configurations: at the point where a tributary joins a larger river (main stem); or where two streams meet to become the source of a river of a new name (such as the confluence of the Monongahela and Allegheny rivers at Pittsburgh, forming the Ohio); or where two separated channels of a river (forming a river island) rejoin at the downstream end.

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Confluences are studied in a variety of sciences. Hydrology studies the characteristic flow patterns of confluences and how they give rise to patterns of erosion, bars, and scour pools.[2] The water flows and their consequences are often studied with mathematical models.[3] Confluences are relevant to the distribution of living organisms (i.e., ecology) as well; "the general pattern [downstream of confluences] of increasing stream flow and decreasing slopes drives a corresponding shift in habitat characteristics."[4]

Another science relevant to the study of confluences is chemistry, because sometimes the mixing of the waters of two streams triggers a chemical reaction, particularly in a polluted stream. The United States Geological Survey gives an example: "chemical changes occur when a stream contaminated with acid mine drainage combines with a stream with near-neutral pH water; these reactions happen very rapidly and influence the subsequent transport of metals downstream of the mixing zone."[5]

Since rivers often serve as political boundaries, confluences sometimes demarcate three abutting political entities, such as nations, states, or provinces, forming a tripoint. Various examples are found in the list below.

A number of major cities, such as Chongqing, St. Louis, and Khartoum, arose at confluences; further examples appear in the list. Within a city, a confluence often forms a visually prominent point, so that confluences are sometimes chosen as the site of prominent public buildings or monuments, as in Koblenz, Lyon, and Winnipeg. Cities also often build parks at confluences, sometimes as projects of municipal improvement, as at Portland and Pittsburgh. In other cases, a confluence is an industrial site, as in Philadelphia or Mannheim. Often a confluence lies in the shared floodplain of the two rivers and nothing is built on it, for example at Manaus, described below.

One other way that confluences may be exploited by humans is as sacred places in religions. Rogers suggests that for the ancient peoples of the Iron Age in northwest Europe, watery locations were often sacred, especially sources and confluences.[8] Pre-Christian Slavic peoples chose confluences as the sites for fortified triangular temples, where they practiced human sacrifice and other sacred rites.[9] In Hinduism, the confluence of two sacred rivers often is a pilgrimage site for ritual bathing.[10] In Pittsburgh, a number of adherents to Mayanism consider their city's confluence to be sacred.[11]

Occasionally, "confluence" is used to describe the meeting of tidal or other non-riverine bodies of water, such as two canals[22] or a canal and a lake.[23] A one-mile (1.6 km) portion of the Industrial Canal in New Orleans accommodates the Gulf Intracoastal Waterway and the Mississippi River-Gulf Outlet Canal; therefore those three waterways are confluent there.

Our town was named for its location at the junction of the Casselman River and Laurel Hill Creek with the Youghiogheny River. Today, the name is more than a geographic moniker, reflecting the confluence of recreational venues and attractions that bring visitors to our friendly community from far and wide.

Reading more docs -confluence/REST/6.6.0/#content-getContentById, it says that the API will return 404 if the user is not authorized, so in my tests above using Bearer authorization the encoded username:api-token is getting interpreted as the old personal access token and failing to authenticate.

Notice that the format is set to confluence-html in the document YAML. This allows the local preview of the document to mimic the eventual appearance on Confluence. You can preview your document locally as you would any other Quarto document, by using the Render command in VS Code and RStudio, or by using quarto preview from the command line:

The South Fork Payette River is a classic pool-drop river. The Confluence recreation site is just downstream from the confluence of the Middle Fork and South Fork Payette Rivers. This site serves as a take-out point for boaters floating the Class II "Swirley Canyon" section or as a put-in for boaters tackling the Class IV "Staircase" section. The facilities include a gravel boat ramp and parking area, information kiosk, and vault toilet. This is a fee parking area - $3.00/day or $20.00 season pass for the Payette River System. Day passes are available on-site. 006ab0faaa