Publications
Google scholar: Divakara SSM Uppu
publications
Journal articles & reviews
DSSM Uppu, YH Min, IU Kim, S Kumar, J Park and YK Cho. Glycolipid-anchored proteins on bio-engineered extracellular vesicles for lipopolysaccharide neutralization. ACS Appl. Mater. Interfaces., 2021, doi.org/10.1021/acsami.1c05108.
DSSM Uppu, ME Turvey, ARM Sharif, K Bidet, Y He, V Ho, AD Tambe, J Lescar, EY Tan, K Fink, J Chen, and PT Hammond. Temporal release of a three-component protein subunit vaccine from polymer multilayers. J. Control. Release., 2020, 317, 130.
ME Turvey, DSSM Uppu, ARM Sharif, K Bidet, S Alonso, EE Ooi, and PT Hammond. Microneedle‐based Intradermal Delivery of Stabilized Dengue Virus. Bioeng. Transl. Med., 2019, 4, e10127.
Y He, C Hong, J Li, MT Howard, Y Li, ME Turvey, DSSM Uppu, JR Martin, K Zhang, DJ Irvine, and PT Hammond. Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination. ACS Nano 2018, 12, 10272.
Y He, J Li, ME Turvey, M Funkenbusch, C Hong, DSSM Uppu, H He, DJ Irvine, and PT Hammond. Synthetic Lift-off Polymer beneath Layer-by-layer Films for Surface Mediated Drug Delivery. ACS Macro Lett. 2017, 6, 1320.
DSSM Uppu, MM Konai, P Sarkar, S Samaddar, ICM Fensterseifer, C Farias-Junior, K Paramanandam, BR Shome, OL Franco and J Haldar. Membrane-active Macromolecules Kill Antibiotic-tolerant Bacteria and Potentiate Gram-positive Antibiotics towards Gram-negative Bacteria. PLoS One 2017, 12, e0183263.
C Ghosh, P Sarkar, S Samaddar, DSSM Uppu, and J Haldar. Lysine Based Lipidated Biphenyls as Agents with Anti-biofilm and Anti-inflammatory Properties that also Inhibit Intracellular Bacteria. Chem. Commun. 2017, 53, 8427.
DSSM Uppu, S Samaddar, C Ghosh, K Paramanandam, BR Shome, and J Haldar. Amide Side Chain Amphiphilic Polymers Disrupt Surface Established Bacterial Bio-films and Protect Mice from Chronic Acinetobacter baumannii Infection. Biomaterials 2016, 74, 131.
DSSM Uppu, MM Konai, U Baul, P Singh, T Siersma, S Samaddar, J Hoque, S Vemparala, LW Hamoen, C Narayana, and J Haldar. Isosteric Substitution in Cationic-amphiphilic Polymers Reveals an Important Role for Hydrogen Bonding in Bacterial Membrane Interactions. Chem. Sci. 2016, 7, 4613.
DSSM Uppu, S Samaddar, J Hoque, MM Konai, K Paramanandham, BR Shome, and J Haldar. Side Chain Degradable Cationic-amphiphilic Polymers with Tunable Hydrophobicity Show In-vivo Activity. Biomacromolecules. 2016, 17, 3094.
DSSM Uppu, M Bhowmik, S Samaddar, and J Haldar. Cyclization and Unsaturation rather than Isomerization of Side Chains Govern the Selective Antibacterial Activity of Cationic-amphiphilic Polymers. Chem. Commun. 2016, 52, 4644.
DSSM Uppu and J Haldar. Lipopolysaccharide Neutralization by Cationic Amphiphilic Polymers through Pseudo-aggregate Formation. Biomacromolecules 2016, 17, 862.
J Hoque, P Akkapeddi, C Ghosh, DSSM Uppu, and J Haldar. A Biodegradable Polycationic Paint That Kills Bacteria In Vitro and In Vivo. ACS Appl. Mater. Interfaces. 2016, 8, 29298.
C Ghosh, GB Manjunath, MM Konai, DSSM Uppu, K Paramanandham, BR Shome, R Ravikumar, and J Haldar. Aryl-alkyl-lysines: Membrane active small molecules active against murine model of burn infection. ACS Infect. Dis. 2016, 2, 111.
