Publications
2024
【Original Articles】
Shima N, Yamamura A, Fujiwara M, Amano T, Matsumoto K, Sekine T, Okano H, Kondo R, Suzuki Y, Yamamura H.
Front Cardiovasc Med. 12;11:1343804 (2024).
Fukuda N, Toriuchi K, Mimoto R, Aoki H, Kakita H, Suzuki Y, Takeshita S, Tamura T, Yamamura H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.
Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4.
Neurochem Res. 49(3):800-813 (2024).
Sawai Y, Suzuki Y, Asagiri M, Hida S, Kondo R, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
Caveolin-1 forms a complex with P2X7 receptor and tunes P2X7-mediated ATP signaling in mouse bone marrow-derived macrophages.
Am J Physiol Cell Physiol. 326(1):C125-C142 (2024)
【Others】
Yamamura H.
Physiological and Pathological Significance of Chloride Channels.
Biol Pharm Bull. 47(1):1-13 (2024).
2023
【Original Articles】
Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.
Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.
J Pharmacol Sci. 53(3):153-160 (2023).
Ishida M, Yamamura A, Fujiwara M, Amano T, Ota M, Hikawa Y, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
J Pharmacol Sci. 53(2):84-88 (2023).
Kawade A, Yamamura A, Kondo R, Suzuki Y, Yamamura H.
Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling.
J Pharmacol Sci. 151(2):119-127 (2023).
Inagaki S, Suzuki Y, Kawasaki K, Kondo R, Imaizumi Y, Yamamura H.
Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca2+ signaling and proliferation in rat aortic smooth muscle cells.
Biochem Biophys Res Commun. 645:137-146 (2023).
2022
【Original Articles】
Kondo R, Deguchi A, Kawata N, Suzuki Y, Yamamura H.
Involvement of TREK1 channels in the proliferation of human hepatic stellate LX-2 cells
J Pharmacol Sci. 148(3):286-294 (2022).
Miyaki R, Yamamura A, Kawade A, Fujiwara M, Kondo R, Suzuki Y, Yamamura H.
SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells
Biochem Biophys Res Commun. 607:44-48 (2022).
Kondo R, Furukawa N, Deguchi A, Kawata N, Suzuki Y, Imaizumi Y, Yamamura H.
Downregulation of Ca2+-Activated Cl- Channel TMEM16A Mediated by Angiotensin II in Cirrhotic Portal Hypertensive Mice
Front Pharmacol. 13:831311 (2022).
Suzuki Y, Ozawa T, Kurata T, Nakajima N, Zamponi GW, Giles WR, Imaizumi Y, Yamamura H.
A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-
transcription coupling
Proc Natl Acad Sci U S A. 119(16):e2117435119 (2022).
EurekAlert "Understanding arteriosclerosis: How blood vessels restructure under pressure"
Kondo R, Kawata N, Suzuki Y, Yamamura H.
Ca2+ Signaling and Proliferation via Ca2+-Sensing Receptors in Human Hepatic Stellate LX-2 Cells
Biol Pharm Bull. 45(5):664-667 (2022).
*Featured Article
Ando S, Mizutani H, Muramatsu M, Hagihara Y, Mishima H, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H.
SKF96365 acInvolvement of small-conductance Ca2+-activated K+ (SKCa2) channels in spontaneous Ca2+ oscillations in rat
pinealocytes
Biochem Biophys Res Commun. 615:157-162 (2022).
Inagaki S, Suzuki Y, Kawasaki K, Kondo R, Imaizumi Y, Yamamura H.
Mitofusin 2 positively regulates Ca2+ signaling by tethering the sarcoplasmic reticulum and mitochondria in rat aortic smooth
muscle cells
Am J Physiol Cell Physiol. 323(2):C295-C305 (2022).
Amano T, Yamamura A, Fujiwara M, Hirai S, Kondo R, Suzuki Y, Yamamura H.
Upregulated ClC3 Channels/Transporters Elicit Swelling-Activated Cl- Currents and Induce Excessive Cell Proliferation in
Idiopathic Pulmonary Arterial Hypertension
Biol Pharm Bull. 45(11):1684-1691 (2022).
Kawata N, Kondo R, Suzuki Y, Yamamura H.
Increased TMEM16A-Mediated Ca2+-Activated Cl- Currents in Portal Vein Smooth Muscle Cells of Caveolin 1-Deficient Mice
Biol Pharm Bull. 45(11):1692-1698 (2022).
Suzuki Y, Kurata T, Koide T, Okada I, Nakajima N, Imaizumi Y, Yamamura H.
Local Ca2+ Signals within Caveolae Cause Nuclear Translocation of CaMK1α in Mouse Vascular Smooth Muscle Cells
Biol Pharm Bull. 45(9):1354-1363 (2022).
*Featured Article
【Others】
Suzuki Y, Ohya S, Giles WR.
Editorial: Regulatory mechanisms of Ca2+ activated ion channels and their impact on physiological/pathophysiological function.
Front Physiol. 13:876327 (2022).
Suzuki, Ohya, and Giles served as Guest Editors for Research Topic in Frontiers in Physiology.
2021
Yamada S, Suzuki Y, Bernotiene E, Giles WR, Imaizumi Y, Yamamura H.
Swelling-activated ClC-3 activity regulates prostaglandin E2 release in human OUMS-27 chondrocytes
Biochem Biophys Res Commun. 537:29-35 (2021).
Hashimoto D, Hirashima T, Yamamura H, Kataoka T, Fujimoto K, Hyuga T, Yoshiki A, Kimura K, Kuroki S, Tachibana M, Suzuki K, Yamamoto N, Morioka S,
Sasaki T, Yamada G.
Dynamic erectile responses of a novel penile organ model utilizing TPEM†.
Biol Reprod. 104(4):875-886 (2021).
Suzuki T, Suzuki Y, Asai K, Imaizumi Y, Yamamura H.
Hypoxia increases the proliferation of brain capillary endothelial cells via upregulation of TMEM16A Ca2+-activated Cl- channels
J Pharmacol Sci. 146(1):65-69 (2021).
Kawade A, Yamamura A, Fujiwara M, Kobayashi S, Mori S, Horii C, Hiraku A, Suzumura S, Tsukamoto K, Ohara N, Kondo R, Suzuki Y, Yamamura H.
Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats
2020
Babicheva A, Ayon RJ, Zhao T, Ek Vitorin JF, Pohl NM, Yamamura A, Yamamura H, Quinton BA, Ba M, Wu L, Ravellette KS, Rahimi S, Balistrieri F, Harrington A, Vanderpool RR, Thistlethwaite PA, Makino A, Yuan JX.
MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension.
Am J Physiol Lung Cell Mol Physiol 318(1):L10-L26 (2020).
Noda S, Suzuki Y, Yamamura H, Giles WR, Imaizumi Y.
Roles of LRRC26 as an auxiliary γ1-subunit of large-conductance Ca2+-activated K+ channels in bronchial smooth muscle cells.
Am J Physiol Lung Cell Mol Physiol 318(2):L366-L375 (2020).
Yamamura H, Suzuki Y, Asai K, Imaizumi Y, Yamamura H.
Oxidative stress facilitates cell death by inhibiting Orai1-mediated Ca2+ entry in brain capillary endothelial cells.
Biochem Biophys Res Commun. 523(1):153-158 (2020).
Noda S, Chikazawa K, Suzuki Y, Imaizumi Y, Yamamura H.
Involvement of the γ1 subunit of the large-conductance Ca2+-activated K+ channel in the proliferation of human
somatostatinoma cells.
Biochem Biophys Res Commun. 525(4):1032-1037 (2020).