DSSM Uppu, GB Manjunath, V Yarlagadda, JE Kaivyil, R Ravikumar, and J Haldar. Membrane-active Macromolecules Re-sensitize Tetracycline Antibiotics to Gram-negative Clinical Isolates. PLoS One 2015, 10, e0119422.
C Ghosh, GB Manjunath, MM Konai, DSSM Uppu, K Paramanandham, BR Shome, and J Haldar. Aryl-alkyl-lysines: Agents that kill planktonic cells, persister cells, biofilms of MRSA and protect mice from skin-infection. PLoS One 2015, 10, e0144094.
DSSM Uppu, C Ghosh, and J Haldar. Surviving sepsis in the era of antibiotic resistance: Are there any alternative approaches to antibiotic therapy? Microb. Pathog. 2015, 80, 7.
J Hoque, P Akkapeddi, V Yadav, GB Manjunath, DSSM Uppu, MM Konai, V Yarlagadda, K Sanyal, and J Haldar. Broad spectrum antibacterial and antifungal polymeric paint materials: synthesis, structure-activity relationship and membrane-active mode of action. ACS Appl. Mater. Interfaces 2015, 7, 1804.
C Ghosh, GB Manjunath, P Akkapeddi, V Yarlagadda, J Hoque, DSSM Uppu, MM Konai, and J Haldar. Small Molecular Antibacterial Peptoid Mimics: the simpler the better! J. Med. Chem. 2014, 57, 1428.
DSSM Uppu, P Akkapeddi, GB Manjunath, V Yarlagadda, J Hoque and J Haldar. Polymers with Tunable Side-chain Amphiphilicity as Non-hemolytic Antibacterial Agents. Chem. Commun. 2013, 49, 9389.
J Hoque, P Akkapeddi, V Yarlagadda, DSSM Uppu, P Kumar, and J Haldar. Cleavable Cationic Antibacterial Amphiphiles: Synthesis, Mechanism of Action, and Cytotoxicities. Langmuir 2012, 28, 12225.
Book Chapters
DSSM Uppu, J Hoque, and J Haldar. Engineered Polymers and Organic-inorganic Hybrids as Antimicrobial Materials for Water Disinfection. Aquananotechnology: Global Prospects, CRC Press-Taylor and Francis Group, 2014. Invited.
DSSM Uppu, C Ghosh, and J Haldar. Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches. Quorum Sensing vs. Quorum Quenching: A battle with no end in sight, Springer, 2015. Invited.
Patents
DSSM Uppu, P Akkapeddi, GB Manjunath and J Haldar. Nanoparticle compositions of antibacterial compounds and other uses thereof. May 02, 2017 US9636356, WO2014006601A3, EP20152870186A2.
Oral and Poster Presentations
Materials Research Society (MRS) Spring/Fall Virtual Meeting, November 28-December 4, 2020, USA.
2nd Annual Immune Modulation & Engineering Virtual Symposium, Drexel University, November 11-13, 2020, USA.
Center for Soft and Living Matter, Institute for Basic Science (IBS), July 14, 2018, Ulsan, South Korea (Invited).
Antimicrobial Resistance-Interdisciplinary Research Group Workshop, June 2018, Singapore-MIT Alliance for Research and Technology (SMART), Singapore.
International Symposium on Functional Materials: Energy and Biomedical Applications (ISFM), April 13-15, 2018, Chandigarh, India (Invited).
EmTech Asia, The Conference on the Emerging Technologies That Matter, MIT Technology Review, 2018, Singapore.
International Conference on Cellular and Molecular Bioengineering (ICCMB4), 2017, Singapore.
TIFR Centre for Interdisciplinary Sciences, November 27, 2017, Tata Institute of Fundamental Research, Hyderabad (Invited).
Infectious Diseases-Interdisciplinary Research Group Annual Workshop, January 2017, Singapore-MIT Alliance for Research and Technology (SMART), Singapore.
International Conference on Chemical Biology (ICCB), February 6-8, 2014, Hyderabad, India.
Annual Faculty Meet, 2013, JNCASR, Bangalore India.
Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) on Antimicrobial Peptides, February 23-March, 2013, California, USA.
International Eighth JNC Materials Research Conference, 2012, Trivandrum, India.