Suzuki T, Yasumoto M, Suzuki Y, Asai K, Imaizumi Y, Yamamura H.
TMEM16A Ca2+-activated Cl- channel regulates the proliferation and migration of brain capillary endothelial cells.
Mol Pharmacol. 98(1):61-71 (2020).
Noda S, Suzuki Y, Yamamura H, Imaizumi Y.
Single Molecule Fluorescence Imaging Reveals the Stoichiometry of BKγ1 Subunit in Living HEK293 Cell Expression System
Biol Pharm Bull. 43(7):1118-1122 (2020).
*Highlighted paper selected by Editor-in-Chief、Featured Article
【Others】
Suzuki Y, Yamamura H, Imaizumi Y, Clark RB, Giles WR.
K+ and Ca2+ Channels Regulate Ca2+ Signaling in Chondrocytes: An Illustrated Review.
2019
Saeki T, Kimura T, Hashidume K, Murayama T, Yamamura H, Ohya S, Suzuki Y, Nakayama S, Imaizumi Y.
Conversion of Ca2+ oscillation into propagative electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+ clock model for the pacemaker activity.
Biochem Biophys Res Commun. 510(2):242-247 (2019).
Kawasaki K, Suzuki Y, Yamamura H, Imaizumi Y.
Rapid Na+ accumulation by a sustained action potential impairs mitochondria function and induces apoptosis in HEK293 cells expressing non-inactivating Na+ channels.
Biochem Biophys Res Commun. 513(1):269-274 (2019).
Kawasaki K, Suzuki Y, Yamamura H, Imaizumi Y.
Development of a Novel Cell-Based Assay System for High-Throughput Screening of Compounds Acting on Background Two-Pore Domain K+ Channels.
SLAS Discov 24(6):641-652(2019).
Minakata T, Inagaki A, Yamamura A, Yamamura H, Sekiya S, Murakami S.
Calcium-sensing receptor is functionally expressed in the cochlear perilymphatic compartment and essential for hearing.
Front Mol Neurosci 12:175 (2019) .
Saeki T, Suzuki Y, Yamamura H, Takeshima H, Imaizumi Y.
A junctophilin-caveolin interaction enables efficient coupling between ryanodine receptors and BKCa channels in the Ca2+ microdomain of vascular smooth muscle.
2018
Yamamura H, Kawasaki K, Inagaki S, Suzuki Y, Imaizumi Y.
Local Ca2+ coupling between mitochondria and sarcoplasmic reticulum following depolarization in guinea pig urinary bladder smooth muscle cells.
Am J Physiol Cell Physiol. 314(1):C88-C98 (2018).
Yamamura H, Nishimura K, Hagihara Y, Suzuki Y, Imaizumi Y.
TMEM16A and TMEM16B channel proteins generate Ca2+-activated Cl- current and regulate melatonin secretion in rat pineal glands.
J Biol Chem. 293(3):995-1006 (2018).
Hatano N, Ohya S, Imaizumi Y, Clark RB, Belke D, Giles WR.
ATP increases [Ca2+ ]i and activates a Ca2+ -dependent Cl- current in rat ventricular fibroblasts.
Exp Physiol. 103(5):666-682 (2018).
Matsuki K, Kato D, Takemoto M, Suzuki Y, Yamamura H, Ohya S, Takeshima H, Imaizumi Y.
Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle.
Am J Physiol Cell Physiol. 315(1):C1-C9 (2018).
Yamamura H, Suzuki Y, Yamamura H, Asai K, Giles W, Imaizumi Y.
Hypoxic stress upregulates Kir2.1 expression by a pathway including hypoxic-inducible factor-1α and dynamin2 in brain capillary endothelial cells.
Am J Physiol Cell Physiol. 315(2):C202-C213 (2018).
【Others】
Yamamura H, Suzuki Y, Imaizumi Y.
Physiological and Pathological Functions of Cl- Channels in Chondrocytes.